DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP15 and fkb-4

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	NP_506197.1	Gene:	fkb-4 / 179752	WormBaseID:	WBGene00001429	Length:	259	Species:	Caenorhabditis elegans

Alignment Length:	103	Identity:	25/103 - (24%)
Similarity:	49/103 - (47%)	Gaps:	21/103 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   195 EVGDSLEVAYTGWLFQNHVL----GQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRL 255
            |.||.        ::|.:||    ..:.||:.:::.....:|.:.:||.|.:..|.||.:|.:|.
Worm   164 EAGDK--------IYQQYVLRLEDNTLVDSSYSRNAPFVFRLRNREVIDGMDIAMDGMCEGERRR 220

Human   256 LIVPPACAVGSEG----VIGWTQATDSILVFEVEVRRV 289
            :::|.....||:|    :.|..:     |.||:.:.::
Worm   221 VVIPSEYGYGSQGSPPEIPGGAR-----LFFEIVLEKL 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169
		FKBP_C	193..286	CDD:278674	25/98 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433
		COG1340	511..781	CDD:224259
		TIMELESS_C	589..>777	CDD:252956
		SPEC	686..908	CDD:295325
		DUF4515	694..871	CDD:291649
		Ax_dynein_light	<715..780	CDD:287215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
fkb-4	NP_506197.1	FKBP_C	45..130	CDD:278674
fkb-4	NP_506197.1	FKBP_C	161..250	CDD:278674	25/98 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161456415
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830