DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ICOSLG and Icoslg

DIOPT Version :9

Sequence 1:	XP_024307828.1	Gene:	ICOSLG / 23308	HGNCID:	17087	Length:	473	Species:	Homo sapiens
Sequence 2:	XP_006256322.1	Gene:	Icoslg / 499415	RGDID:	1562791	Length:	315	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	156/307 - (50%)
Similarity:	195/307 - (63%)	Gaps:	13/307 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     6 PGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQ-TSESKTVVTYHIP- 68
            |||..|||.||..:.:.|||.|||||||||.|..|..|.|.|:|:||||| ..|:||||||::|
  Rat    10 PGLFLLLFCSLCVEAEVKEVNAMVGSDVELRCVYPRRSHFSLDDLYVYWQIVDEAKTVVTYYLPS 74

Human    69 -QNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTL 132
             ..||..:|.:.|:|||.:||..|..|||||.|.||||||.|:|.|||...|....:.|...|.|
  Rat    75 ANESSTIHVSNSYKNRAHLSPDLMKEGDFSLHLQNVTPQDTQEFKCLVFRMSTVLGKALEEVVRL 139

Human   133 HVAANFSVPVVSAPHS--PSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRG 195
            .||||||.||:|...|  |.| |.||||.|.||||.||:||||:|||:|:|:.|||:||:||..|
  Rat   140 RVAANFSTPVISTSGSSDPGQ-ERTFTCMSKNGYPEPNLYWINRTDNTLIDETLQNNTVYLNELG 203

Human   196 LYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENP--VSTGEKNAATWS 258
            ||||||.|||..||.|::.||:|||.|.||:|..|:..:..|..:  ||.|  :.........:.
  Rat   204 LYDVVSTLRIPWTPHVDVICCVENVALHQNITSISRADSFTGSMN--TERPQEIHREATKVLFYV 266

Human   259 ILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGEFAVG 305
            :.|:|.::||:.:.:.:.||.|..| ||.|..||  :.|||||...|
  Rat   267 LAALLAVVVVIFIIVLYRCRRRPCQ-SYTGPRAV--QLELTGECTCG 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICOSLG	XP_024307828.1	V-set	20..131	CDD:311561	60/113 (53%)
ICOSLG	XP_024307828.1	Ig	153..>212	CDD:325142	40/58 (69%)
Icoslg	XP_006256322.1	V-set	27..141	CDD:284989	62/113 (55%)
Icoslg	XP_006256322.1	Ig	147..234	CDD:299845	54/87 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83693585
Domainoid	1	1.000	111	1.000	Domainoid score	I40256
eggNOG	1	0.900	-	-		E1_2D335
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49412
Inparanoid	1	1.050	264	1.000	Inparanoid score	I15050
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1537230at2759
OrthoFinder	1	1.000	-	-		FOG0012612
OrthoInspector	1	1.000	-	-		otm52463
orthoMCL	1	0.900	-	-		OOG6_121964
Panther	1	1.100	-	-	LDO	PTHR24100
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	16.260