DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP15 and SPAC27F1.06c

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	NP_594535.1	Gene:	SPAC27F1.06c / 2541479	PomBaseID:	SPAC27F1.06c	Length:	362	Species:	Schizosaccharomyces pombe

Alignment Length:	301	Identity:	69/301 - (22%)
Similarity:	106/301 - (35%)	Gaps:	91/301 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFGA----GDEDDTDFLS--------PSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGT 53
            ::||    .||::.|.:|        ...|||:..|...::.|.....|..:...||
pombe   140 LYGADEFSSDEEEMDDISVTSSEEEEEENGARIEELNSDEEDAEQAEEEILEKPVPK-------- 196

Human    54 AATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQ 118
                ::...|.:...:........|||......||   |:.|...|..|..|.::
pombe   197 ----DEVAEKHSKDKLKKEEKEKKTAVDVSDSVNG---KKRKTEPAGEGEQTEKK---------- 244

Human   119 QPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLS 183
                                                  .|:...:.|||....         |..
pombe   245 --------------------------------------SKSTKTYPKQVLEGN---------VTV 262

Human   184 QDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGM 248
            ||.:..||||.:....:.:.|.|.|..    |:|||.... .|.....||..:|||||:.|::||
pombe   263 QDKVKGDGPAAKRKKRVSMRYIGRLTN----GKVFDKNIT-GKPFTFNLGLEEVIKGWDVGIVGM 322

Human   249 KKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRV 289
            :.||:|.:.:|.|.|.||:.:.|....:|  |||:|::..|
pombe   323 QVGGERTIHIPAAMAYGSKRLPGIPANSD--LVFDVKLLAV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66		3/24 (13%)
		PH-like	70..168	CDD:302622	13/97 (13%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		14/96 (15%)
		FKBP_C	193..286	CDD:278674	33/92 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433
		COG1340	511..781	CDD:224259
		TIMELESS_C	589..>777	CDD:252956
		SPEC	686..908	CDD:295325
		DUF4515	694..871	CDD:291649
		Ax_dynein_light	<715..780	CDD:287215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
SPAC27F1.06c	NP_594535.1	FkpA	152..362	CDD:223619	65/289 (22%)
SPAC27F1.06c	NP_594535.1	FKBP_C	272..359	CDD:278674	33/93 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810