Protein Alignment ICOSLG and him-4

DIOPT Version :9

• Sequence 1: XP_024307828.1
• Gene: ICOSLG / 23308
• HGNCID: 17087
• Length: 473
• Species: Homo sapiens
• Sequence 2: NP_001024582.1
• Gene: him-4 / 181187
• WormBaseID: WBGene00001863
• Length: 5198
• Species: Caenorhabditis elegans
• Alignment Length: 268
• Identity: 57/268 - (21%)
• Similarity: 97/268 - (36%)
• Gaps: 87/268 - (32%)

Human    21 QEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT-SESKTVVTYHI-------PQNSSLENVD 77
            ::..:...:|.|:.|||        ||       || |:.||...:.|       |.|..:.:..
 Worm  1648 EDDNLEVFLGKDISLSC--------DL-------QTESDDKTTFVWSINGSESDRPDNVQIPSDG 1697

Human    78 SRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPV 142
            .|                  |.:.:..|::..|:.|.|.:.:...:..|:::|       ...||
 Worm  1698 HR------------------LYITDAKPENNGKYMCRVTNSAGKAERTLTLDV-------LEPPV 1737

Human   143 VSAPHSPSQDEL------TFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVS 201
            ...|...:..:|      ...| .:.|.|:|.|.|  |.|.:.:|::...|          :.:|
 Worm  1738 FVEPVFEANQKLIGNNPIILQC-QVTGNPKPTVIW--KIDGNDVDKSWLFD----------ESLS 1789

Human   202 VLRIART--PSVNIGCCIENV-------LLQQNLTVGSQTGNDIGERDKI--------TENPVST 249
            :|||.:.  .|..|.|..||.       ...||  :.:.|..:.|:::.|        .:.|||.
 Worm  1790 LLRIEKLTGKSAQISCTAENKAGTASRDFFIQN--IAAPTFKNEGDQETIFRESETITLDCPVSL 1852

Human   250 GEKNAATW 257
            |:.. .||
 Worm  1853 GDFQ-ITW 1859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ICOSLG	XP_024307828.1	V-set	20..131	CDD:311561	22/117 (19%)
		Ig	153..>212	CDD:325142	16/66 (24%)
him-4	NP_001024582.1	IG_like	442..515	CDD:214653
		IG	527..605	CDD:214652
		Ig	628..694	CDD:319273
		I-set	702..789	CDD:369462
		I-set	793..881	CDD:369462
		Ig	899..974	CDD:386229
		I-set	1012..1081	CDD:369462
		Ig	1109..1172	CDD:319273
		Ig	1196..1263	CDD:319273
		IG_like	1277..1358	CDD:214653
		I-set	1373..1450	CDD:369462
		Ig	1474..1544	CDD:386229
		IGc2	1563..1628	CDD:197706
		Ig	1651..1732	CDD:386229	22/113 (19%)
		Ig	1755..1818	CDD:319273	19/75 (25%)
		Ig	1839..1912	CDD:386229	6/22 (27%)
		Ig	1930..2002	CDD:386229
		IG_like	2014..2095	CDD:214653
		Ig	2094..2182	CDD:386229
		Ig	2190..2283	CDD:386229
		I-set	2296..2380	CDD:369462
		Ig	2384..2471	CDD:386229
		IGc2	2492..2556	CDD:197706
		Ig	2580..2654	CDD:386229
		Ig	2686..2753	CDD:319273
		IG_like	2768..2850	CDD:214653
		I-set	2854..2939	CDD:369462
		IG_like	2951..3031	CDD:214653
		I-set	3046..3116	CDD:369462
		I-set	3127..3213	CDD:369462
		Ig	3217..3292	CDD:386229
		I-set	3300..3386	CDD:369462
		I-set	3396..3472	CDD:369462
		I-set	3481..3569	CDD:369462
		I-set	3591..3663	CDD:369462
		Ig	3667..3762	CDD:386229
		Ig	3775..3848	CDD:386229
		Ig	3859..3947	CDD:386229
		IGc2	3968..4031	CDD:197706
		Ig_3	4045..4119	CDD:372822
		Ig_3	4136..4210	CDD:372822
		Ig	<4262..4314	CDD:386229
		Ig	4318..4406	CDD:386229
		IG_like	4418..4496	CDD:214653
		I-set	4570..4654	CDD:369462
		I-set	4752..4836	CDD:369462
		EGF_CA	4996..5027	CDD:238011
		EGF_CA	5034..5076	CDD:214542

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910