Protein Alignment CUX2 and Cux2

DIOPT Version :10

• Sequence 1: NP_056082.2
• Gene: CUX2 / 23316
• HGNCID: 19347
• Length: 1486
• Species: Homo sapiens
• Sequence 2: XP_011246473.2
• Gene: Cux2 / 13048
• MGIID: 107321
• Length: 1595
• Species: Mus musculus
• Alignment Length: 1502
• Identity: 1234/1502 - (82%)
• Similarity: 1292/1502 - (86%)
• Gaps: 53/1502 - (3%)

Human    18 RRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVALSKRS 82
            |.|:|||:||||||||.||||..|.||.|||||||||:|||.||.||||||||||||||||||||
Mouse   114 RSLRKELSSVASELSAPQEESGLSPKHFIELRREFKKDVPEGIRAMVAPVLKSFQAEVVALSKRS 178

Human    83 QEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPELLSPKEQ 147
            :|||||||||||||||||||||.||.||:||||||.||||||||..:|:|.:|||.||..|.:||
Mouse   179 REAEAAFLSVYKQLIEAPDPVPSFEVARTLDDRLQRPSFDPSGQRLQDVHIAWKRCPEPPSAREQ 243

Human   148 REGTSPAGPTLTEGSRLPGIPGKALLTETLLQRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHS 212
            .|||.|.|.|...|:.||| |...|:|:||||:||||:|||||||.|||||||||||||||||||
Mouse   244 NEGTCPTGHTPANGNHLPG-PEDTLVTDTLLQKNEAERQKGLQEVHITLAARLGEAEEKIKVLHS 307

Human   213 ALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLA 277
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   308 ALKATQTELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLA 372

Human   278 CCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEASANQIADLERQL 342
            |||||||||:||:|.||||||||||||||||||||||||.|.|:.|||||||.||||||||||||
Mouse   373 CCSPQGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEVSANQIADLERQL 437

Human   343 TAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLLIAKEAFFPTQK 407
            .|||||||||:|||:||:||||||||||||:|||||||||||||.:|||:|.||:||:.||||||
Mouse   438 AAKSEAIEKLQEKLEAQADYEEIKTELSILRAMKLASSTCSLPQTLAKPDDPLLVAKDVFFPTQK 502

Human   408 FLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPGQPLLGPSLGPDG 472
            ||||||:||||||||||||||||.|||||..|  |.||||||||||||||||.||||||||||||
Mouse   503 FLLEKPALLASPEEDPSEDDSIKGSLGTEPPY--PPQLPPPPGPEDPLSPSPAQPLLGPSLGPDG 565

Human   473 TRTFSLSPFPSLASGERL---------MMPPAAFKGEAGGLLVFPPAFY-GAKPPTAPATPAPGP 527
            .||||||||||||.||||         ||.|||||||.|.||.|||.|| |||||:|||...|.|
Mouse   566 PRTFSLSPFPSLAPGERLAGDSLLSKHMMGPAAFKGETGNLLAFPPTFYGGAKPPSAPAASVPCP 630

Human   528 EPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEIL 592
            ||.|.||..||     |||  ||||||||||||||||||||||||||||||||||||||||||||
Mouse   631 EPTGAPEAVDG-----AGP--EEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEIL 688

Human   593 ARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQR-----------GSITPRIRTPETG 646
            |||||||||||||||||||||||||||||||||||||||||           |||||||||||||
Mouse   689 ARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGPTAATFVPLPGSITPRIRTPETG 753

Human   647 SDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQARREMQAQQQAL 711
            |||||||||||||||||||||||.|.|.|.:||.|||..:||||||||:||||||||||||||||
Mouse   754 SDDAIKSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQARREMQAQQQAL 818

Human   712 LEMEVAPRGRSVPPSPPERPSLATASQNGAPALVKQEEGSGG-----PAQAPLPVLSPAAFVQSI 771
            ||||..|||||||||||||||.||||||||...||||:|.||     ..||||.|||||||||.|
Mouse   819 LEMESGPRGRSVPPSPPERPSPATASQNGALTCVKQEDGGGGSGSSSTVQAPLAVLSPAAFVQRI 883

Human   772 IRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNGRAWPRGDEAPVPPED 836
            |||||||||||||||||||||||||||||||||||||||||  ||||||||||||||||.:.|||
Mouse   884 IRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSS--YSGQPNGRAWPRGDEATIAPED 946

Human   837 EAAAGAEDEPPRTGELKAE-GATAEAGARLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLE 900
            |||.| |||.||.|||||| ||....|.|||||||||||||||||||||||||||||||||||||
Mouse   947 EAAMG-EDEAPRVGELKAEAGAPEVGGGRLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLE 1010

Human   901 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQ 965
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1011 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQ 1075

Human   966 AVG----QQPGASQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSGK 1026
            ..|    |||.|||||||||.||||||||||||||:|||||.|||||||||||||||:||||.||
Mouse  1076 GQGQAPTQQPSASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSSLGGK 1140

Human  1027 MYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKP 1091
            .:|.|||.|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1141 PFSSSQAAGGIQEMVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKP 1205

Human  1092 WHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSP 1156
            |||||||||||||||||||:|||||||||||||||||||||||||||.|||||||||..||||||
Mouse  1206 WHKLSLKGREPFVRMQLWLSDPHNVEKLRDMKKLEKKAYLKRRYGLIGTGSDSESPAAHSECPSP 1270

Human  1157 CLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRS 1221
            |||||:|||:|.|||||||||.|||||||||||||||||||||||||||||||||||||||||||
Mouse  1271 CLQPQELSLMQAKKPRVVLAPAEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRS 1335

Human  1222 RMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQ--EGPEEN 1284
            |||||||||||||:||.||||||.:|.|||:|.:|||||||||||||||.:|.||||  |||.:.
Mouse  1336 RMRREMLVEGTQDDPDFDPSGGPNVLTPGHTHREPTPQSPDSETEDQKPPMKSLELQEPEGPLQR 1400

Human  1285 STPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPL 1349
            :.|    |:|.|:|||   ||..|.:..|||||.|:.|:||..|||||..|.||..|.::||||.
Mouse  1401 AAP----DRALVKIKQ---EEGLEVDGDSQPQDVGDPDRGQDGPKEEHTHPLGNSDLSELAPGPF 1458

Human  1350 LPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVP 1414
            |.|...|||||||..||...||::|.:||||||.||||.||||...||||..|||.|...|||.|
Mouse  1459 LSGTPNPDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAP 1523

Human  1415 SSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERAANRE 1479
            |||||||||.||||||||||.|||.|.|.|||||.|||||||||||||||||:||||:|||||||
Mouse  1524 SSSAPISPSLPGAPPAKVPSTSPTGDTAAALHPSTKVNPNLQRRHEKMANLNSIIYRLERAANRE 1588

Human  1480 EALEWEF 1486
            |.|||||
Mouse  1589 EVLEWEF 1595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUX2	NP_056082.2	PRK03918	<17..>269	CDD:235175	204/250 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..167		31/52 (60%)
		Smc	<179..>379	CDD:440809	182/199 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..481		57/65 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..549		16/31 (52%)
		CUT	553..625	CDD:460543	71/71 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..690		19/28 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..758		31/46 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..858		48/58 (83%)
		CUT	892..965	CDD:460543	72/72 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1032		56/71 (79%)
		CUT	1043..1119	CDD:460543	74/75 (99%)
		Homeodomain	1169..1225	CDD:459649	54/55 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1231..1453		143/223 (64%)
Cux2	XP_011246473.2	Smc	<274..>474	CDD:440809	182/199 (91%)
		CUT	645..721	CDD:460543	75/75 (100%)
		CUT	1002..1075	CDD:460543	72/72 (100%)
		CUT	1157..1233	CDD:460543	74/75 (99%)
		Homeodomain	1283..1339	CDD:459649	54/55 (98%)