DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP15 and FPR3

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	NP_013637.1	Gene:	FPR3 / 854901	SGDID:	S000004539	Length:	411	Species:	Saccharomyces cerevisiae

Alignment Length:	154	Identity:	50/154 - (32%)
Similarity:	74/154 - (48%)	Gaps:	25/154 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   155 ESEKAA-----VEFNKQV--CIAKCNSTSSLD-----------AVLSQDLIVADGPAVEVGDSLE 201
            |.||.|     |||.|.:  ...|..|....|           .::.:|..:.|||..:.|..:.
Yeast   264 EEEKKAKKVKKVEFKKDLEEGPTKPKSKKEQDKHKPKSKVLEGGIVIEDRTIGDGPQAKRGARVG 328

Human   202 VAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGS 266
            :.|.|.| :|   |:|||...: .|....|||.|:|||||:.|:.||..||:|.:|:|...|.|.
Yeast   329 MRYIGKL-KN---GKVFDKNTS-GKPFAFKLGRGEVIKGWDIGVAGMSVGGERRIIIPAPYAYGK 388

Human   267 EGVIGWTQATDSILVFEVEVRRVK 290
            :.:.|  ...:|.|.|:|::..:|
Yeast   389 QALPG--IPANSELTFDVKLVSMK 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622	8/19 (42%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		8/20 (40%)
		FKBP_C	193..286	CDD:278674	34/92 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433
		COG1340	511..781	CDD:224259
		TIMELESS_C	589..>777	CDD:252956
		SPEC	686..908	CDD:295325
		DUF4515	694..871	CDD:291649
		Ax_dynein_light	<715..780	CDD:287215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
FPR3	NP_013637.1	NPL	<118..162	CDD:407672
FPR3	NP_013637.1	FkpA	<287..410	CDD:223619	41/129 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810