DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FKBP15 and fkb-6

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	NP_508026.1	Gene:	fkb-6 / 180371	WormBaseID:	WBGene00001431	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	634	Identity:	118/634 - (18%)
Similarity:	196/634 - (30%)	Gaps:	248/634 - (39%)

- Green bases have known domain annotations that are detailed below.

Human   174 STSSLDAVLSQD-----LIVADGPAV---EVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRL 230
            |...:|....:|     ||..:|..|   ..|.:::|.|.|.| :|   |..|||:.::......
Worm     2 SGEKIDITPKKDGGVLKLIKKEGQGVVKPTTGTTVKVHYVGTL-EN---GTKFDSSRDRGDQFSF 62

Human   231 KLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDS 295
            .||.|.|||||:.|:..|.||                                 ||.......|.
Worm    63 NLGRGNVIKGWDLGVATMTKG---------------------------------EVAEFTIRSDY 94

Human   296 GSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV 360
            |..       |:.:|..|||...|..:.                      .|.|..|.:.|||
Worm    95 GYG-------DAGSPPKIPGGATLIFEV----------------------ELFEWSAEDISPD-- 128

Human   361 KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQ 425
                                     .|..|.....::|                :..:.|..||:
Worm   129 -------------------------RDGTILRTIIVEG----------------SKNSFPNDTSK 152

Human   426 APQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPA 490
            .                             .|.....|.|.:.|
Worm   153 V-----------------------------LAHCVGTYQGTEFY--------------------- 167

Human   491 PLSQPPHFQ-GSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVE-ELQKHSAGNS----M 549
              ::..:|. |.|.      .|......|..:...::.:|     :|:| ...|::.|||    .
Worm   168 --NREVNFHIGEGS------EEGLPEGVERALRRFQLGEK-----SKIEIRGHKYTYGNSPPAGS 219

Human   550 LIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMME 614
            .|| ::.|:|.::.:...:::....|...:|.|:.:.:.:          :|...|:::.||.:
Worm   220 NIP-VNATLEFTIFLKEFEKVPATWEMTAEEKLDAAKQAK----------DRGTMYLQKGNLKL- 272

Human   615 KRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKE 679
             ..|..:.|.|     ||  |.||:...|::|                 ::||
Worm   273 -AYNKYKRAEE-----VL--EYEKSTDPEKMA-----------------ERET------------ 300

Human   680 TDLLRG---QLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKESLEK 741
              :|.|   .|:.|.:|.:|..|..:......:::..|.|.|..|.|:| ..:.::|...:..||
Worm   301 --ILNGAYLNLSLVCSKQNEQLECIKWCDKVLETKPGNVKALYRKATAL-LTMNEVRDAMKLFEK 362

Human   742 --NLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQ 788
              .:....|.:||:.......|.|     |.|.||.|......::||::
Worm   363 IVEVEPENKAAAQQIIVCRNTIRE-----QNERDKKRFKNLFAKISTEE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169
		FKBP_C	193..286	CDD:278674	23/95 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433		6/51 (12%)
		COG1340	511..781	CDD:224259	58/279 (21%)
		TIMELESS_C	589..>777	CDD:252956	41/192 (21%)
		SPEC	686..908	CDD:295325	26/105 (25%)
		DUF4515	694..871	CDD:291649	23/97 (24%)
		Ax_dynein_light	<715..780	CDD:287215	18/66 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
fkb-6	NP_508026.1	FKBP_C	26..117	CDD:278674	33/156 (21%)
		TPR_11	254..334	CDD:290150	23/129 (18%)
		TPR repeat	254..282	CDD:276809	6/39 (15%)
		TPR repeat	291..332	CDD:276809	11/71 (15%)
		TPR_11	305..368	CDD:290150	14/63 (22%)
		TPR_1	337..370	CDD:278916	8/33 (24%)
		TPR repeat	337..365	CDD:276809	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810