DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FKBP15 and Fkbp15

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	XP_038966989.1	Gene:	Fkbp15 / 362528	RGDID:	1304816	Length:	1212	Species:	Rattus norvegicus

Alignment Length:	1221	Identity:	965/1221 - (79%)
Similarity:	1053/1221 - (86%)	Gaps:	11/1221 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTA 65
            |||||||||||||||||||:||||||||||:.||||||||||||||||||||.||||||:.||.|
  Rat     1 MFGAGDEDDTDFLSPSGGAKLASLFGLDQASVGHGNEFFQYTAPKQPKKGQGIAATGNQSAPKPA 65

Human    66 PATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNF 130
            |||..|.::|.||||||||..||||.||||||||||||||.||||||||||||||||||.||:||
  Rat    66 PATTGTSSVLFATAVHAYRCINGQYAKQGKFGAAVLGNHTTREYRILLYISQQQPVTVATIHLNF 130

Human   131 ELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLSQDLIVADGPAVE 195
            |||||||||||||||||||||||||||||||.||||||:|||||.|||||||.|||:.|:|||||
  Rat   131 ELMVRPNNYSTFYDDQRQNWSIMFESEKAAVAFNKQVCVAKCNSISSLDAVLCQDLVAAEGPAVE 195

Human   196 VGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPP 260
            .||||||||||||.|||||||||||||||||.||||||||||:||.|||:||||||||||:|.|.
  Rat   196 TGDSLEVAYTGWLLQNHVLGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPS 260

Human   261 ACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVV 325
            |||..|||||||||.|||||||||||||||||||||||||||||||||||||||.||:|||||||
  Rat   261 ACAAASEGVIGWTQPTDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPAADSLSADPVV 325

Human   326 SPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQPMLPILPPQLDSNDSEI 390
            :||..:|.|.||||||:||:|:||.|   ||||..|||||||||||||||||||||||||||||.
  Rat   326 TPPLPLPLKPGEPALRSKSSSVSEPL---TSPDTAKAKLISRMAKMGQPMLPILPPQLDSNDSET 387

Human   391 EDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSG 455
            ||...|:|.|..:|||||||||.|:||.||||.||||||:|:|||..|||||...||||||||||
  Rat   388 EDATLLRGAGPSLVTPSVQPSLQPSHPVLPQMASQAPQPAVSGLQTASAALMPAVSLDSHSAVSG 452

Human   456 NAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIR 520
            |||:||||||:|||.|||.|:|:|||||.||||||||||.|||||||||.|||||||||||||||
  Rat   453 NAQNFQPYAGVQAYTYPQTSSVSSQLQPARPLYPAPLSQAPHFQGSGDMMSFLMTEARQHNTEIR 517

Human   521 MAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKS 585
            |||:||||||||||||||||||||.|||||:|||||||||||||:|||||||||||||||:||||
  Rat   518 MAVNKVADKMDHLMTKVEELQKHSTGNSMLLPSMSVTMETSMIMNNIQRIIQENERLKQELLEKS 582

Human   586 NRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATA 650
            :||||||||||:|||||||||||||||||||||||||||||||||:|||||||||||||||||||
  Rat   583 SRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATA 647

Human   651 QVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNR 715
            ||||||||||||||||||||:||||:||||||||||:|::||.|.||:|.|||.|:|||||||:|
  Rat   648 QVSHLQLKMTAHQKKETELQLQLTENLKETDLLRGQVTRLQADLLELREASEQTQTKFKSEKQSR 712

Human   716 KQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK 780
            :|||||||||||||||||.||||||||||||||||||||.|||||:||||||:|||||:||||||
  Rat   713 RQLELKVTSLEEELTDLRAEKESLEKNLSERKKKSAQERCQAEEEMDEIRKSHQEELDRLRQLLK 777

Human   781 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKC 845
            |.||||||||||||||.||||::|||||||||||:|||||||||||||||||||||||..:|::|
  Rat   778 KARVSTDQAAAEQLSLAQAELKSQWEAKCEHLLATAKDEHLQQYQEVCAQRDAYQQKLSHVQDEC 842

Human   846 LALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNG 910
            |||||||.|.|:||| |::.|||:|||.....||| ||||||||||||||||||.||||||||:|
  Rat   843 LALQAQIAAFTQQNE-HMQRLEKSKSQAPAGRAAA-DPSEKVKKIMNQVFQSLRGEFELEESYDG 905

Human   911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
            ||||.|||:|||||||||||.||:|:.|.|||||:   ||:|.|||.||...|:...|.|..:.|
  Rat   906 RTILRTIMHTIKMVTLQLLNHQEEEQGECSSEEEK---EEKPLRPSLEQPGPATPRTPLALPSEE 967

Human   976 RPESPMVPSEQVVEEAVPLPPQALTTSQDG-HRRKGD-SEAEALSEIKDGSLPPELSCIPSHRVL 1038
            ..|:|.|.||||..|..|||.|||...::| ..|||: ||.|..|||||.|||||.:..|:||||
  Rat   968 PQEAPKVLSEQVEGETTPLPLQALPMPENGAQTRKGEPSEPEVSSEIKDSSLPPEPAGFPAHRVL 1032

Human  1039 GPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSDPE 1103
            ||||||||:|.|||::|||.||::||.....:|::...:..|||||.||.||.:..|||||.|||
  Rat  1033 GPPTSIPPKPPGPVTIDSESEETVAAGQRTLQPNSLLEEEHVREVATDGLLQGNPRRLSLTPDPE 1097

Human  1104 EGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEE 1168
            :.:|.||.|||..|||||.||:....||:|| .|:..||..:...||:.|.|..||..|:|||||
  Rat  1098 KKEPPALDPESQEEPQPPVLKQAKDISSSGP-CEVMDTERAAADTGASPRHSQDSQHCSVSGDEE 1161

Human  1169 DELFKGATLKALRPKAQPEEEDEDEVSMKGRPPPTPLFGDDDDDDDIDWLG 1219
            ||||||||||..||.||||||||||||||||||||||||||||||||.|||
  Rat  1162 DELFKGATLKVPRPTAQPEEEDEDEVSMKGRPPPTPLFGDDDDDDDIGWLG 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66		20/24 (83%)
		PH-like	70..168	CDD:302622	85/97 (88%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		85/96 (89%)
		FKBP_C	193..286	CDD:278674	80/92 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		43/54 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433		37/51 (73%)
		COG1340	511..781	CDD:224259	243/269 (90%)
		TIMELESS_C	589..>777	CDD:252956	167/187 (89%)
		SPEC	686..908	CDD:295325	180/221 (81%)
		DUF4515	694..871	CDD:291649	146/176 (83%)
		Ax_dynein_light	<715..780	CDD:287215	58/64 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761		20/21 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219		171/289 (59%)
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399	35/57 (61%)
Fkbp15	XP_038966989.1	FKBP_C	193..286	CDD:395196	80/92 (87%)
		PRK10263	<397..>494	CDD:236669	74/96 (77%)
		Smc	<560..889	CDD:224117	283/330 (86%)
		PHA03247	<944..1115	CDD:223021	92/170 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83681001
Domainoid	1	1.000	1349	1.000	Domainoid score	I752
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H28743
Inparanoid	1	1.050	1732	1.000	Inparanoid score	I2043
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG59524
OrthoDB	1	1.010	-	-		D10375at314146
OrthoFinder	1	1.000	-	-		FOG0009593
OrthoInspector	1	1.000	-	-		oto142738
orthoMCL	1	0.900	-	-		OOG6_106619
Panther	1	1.100	-	-	LDO	PTHR44927
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9941
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410