DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ICOSLG and igcm-2

DIOPT Version :9

Sequence 1:	XP_024307828.1	Gene:	ICOSLG / 23308	HGNCID:	17087	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	89/462 - (19%)
Similarity:	149/462 - (32%)	Gaps:	122/462 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    46 DLNDVYVYWQTSESKTVVTYHIPQNSSLEN-----VDSRYRNRALMSPAGMLRGD---------- 95
            |..::..||    .|......:|.:.||.|     :|.|...:.::|..|..:|.
Worm    16 DDGEMKAYW----GKAGAPITLPCSISLFNEESFSLDWRKDGQLILSAFGQEQGHVTPTLQGRLA 76

Human    96 ----FSLRLFNVTPQDEQKFHCLVL---SQSLGFQEVLSVEVTLHVAANFSVPVVSAP------H 147
                ..:.:.:||..|...:.|:|.   .|....::.||.::.::|.     ||:.:|      |
Worm    77 RDGFLGITIHSVTDGDAGVYQCIVTKFSKQPTRPEKGLSAKLVVNVP-----PVIISPSKNAIIH 136

Human   148 SPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFL--NM----RGLYDVVSVLRIA 206
            .....:|.|.|.: .|.|.|.:.|      |..:|.:....|..  |:    :|||..::|
Worm   137 KKVGADLIFECKA-EGAPSPEITW------SRNEQIISTSPVLTLSNLEEGDKGLYTCLAV---- 190

Human   207 RTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAV 271
                              |:...|.:..|:    :.|:          ||...|..|...|:...
Worm   191 ------------------NIEGNSTSSIDV----RFTK----------ATILDLIPLNKTVIEGS 223

Human   272 AIGWVCRDRCLQHSYAGAWAVSPETELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCL 336
            .:.|.|.......:.:.:|....:...|....:.|:...|       .||.:..:........|.
Worm   224 NVFWHCHANAQATAISYSWLFEKKPIKTTSLGLRSNIRSG-------DLSLQDVRKSDSGWYTCE 281

Human   337 EQLLFLETQRSPRWCAWHFLQPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPDQG 401
            .:....||..|..:.  |...||..:..|..|..|.       ..|:...|.....:|.|:....
Worm   282 AKNSAGETTSSTAYL--HVFYPPEPLSSHQPVQTVA-------SGRNTTVSCDVIANPTPTSYTW 337

Human   402 VQGGSRHRRPAPMGCPEWVQAPAPSPRGVSRAGPGTGAQPLWGVRS------GSGHRQLLSVAAT 460
            .:.|            .::...|.|...:|.|.||.|.  ::|.::      ||.....|.||..
Worm   338 SKNG------------HYLPTQASSHIIISYAKPGDGG--IYGCQADNIAGKGSIVETHLIVAEP 388

Human   461 PAALVCP 467
            |...|.|
Worm   389 PVFTVAP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICOSLG	XP_024307828.1	V-set	20..131	CDD:311561	21/106 (20%)
ICOSLG	XP_024307828.1	Ig	153..>212	CDD:325142	15/64 (23%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	16/81 (20%)
		Ig	124..200	CDD:386229	21/104 (20%)
		IG_like	214..298	CDD:214653	14/92 (15%)
		Ig_3	309..371	CDD:372822	15/82 (18%)
		Ig	389..467	CDD:386229	3/7 (43%)
		FN3	476..548	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910