DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP15 and fkb-5

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	NP_001367683.1	Gene:	fkb-5 / 171974	WormBaseID:	WBGene00001430	Length:	300	Species:	Caenorhabditis elegans

Alignment Length:	241	Identity:	54/241 - (22%)
Similarity:	85/241 - (35%)	Gaps:	67/241 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    69 MSTPTILVATAVHAY------RYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIH 127
            |:.|.|||   .|::      .:...:.:...||       |...:.|::|..
Worm     1 MTPPFILV---FHSHLFLVWSSFLQLKLISSRKF-------HVGVKMRVILLC------------ 43

Human   128 VNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLSQDLIVADGP 192
                |:|..  |....::|:..|.   :.:...::..:.:...||...|....||.|...::|..
Worm    44 ----LIVAA--YCFAAEEQKLQWK---DEDGLEIKIIRPIKAEKCPIKSQDGDVLDQWYKLSDKD 99

Human   193 AVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLI 257
            ..|:|                      |..|| |.....||.|:||.|.|..|.||.||.||.::
Worm   100 GKEIG----------------------SNFNK-KPYTFTLGKGQVIPGMERAMTGMCKGEKRKVV 141

Human   258 VPPACAVGSEGVIGWTQATDSILVFEVEV----RRV---KFARDSG 296
            :|.....|.:|........|..|.:.|::    |.|   |:..|.|
Worm   142 IPGNLGFGDKGRERDNIKEDQTLYYTVQLVDLFRAVPGEKWTTDEG 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622	15/103 (15%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		15/102 (15%)
		FKBP_C	193..286	CDD:278674	26/92 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433
		COG1340	511..781	CDD:224259
		TIMELESS_C	589..>777	CDD:252956
		SPEC	686..908	CDD:295325
		DUF4515	694..871	CDD:291649
		Ax_dynein_light	<715..780	CDD:287215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
fkb-5	NP_001367683.1	FKBP_C	79..171	CDD:395196	32/114 (28%)
fkb-5	NP_001367683.1	FKBP_C	202..291	CDD:395196
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161456416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840