DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP15 and fkbp39

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	NP_596694.1	Gene:	fkbp39 / 2539812	PomBaseID:	SPBC1347.02	Length:	361	Species:	Schizosaccharomyces pombe

Alignment Length:	126	Identity:	44/126 - (34%)
Similarity:	68/126 - (53%)	Gaps:	13/126 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   170 AKCNSTSS------LDAVLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLL 228
            |..|:.||      ...|:..|:....|.:...|..:|:.|.|.| :|   |:|||.. .|.|..
pombe   242 ASSNAPSSPKTRTLKGGVVVTDVKTGSGASATNGKKVEMRYIGKL-EN---GKVFDKN-TKGKPF 301

Human   229 RLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRV 289
            ...||.|:||:||:.|:.||::||:|.:.:|...|.|::.:.|..:  :|.|||||::.||
pombe   302 AFILGRGEVIRGWDVGVAGMQEGGERKITIPAPMAYGNQSIPGIPK--NSTLVFEVKLVRV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169
		FKBP_C	193..286	CDD:278674	35/92 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433
		COG1340	511..781	CDD:224259
		TIMELESS_C	589..>777	CDD:252956
		SPEC	686..908	CDD:295325
		DUF4515	694..871	CDD:291649
		Ax_dynein_light	<715..780	CDD:287215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
fkbp39	NP_596694.1	FkpA	<201..361	CDD:223619	44/126 (35%)
fkbp39	NP_596694.1	FKBP_C	272..358	CDD:278674	35/92 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810