DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FKBP15 and fkbp15b

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	XP_009302595.1	Gene:	fkbp15b / 571805	ZFINID:	ZDB-GENE-081105-181	Length:	1201	Species:	Danio rerio

Alignment Length:	1320	Identity:	582/1320 - (44%)
Similarity:	797/1320 - (60%)	Gaps:	220/1320 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTA 65
            ||||.|||. |||||.|||:||||||||||.: .|||.|||||||||:|..|.:   ..:|.|.|
Zfish     1 MFGADDEDG-DFLSPGGGAKLASLFGLDQATS-QGNESFQYTAPKQPRKSSGNS---GPSTQKPA 60

Human    66 PATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNF 130
            |.. ::|.:|.||||||:||.|||||||||.|||||||||.:||:||||:|||:.||.|:||..|
Zfish    61 PPA-NSPAVLFATAVHAHRYVNGQYVKQGKLGAAVLGNHTTKEYKILLYVSQQKQVTAAKIHSGF 124

Human   131 ELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLSQDLIVADGPAVE 195
            .|.|:..||.:||||||||||:|||:||||.:|:|:||:||.||..:.|:||.|||::.:|.|||
Zfish   125 ILTVQARNYCSFYDDQRQNWSLMFETEKAAADFSKEVCLAKVNSGGASDSVLIQDLVLGEGQAVE 189

Human   196 VGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPP 260
            .||||||||||||.|||..||:|||..|||||||||||:||||||||:|||.|:||||||:::||
Zfish   190 NGDSLEVAYTGWLLQNHTTGQMFDSNLNKDKLLRLKLGAGKVIKGWEEGMLNMRKGGKRLMVIPP 254

Human   261 ACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVV 325
            |.|.||:||.. ....||.|:||.|:|||||.:|.||.       |||:|||.|..::|....:.
Zfish   255 ALAYGSQGVPN-RVPPDSTLIFEAEIRRVKFVKDVGSG-------DSASPSPAPSVESLGPSELN 311

Human   326 SPPTSIPFKS--GEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQPMLPIL------PPQ 382
            .|.:|:|..|  .||.||.|||||||||   |:|||.|||||||||||||||||.:      |.|
Zfish   312 QPVSSVPQSSRPSEPPLRAKSNSLSEQL---TNPDATKAKLISRMAKMGQPMLPFITGPASSPSQ 373

Human   383 LDSNDSEIEDVNTLQGGGQPVVTPSVQ--------PSLHPAHPALPQMTSQAPQPSVTGLQAPSA 439
            .||:|||:||             |||.        ||..|.|      .|.||.|::     .:|
Zfish   374 PDSSDSELED-------------PSVSRLKERSSAPSPQPLH------ISSAPPPAL-----QTA 414

Human   440 ALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDM 504
            ||:.|      |..:.|.|...| |.:.|:            |||..:||   :|...:||:.|:
Zfish   415 ALLPV------SMAAANPQPMMP-AAIHAF------------QPVSQMYP---TQTVPYQGTSDV 457

Human   505 ASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQR 569
            .|||||||||||||||:||.|||||:|.|.:::::|||.|   |:.:...:|:|||:|||.||||
Zfish   458 TSFLMTEARQHNTEIRLAVGKVADKLDTLSSRIDDLQKQS---SVSMGLSNVSMETAMIMHNIQR 519

Human   570 IIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHA 634
            ||||||.||:|:.|||:||||||.||||||::|||||||.||:||:||:||:.::|..|||.|.|
Zfish   520 IIQENECLKKEVFEKSSRIEEQNRKISELIDQNQRYVEQRNLLMEQRNDSLKNSSEQNQARRLQA 584

Human   635 EQEK-----------AKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLT 688
            ||:|           |::||:||::||:||.|||::::.|:|.:.||.:|:.:|::......|:|
Zfish   585 EQDKHALPKELSWDQARLTEDLASSTARVSELQLELSSQQQKLSTLQSKLSAALQDNQQHCTQIT 649

Human   689 KVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQE 753
            .:.|::.||:||:|:|||::|:|||.||:||||:.:.||||.|::.||:|||:.|||||:|...|
Zfish   650 ALDAQILELKETAERAQSQYKTEKQKRKELELKLNNQEEELQDMKTEKDSLERTLSERKRKWQAE 714

Human   754 RSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKD 818
            |.:.:||::|:|::.|:|::.||..|::.|.|||.|||:|||.:|.:|:.:|:.||:..:|:|::
Zfish   715 RQRCDEELEELRRAGQQEMENLRSQLRRARTSTDHAAAQQLSQLQVDLEREWQVKCDQAVAAARE 779

Human   819 EHLQQYQEVCAQRDAYQQKLVQLQ-------------------------------EKCLALQAQI 852
            :..::..|:...||..|.||.|||                               |||..|:.::
Zfish   780 QQRRETAELSEHRDTLQSKLTQLQEKFNALKKSRESEDQRLLQQQDQSEELQAFREKCCLLEQRV 844

Human   853 TALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNGRTILGTI 917
            ..|.:|.|..:.|||...::    :...:|.:.:||::||.||||||.||:|.|:|.|..:|..:
Zfish   845 VMLKQQEETRVSELETRLTE----QQQQTDTAGEVKRVMNGVFQSLRGEFDLNETYTGSAVLRVL 905

Human   918 MNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRER-PESPM 981
            :||||.||||||.  :.|:..|..|||||..::...||.:.|    .:||.:.....|| ||...
Zfish   906 VNTIKNVTLQLLT--KAERSSSEHEEEEEDRDDEEERPDKLQ----INGQREEEEEDEREPEEIQ 964

Human   982 VPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPP 1046
            :..|:..|...|...:   .::|....||:.|: |..:|::.:...::..
Zfish   965 MKEEEEEEHTSPAEEK---KTEDTEESKGEQES-AEEKIEENASTEDMKA--------------- 1010

Human  1047 EPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSDPEEGDPLALG 1111
            :.:.|.|.::..::.|.||......|..:....|.|      ..||||..:|.::.|. |..|
Zfish  1011 DQINPNSAENTLQDQLNASAENTLLDQSTENTLVDE------FNESSTENTLLAETER-DLTA-- 1066

Human  1112 PESPGEPQPPQLKKDDVTSS----TGPHKELSSTEAGSTVAG----------------------- 1149
                         :::|||.    |||.:|:  |....:|:|
Zfish  1067 -------------REEVTSELPDVTGPAQEV--TVMDESVSGHLDEAETTETMLFGGPPKNPPPP 1116

Human  1150 -AALRP--------SHHSQRSSLSGDEEDELFKGATLKALRPKAQP------EEEDEDEVSMKGR 1199
             |||:.        :|.|.......:.|:..|:.....|..|.:.|      .:|:|:|:|:|||
Zfish  1117 PAALQDKCADTPEVTHSSSERVEEENGEEPFFQSPVPPASTPVSTPAPTEAAADEEEEELSLKGR 1181

Human  1200 PPPTPLFGDDDDDDDIDWLG 1219
            |||.||||||.|::|:||||
Zfish  1182 PPPAPLFGDDSDEEDLDWLG 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66		11/24 (46%)
		PH-like	70..168	CDD:302622	66/97 (68%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		67/96 (70%)
		FKBP_C	193..286	CDD:278674	65/92 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		24/56 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433		19/59 (32%)
		COG1340	511..781	CDD:224259	149/280 (53%)
		TIMELESS_C	589..>777	CDD:252956	98/198 (49%)
		SPEC	686..908	CDD:295325	99/252 (39%)
		DUF4515	694..871	CDD:291649	81/207 (39%)
		Ax_dynein_light	<715..780	CDD:287215	32/64 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761		11/21 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219		81/330 (25%)
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399	7/57 (12%)
fkbp15b	XP_009302595.1	FKBP_C	186..279	CDD:278674	65/93 (70%)
		DamX	287..>469	CDD:225805	97/237 (41%)
		SPEC	507..715	CDD:295325	113/207 (55%)
		Tropomyosin_1	569..713	CDD:289488	66/143 (46%)
		Ax_dynein_light	<668..742	CDD:287215	37/73 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194328676
Domainoid	1	1.000	579	1.000	Domainoid score	I1900
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	947	1.000	Inparanoid score	I2571
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59524
OrthoDB	1	1.010	-	-		D376380at33208
OrthoFinder	1	1.000	-	-		FOG0009593
OrthoInspector	1	1.000	-	-		oto43872
orthoMCL	1	0.900	-	-		OOG6_106619
Panther	1	1.100	-	-	LDO	PTHR44927
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9941
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	13	13.410