DRSC/TRiP Functional Genomics Resources

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Protein Alignment FKBP15 and shu

DIOPT Version :10

Sequence 1:NP_056073.1 Gene:FKBP15 / 23307 HGNCID:23397 Length:1219 Species:Homo sapiens
Sequence 2:NP_611837.1 Gene:shu / 45360 FlyBaseID:FBgn0003401 Length:455 Species:Drosophila melanogaster


Alignment Length:575 Identity:111/575 - (19%)
Similarity:179/575 - (31%) Gaps:203/575 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   282 FEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNS 346
            |||:..:...|||.|.|..|.|..:          |.|..|             ||......:.|
  Fly    29 FEVDNSQQNHARDLGLDSDSDSDYE----------DALDVD-------------GEELRSPWTYS 70

Human   347 LSEQLAINTSPDAVKAKLISRMAKMGQPMLPILPPQLDSNDSEIE--------------DVNTLQ 397
            ..|..|:.:..|....|.|:|...:.:..:|        |.:.:.              |.:.|:
  Fly    71 FDELRALMSEIDENIYKRITRTGHVDREAVP--------NKARVSVRYSGYWEGETAPFDSSLLR 127

Human   398 GG------GQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGN 456
            |.      ||..|                          |.||:..                   
  Fly   128 GSKFVFETGQGTV--------------------------VEGLEVA------------------- 147

Human   457 AQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASF--------LMTEAR 513
            .:|.:|        |.||..:.|.     .|....|..||..:...| |.|        |:.:|:
  Fly   148 VRSMRP--------YEQAEFIISY-----KLLFGELGCPPRIKPKAD-ALFKVEVIDYSLIGDAK 198

Human   514 QHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSML--IPSMSVTMETSMIMSNIQRIIQENER 576
                .|.....:..||...:..|..:|..|...:..|  ..|.:...|.::...|..|:..:.|.
  Fly   199 ----GIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAATAFERAVSSLNYCRMANDEEE 259

Human   577 LKQ-EILEKSNRIEEQNDKISELIERNQRYVEQSNLMM--EKRNNSLQTATENTQARVLHAEQEK 638
            .|| |:|...|:                      |||:  .|.|...:........|.|......
  Fly   260 RKQTELLTTLNQ----------------------NLMIVYNKMNKPKRACIMMKALRHLTMGNPS 302

Human   639 AKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQ 703
            .|...:...|.|                         :|.|.:|.|....:.|||....:|.|::
  Fly   303 CKALFQEGRALA-------------------------ALGEYNLARNAYLQAQAKQPANKEISDE 342

Human   704 AQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSY 768
            ..|..|           :::..||...|:.....||:.:.|:.:|..||...:|:|         
  Fly   343 IISMNK-----------RISKYEEASRDIWARAFSLKNSKSDVRKTPAQLEKEAKE--------- 387

Human   769 QEELDKLRQLLKKTRVSTDQAAAEQLSLVQAEL-QTQWEAKCEHLLASAKDEHLQ 822
            |:..||:..|:::.:.::||    |:|..:... ..|::|.|:    .||:.:|:
  Fly   388 QDFNDKMEDLIRRFKNTSDQ----QVSFSRKSYSNAQFDATCK----LAKEHNLK 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FKBP15NP_056073.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..66
PH-like 70..168 CDD:473070
Important for function in growth cone organization. /evidence=ECO:0000250 72..169
FKBP_C 193..286 CDD:459735 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..349 11/54 (20%)
Atrophin-1 307..>495 CDD:460830 31/207 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..433 8/71 (11%)
FAM184 514..710 CDD:464788 37/200 (19%)
Smc <620..>882 CDD:440809 41/204 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 739..761 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..1219
PHA03247 <951..1164 CDD:223021
shuNP_611837.1 FKBP_C 96..189 CDD:459735 24/159 (15%)
TPR repeat 218..257 CDD:276809 7/38 (18%)
TPR 230..>389 CDD:440225 43/225 (19%)
TPR repeat 262..295 CDD:276809 9/54 (17%)
TPR repeat 304..329 CDD:276809 7/49 (14%)
Blue background indicates that the domain is not in the aligned region.

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