DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FKBP15 and Fkbp15

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	XP_006538097.1	Gene:	Fkbp15 / 338355	MGIID:	2444782	Length:	1255	Species:	Mus musculus

Alignment Length:	1215	Identity:	955/1215 - (78%)
Similarity:	1044/1215 - (85%)	Gaps:	18/1215 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTA 65
            |||||||||||||||||||:||||||||||..||||||||||||||||||||||| |||..||.|
Mouse     1 MFGAGDEDDTDFLSPSGGAKLASLFGLDQATMGHGNEFFQYTAPKQPKKGQGTAA-GNQTAPKPA 64

Human    66 PATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNF 130
            |||..|.::|.|||||||||.||||.||||||||||||||:||||||||||||||||||.||:||
Mouse    65 PATTGTSSVLFATAVHAYRYINGQYAKQGKFGAAVLGNHTSREYRILLYISQQQPVTVATIHLNF 129

Human   131 ELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLSQDLIVADGPAVE 195
            |||||||||||||||||||||||||||||||.||||||:|||||.|||||||.|||:.|:|||||
Mouse   130 ELMVRPNNYSTFYDDQRQNWSIMFESEKAAVSFNKQVCVAKCNSISSLDAVLCQDLVAAEGPAVE 194

Human   196 VGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPP 260
            .||||||||||||.|||||||||||||||||.||||||||||:||.|||:||||||||||:|.|.
Mouse   195 TGDSLEVAYTGWLLQNHVLGQVFDSTANKDKPLRLKLGSGKVVKGLEDGLLGMKKGGKRLIITPS 259

Human   261 ACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVV 325
            |||.||||||||||.|||||||||||||||||||||||||||||||||||||||.:|:|||||||
Mouse   260 ACAAGSEGVIGWTQPTDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPASDSLSADPVV 324

Human   326 SPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQPMLPILPPQLDSNDSEI 390
            : |..:|.|.|||.||:|||||||||.:|::||.||||||||||||||||||||||||||||||.
Mouse   325 T-PLPLPLKPGEPGLRSKSNSLSEQLTVNSNPDTVKAKLISRMAKMGQPMLPILPPQLDSNDSET 388

Human   391 EDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSG 455
            ||...|:|.||.:||||:||||.||||.||||.|||||||.:|||.|||||||..||||||||||
Mouse   389 EDATVLRGAGQSLVTPSIQPSLQPAHPVLPQMASQAPQPSGSGLQTPSAALMQAVSLDSHSAVSG 453

Human   456 NAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIR 520
            |||:||||||:|||||||..:||||||||||||||||||.|||||||||.|||||||||||||||
Mouse   454 NAQNFQPYAGVQAYAYPQTPSVTSQLQPVRPLYPAPLSQAPHFQGSGDMMSFLMTEARQHNTEIR 518

Human   521 MAVSKVADKMDHLMTKVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKS 585
            |||:||||||||||||||||||||:|||||:|||||||||||||||||||||||||||||:||||
Mouse   519 MAVNKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMETSMIMSNIQRIIQENERLKQELLEKS 583

Human   586 NRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATA 650
            :||||||||||:|||||||||||||||||||||||||||||||||:|||||||||||||||||||
Mouse   584 SRIEEQNDKISDLIERNQRYVEQSNLMMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATA 648

Human   651 QVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNR 715
            ||||||||||||||||||||:|||::|||||||||.:|::||.||||:|.|||.|:|||||||:|
Mouse   649 QVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSR 713

Human   716 KQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK 780
            :|||||||||||||||||.||.|||||||||||||||||.|||.|:||||||:|||||:||||||
Mouse   714 RQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLK 778

Human   781 KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKC 845
            |.||||||||||||:|.|||||:|||||||.|||||:|||||||:||||||||:||||..||::|
Mouse   779 KARVSTDQAAAEQLTLAQAELQSQWEAKCEQLLASARDEHLQQYREVCAQRDAHQQKLALLQDEC 843

Human   846 LALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNG 910
            |||||||.|.|:|.| |::.|||.|||.....||| ||||||||||||||||||.||||||||:|
Mouse   844 LALQAQIAAFTEQKE-HMQRLEKTKSQAPAGRAAA-DPSEKVKKIMNQVFQSLRGEFELEESYDG 906

Human   911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRE 975
            .|||.|||:|||||||||||.||:|:|    |||||:.|::|.|||.||...|:.|.|.||.:.|
Mouse   907 GTILRTIMHTIKMVTLQLLNHQEEEEE----EEEEEEEEKKPLRPSLEQPGPATPGMPPAPPSGE 967

Human   976 RPESPMVPSEQVVEEAVPLPPQALTTSQDG-HRRKGD-SEAEALSEIKDGSLPPELSCIPSHRVL 1038
            ..|:|.|..||||.|..|||.|||.|.::| ..|||: :|||..|||||.||||:.:.||:||||
Mouse   968 TQEAPEVLPEQVVGETTPLPLQALPTPENGAQTRKGEPAEAEVPSEIKDSSLPPQPAGIPAHRVL 1032

Human  1039 GPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSDPE 1103
            ||||||||:|.|||:||||.||.|||.....:|:...|:..|||||.||.||.:|.|||||.|||
Mouse  1033 GPPTSIPPKPPGPVTMDSESEEMLAADQRTVQPNGLLGEEHVREVATDGLLQGNSRRLSLTPDPE 1097

Human  1104 EGDPLALGPESP-GEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDE 1167
            :|:|.||.|||. ||.|||:.|:.:..||:||.:.|..||..|..||.:||.:..||..||||||
Mouse  1098 KGEPPALDPESQGGEAQPPECKQAEDVSSSGPRETLLDTELASAAAGTSLRHNQDSQHCSLSGDE 1162

Human  1168 EDELFKGATLKALRPKAQPEEEDEDEVSMKGRP-----PPTPLFG 1207
            |||||||||||..||.|||||||||||..  ||     |.|..:|
Mouse  1163 EDELFKGATLKVPRPTAQPEEEDEDEVVR--RPQALLSPHTTTWG 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66		20/24 (83%)
		PH-like	70..168	CDD:302622	86/97 (89%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		86/96 (90%)
		FKBP_C	193..286	CDD:278674	81/92 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		42/54 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433		38/51 (75%)
		COG1340	511..781	CDD:224259	241/269 (90%)
		TIMELESS_C	589..>777	CDD:252956	164/187 (88%)
		SPEC	686..908	CDD:295325	175/221 (79%)
		DUF4515	694..871	CDD:291649	142/176 (81%)
		Ax_dynein_light	<715..780	CDD:287215	56/64 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761		19/21 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219		162/285 (57%)
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399	38/57 (67%)
Fkbp15	XP_006538097.1	FKBP_C	192..285	CDD:365980	81/92 (88%)
		PRK10263	<378..>489	CDD:236669	88/110 (80%)
		Smc	<561..890	CDD:224117	278/330 (84%)
		PHA03247	<944..1129	CDD:223021	105/184 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955465
Domainoid	1	1.000	1364	1.000	Domainoid score	I806
eggNOG	1	0.900	-	-		E1_COG0545
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H28743
Inparanoid	1	1.050	1870	1.000	Inparanoid score	I1872
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG59524
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009593
OrthoInspector	1	1.000	-	-		oto126677
orthoMCL	1	0.900	-	-		OOG6_106619
Panther	1	1.100	-	-	LDO	PTHR44927
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10049
SonicParanoid	1	1.000	-	-		X9941
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.290