DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FKBP15 and fkbp15

DIOPT Version :9

Sequence 1:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens
Sequence 2:	XP_031746874.1	Gene:	fkbp15 / 100496235	XenbaseID:	XB-GENE-6035907	Length:	1398	Species:	Xenopus tropicalis

Alignment Length:	1439	Identity:	603/1439 - (41%)
Similarity:	798/1439 - (55%)	Gaps:	261/1439 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTA 65
            ||  |||:||||:||:|||:||||||:||:.:|.|||.||||||||||||.|  |||.:....:.
Frog     1 MF--GDEEDTDFISPTGGAKLASLFGMDQSTSGQGNESFQYTAPKQPKKGPG--ATGGKPNKPSG 61

Human    66 PATMST-PTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVN 129
            ||...| |.:|.|||||||||.|||||||||||.||||||||:|||||||:|||||||.|:||..
Frog    62 PAGSGTAPAVLFATAVHAYRYINGQYVKQGKFGFAVLGNHTAKEYRILLYVSQQQPVTAAKIHPG 126

Human   130 FELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDAVLSQDLIVADGPAV 194
            |...|:||:|:.|||||||:||:|||||.|||:|:|||.:|||||:.:||.|:.|||:..:|.|.
Frog   127 FVFTVQPNHYAAFYDDQRQSWSVMFESEAAAVDFSKQVGVAKCNSSPALDTVIYQDLLPGEGQAA 191

Human   195 EVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVP 259
            ::||.|||||||||||||.|||||||...|||||||||||||||||||:||||:|||||||:::|
Frog   192 DLGDLLEVAYTGWLFQNHELGQVFDSNVQKDKLLRLKLGSGKVIKGWEEGMLGIKKGGKRLVVIP 256

Human   260 PACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPV 324
            ||...||:||.| ....::.|.|||:::|:| .||.|||..||.|||    ||:...|...|:.:
Frog   257 PALGYGSQGVAG-RIPPNATLAFEVDIKRMK-VRDQGSDRQSVGSRD----SPVSLPDCQPAEML 315

Human   325 VSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQPMLPIL--PPQLDSND 387
            ..||:|:|.|.||||:|.||||:|||||   :||..|||||||||||||||||.:  .||.||:|
Frog   316 PQPPSSVPPKPGEPAIRAKSNSISEQLA---NPDVAKAKLISRMAKMGQPMLPFISGTPQPDSSD 377

Human   388 SEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSHSA 452
            |||||.||.:....||....|:|:....|....|:....|| :|..||..|||||.|..:...:.
Frog   378 SEIEDPNTQRAVPSPVAPLPVRPTPQMNHVPAAQVPPAVPQ-TVPTLQGTSAALMPVGPIQPQAL 441

Human   453 VSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNT 517
            ..|.:..||||.     .||.|.:.::|||.|.|:||..:..|.|||..||:.||||||||||:|
Frog   442 APGISPGFQPYV-----QYPYAQSASTQLQSVAPVYPPQIQTPSHFQAGGDVTSFLMTEARQHST 501

Human   518 EIRMAVSKVADKMDHLMTKVEELQK-HSAGNSMLIPSM-SVTMETSMIMSNIQRIIQENERLKQE 580
            ||||::.|:|||:|.|.:||:.||| :||.:|.|:|.: |:|||::|||:|||||||||||||.|
Frog   502 EIRMSIGKIADKIDTLASKVDNLQKENSASSSHLLPGITSITMESAMIMNNIQRIIQENERLKHE 566

Human   581 ILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEEL 645
            :||||:||||||.||||||.|||:.|::   .|.| ....|...:....:....:||..:...:.
Frog   567 VLEKSSRIEEQNGKISELINRNQKEVQR---CMGK-GQGFQQEVQRCMGKGQGFQQEVQRCMGKG 627

Human   646 AAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDL---------------------------- 682
            .....:|.....|....| :|.:..|:..:...|.::
Frog   628 QGFQQEVQRCMGKGKGFQ-QEVQRCMERGKGSSECEMHGKGEGSSRKCRDAWERDKGSSRKCRDA 691

Human   683 ----------------------------------------------------------------- 682

Frog   692 WERGKGSSRKCRDAWERGKGSSRKCRDAWERGKGSSRKCRYAWKGARVPAGKCRDAWEGKGSSRK 756

Human   683 -----LRGQLTKVQAK---------------LSELQETSEQAQSKFKSEKQNRKQLELKVTSLEE 727
                 .||:.:..:.:               |||:|||||.::::.||||:.|:|||:::::||:
Frog   757 CRDAWERGKGSSRKCRDAWERGKGRNMSLLPLSEVQETSEHSKTRAKSEKETRRQLEVRLSALED 821

Human   728 ELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAE 792
            |::||:.|||:|||:|:|||::|.|||.:||||.:|:|:|.|||:::|||:|:|||   :|||||
Frog   822 EVSDLKAEKENLEKSLAERKRRSQQERQRAEEEQEELRRSLQEEVEELRQVLRKTR---EQAAAE 883

Human   793 QLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRD------AYQQKLVQLQEKCLALQAQ 851
            |:|......|.|.|.:       .:...||..::.||..:      ..:||..:.:|.|.|.: |
Frog   884 QVSSRSRNGQRQSELE-------EQAAQLQPLRDQCAMLERRMAAMLEEQKKSKEKESCSAPE-Q 940

Human   852 ITALTKQNEQHIKEL--------------EKNKSQMSGV----------EAAASDPSEKVKKIMN 892
            ..|| :.|||.:.||              |:.:.|||.:          ||..:|.:|:||||||
Frog   941 ALAL-RLNEQKVAELQEQAAQLQPLREKYERLRGQMSALLEEQTKWQSQEAPGTDTTEEVKKIMN 1004

Human   893 QVFQSLRREFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQE-KEESSSEEEEEKAEER----- 951
            :|||.||.||||||.|:||.:|||||:|||..|||||.|.:.| ..:||.|||||:.|:.
Frog  1005 RVFQGLRGEFELEEMYSGREVLGTIMSTIKATTLQLLKQNQPEAAPQSSGEEEEEEDEDEAQVVS 1069

Human   952 --PRR------------PSQEQSASASSGQPQAPL------NRERPESPMVPSEQVVEEAVPLPP 996
              ||.            |.::.::.|:|.:..|.|      ..||.|......|||.|:... |.
Frog  1070 PAPRAAVVPPDQEGNSDPKEDWASGAASEEASAALGEHGEAEEERSEGRDFTIEQVGEDGSD-PV 1133

Human   997 QAL-----TTSQDGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMD- 1055
            |.:     .||...|....|.|:..::........||  .:....::..|.:.|.:| |....|
Frog  1134 QVIQENLEETSALVHMMSSDMESSTVTPAPGAGKEPE--HLRGEPLVSDPGATPTDP-GATPTDP 1195

Human  1056 --SECEESLAASPMAAKPDNPSGKVCVREVAP----DGPLQESSTRLSLTSDPEEGDPLALGPES 1114
              :..:.....:.:.|.|..|..........|    ..|::..:|.....:.|.|..|:|....|
Frog  1196 GATPTDPGATPTDLGATPIEPRATPIEPRATPIEPRATPIEPRATPTDPRATPTEAHPVAHDLRS 1260

Human  1115 PG-EPQPPQLKKDDVTSST------------GPHKELSSTEAGSTV-AGAALRPSHHSQRS---- 1161
            .. .|..||.:..:..||.            ||....|..|.||.| ...|.|||....|:
Frog  1261 HSRSPVAPQTQDSETPSSAADGGNLEDGKLEGPPPLGSDEETGSPVPPPLAQRPSAKPDRAQTQM 1325

Human  1162 ---------------SLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRPPPTPLFGDD-D 1210
                           .|...::::|||...:|....|.: |||:|:||||||.|||.|||||| :
Frog  1326 ERPLAEPKQKQKMNIGLEESDDEDLFKTPPIKPQGSKPE-EEEEEEEVSMKGCPPPAPLFGDDEE 1389

Human  1211 DDDDIDWLG 1219
            ||||:||||
Frog  1390 DDDDLDWLG 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66		14/24 (58%)
		PH-like	70..168	CDD:302622	73/98 (74%)
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169		73/96 (76%)
		FKBP_C	193..286	CDD:278674	65/92 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		27/54 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433		21/51 (41%)
		COG1340	511..781	CDD:224259	129/384 (34%)
		TIMELESS_C	589..>777	CDD:252956	73/300 (24%)
		SPEC	686..908	CDD:295325	104/266 (39%)
		DUF4515	694..871	CDD:291649	80/196 (41%)
		Ax_dynein_light	<715..780	CDD:287215	36/64 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761		14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219		97/359 (27%)
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399	8/60 (13%)
fkbp15	XP_031746874.1	FKBP_C	194..283	CDD:395196	64/89 (72%)
		PHA03247	<293..480	CDD:223021	92/199 (46%)
		Mplasa_alph_rch	<513..>590	CDD:275316	52/76 (68%)
		Smc	<788..>1012	CDD:224117	97/235 (41%)
		PHA03307	1069..>1383	CDD:223039	75/318 (24%)
		Vip_LPXTG_Lm	<1153..1278	CDD:380203	23/127 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I4191
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H28743
Inparanoid	1	1.050	828	1.000	Inparanoid score	I4200
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376380at33208
OrthoFinder	1	1.000	-	-		FOG0009593
OrthoInspector	1	1.000	-	-		oto158510
Panther	1	1.100	-	-	LDO	PTHR44927
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9941
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160