Protein Alignment ACSL6 and Fatp2

DIOPT Version :10

• Sequence 1: NP_056071.2
• Gene: ACSL6 / 23305
• HGNCID: 16496
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_995925.2
• Gene: Fatp2 / 37657
• FlyBaseID: FBgn0265187
• Length: 714
• Species: Drosophila melanogaster
• Alignment Length: 685
• Identity: 139/685 - (20%)
• Similarity: 240/685 - (35%)
• Gaps: 206/685 - (30%)

Human   122 RRGLSISGNGPCLGFRKPKQP---------YQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGV 177
            |:.|:|   |........:||         .|| ::::|.:.:..:.:....|..|  ....:|:
  Fly   136 RKNLNI---GDIFESNVARQPDKLAIVSESQQW-TFRQVNEHSNRVANVFHSHGYK--KGDVVGL 194

Human   178 FAQNRPEWIIVELACYTYSMVVVPLYDT-LGPGAIRYIINTADISTVIVDKP-QKAVLLLEHVER 240
            ..:||.|::...|...... |:.||.:| |...::::.|.....:.:|.... :.||:.:    .
  Fly   195 LLENRAEFVATWLGLSKIG-VITPLINTNLRGASLQHSITVGQCTALIYGASFRSAVMDI----A 254

Human   241 KETPG-LKLIILMDPF-EEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPD--DLSIVCFT 301
            |:.|. :.|....|.. :|.:...|...|:. :.:..:.:...::..|....:.|  |..:..:|
  Fly   255 KDLPAHVGLYQFNDESNQEVVASEGLSQGLA-QQLNGLLETAAKDKVAAGASRADHHDKLVYIYT 318

Human   302 SGTTGNPKGAMLTHGN---VVADFSGFLKVTESQWAPTCADVHISYLPLAHM---FERMVQSVVY 360
            |||||.||.|::||..   :.|.....|...:.       ||..:.|||.|.   ...|.|::::
  Fly   319 SGTTGLPKAAVITHSRYFFIAAGIHYTLGFKDQ-------DVFYTPLPLYHTAGGVMSMGQALLF 376

Human   361 CHGGRV---------GFFQGDIRL-------LSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTP 409
              |..|         |:|....|.       :.:..:.:..|  |..|...|.....:|.....|
  Fly   377 --GSTVVIRKKFSASGYFSDCARFQCTVGQYIGEMARYILAT--PSAPHDRNHQVRMVFGNGLRP 437

Human   410 LKRW--LLEFAAKRKQAEV------RSGIIRNDSIWDELFFNKIQASLG--GCVRMIVTGAAP-- 462
             :.|  .:|....||..|.      .:.|:.|||            ::|  |.:..|:....|
  Fly   438 -QIWPQFVERFGIRKVGEFYGATEGNANIMNNDS------------TVGAIGFISRILPQIYPIS 489

Human   463 ---ASPTVLGFLRAALG-CQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELN 523
               |.|.....||.:.| |:            .|....||.:. |.:....||.       |.|.
  Fly   490 IIKADPHTGEPLRNSQGLCE------------RCEADEPGVFV-GKIVRGNPCR-------EFLG 534

Human   524 YWACKGEG-----EICVRGPNVF----------KGYLKDPDRTKEALDSDGWLHTGDIGKWLPAG 573
            |...|...     ::..:|...|          :|||...||            |||..:|
  Fly   535 YVDQKASSKKVVHDVFSKGDMAFISGDLLVADERGYLYFKDR------------TGDTFRW---- 583

Human   574 TLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSL-----KAFLVGIVVPDPEV- 632
                           :||.|:..::|...........:.|:|.|:     :|.:..|..|..||
  Fly   584 ---------------KGENVSTSEVEAQLSNLAGYKDVIVYGVSIPNTEGRAGMAAIYDPTREVN 633

Human   633 -----------MPSWA--------QKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQV 678
                       :|::|        :|..:.||:       .|:|..|:       :.|.:  .::
  Fly   634 VSQLGVELAKSLPNYARPQFLRFLRKIDLTGTF-------KLRKVELQ-------QQGFN--PEI 682

Human   679 KAIHIHSDMFSVQ-NGL---LTPTL--KAKRPELR 707
                |..::|..| :|:   |||::  :..|.|||
  Fly   683 ----IDDELFYAQPDGVYAPLTPSVYERIVRNELR 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL6	NP_056071.2	LC-FACS_euk	141..719	CDD:341250	135/666 (20%)
Fatp2	NP_995925.2	Adenylate forming domain, Class I superfamily	163..680	CDD:473059	122/616 (20%)