Protein Alignment UBR2 and UBR1

DIOPT Version :10

• Sequence 1: XP_011512740.2
• Gene: UBR2 / 23304
• HGNCID: 21289
• Length: 1782
• Species: Homo sapiens
• Sequence 2: NP_011700.1
• Gene: UBR1 / 853096
• SGDID: S000003416
• Length: 1950
• Species: Saccharomyces cerevisiae
• Alignment Length: 1940
• Identity: 389/1940 - (20%)
• Similarity: 700/1940 - (36%)
• Gaps: 571/1940 - (29%)

Human   126 CGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRY--RMTTSGGGGFCDCGDTEAWKEGP 188
            |||.||:|||.|.|.:|..|.|||||:.||....|.:|..  .:.|....|.|||||.|||....
Yeast   123 CGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHVCTDICTEFTSGICDCGDEEAWNSPL 187

Human   189 YCQKHE---------LNTSEIEEEE---DPL-VHLSEDVIARTYNIFAITFRYAVEIL-TWEKE- 238
            :|:..|         ...::|:||:   |.: :.|.|.|:|..::.|...|...:|.| |.:|:
Yeast   188 HCKAEEQENDISEDPATNADIKEEDVWNDSVNIALVELVLAEVFDYFIDVFNQNIEPLPTIQKDI 252

Human   239 ----SELPADLEMVEKS---------------------------------------DTYYCMLFN 260
                .|:....:|.|::                                       :.|..:::|
Yeast   253 TIKLREMTQQGKMYERAQFLNDLKYENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYN 317

Human   261 DEVHTYEQVIYTLQKAVNCTQKEAIGFATT-VDRDGRRSVRYGDFQYCEQ-AKSVIVRNTSRQTK 323
            ||.|.|.|....|::.|  .....|...|: :|.:||..::      |.| ..||:....:.||.
Yeast   318 DEYHNYSQATTALRQGV--PDNVHIDLLTSRIDGEGRAMLK------CSQDLSSVLGGFFAVQTN 374

Human   324 PLKVQVMHSSIVAHQNFGLKLLSWLGSIIG---------YSDGLRRILCQVGLQ----------- 368
            .|...:...|...||.....::.|:...:.         :.:.:.:.||...|.
Yeast   375 GLSATLTSWSEYLHQETCKYIILWITHCLNIPNSSFQTTFRNMMGKTLCSEYLNATECRDMTPVV 439

Human   369 -----------------------EG-----------PDGENSSL-------------------VD 380
                                   :|           |:....||                   :.
Yeast   440 EKYFSNKFDKNDPYRYIDLSILADGNQIPLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQ 504

Human   381 RLMLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDREF-SVADL 444
            .::..|::.||..|.....:.:.:|.....||.:|..:..:.:..:.......|.:.:. ::.:.
Yeast   505 HILYFDNRYWKRLRKDIQNVIIPTLASSNLYKPIFCQQVVEIFNHITRSVAYMDREPQLTAIREC 569

Human   445 SVQIFTVPSLARMLITEENLMSIIIKTFMDHLRHRDAQGRFQFERYTALQAFK-----------F 498
            .||:||.|:.|:.:...::.:.|:                     ::.:..||           :
Yeast   570 VVQLFTCPTNAKNIFENQSFLDIV---------------------WSIIDIFKEFCKVEGGVLIW 613

Human   499 RRVQSLILDLKY------------VLISKPTEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQV 551
            :|||...|...|            .|:||..:.:..||.|.:   .:.|.|.|...|...|.|:.
Yeast   614 QRVQKSNLTKSYSISFKQGLYTVETLLSKVHDPNIPLRPKEI---ISLLTLCKLFNGAWKIKRKE 675

Human   552 GQHIEMEPE--------WEAAFTLQMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGGYT 608
            |:|:..|.:        ..:.:::......|....:|  :.|.|:.:.|.:...:.|
Yeast   676 GEHVLHEDQNFISYLEYTTSIYSIIQTAEKVSEKSKD--SIDSKLFLNAIRIISSFL-------- 730

Human   609 DGEQPITLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPE----LLPLSE 669
             |.:.:|..:...|.|.|::.||.|:|:...|:..:|:.|...:|..: ||:..|    .|.:|:
Yeast   731 -GNRSLTYKLIYDSHEVIKFSVSHERVAFMNPLQTMLSFLIEKVSLKD-AYEALEDCSDFLKISD 793

Human   670 LSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREM--FDKDVVMLQTGV--S 730
            .|        ||.:|||:|:..|.|.|||.|:::|..||.|   ..|:  :.:|:.:.|..:  .
Yeast   794 FS--------LRSVVLCSQIDVGFWVRNGMSVLHQASYYKN---NPELGSYSRDIHLNQLAILWE 847

Human   731 MMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHKDVVQQN--NTLIEEMLYLIIMLVGER-- 791
            ..|....:..:|.|:||.      |:   |:.|:.::..|.::  :.:|::.:..|..::.||
Yeast   848 RDDIPRIIYNILDRWELL------DW---FTGEVDYQHTVYEDKISFIIQQFIAFIYQILTERQY 903

Human   792 ---FSPGVGQVNATDEIKREIIHQLSIKPMAHSELVKSLPEDENKE-TGMESVIEAVAHFKKP-G 851
               ||.  .:....|:||..||:.|.:||:::|:|::|:|:...:: |..:..:|.|:.|.:| |
Yeast   904 FKTFSS--LKDRRMDQIKNSIIYNLYMKPLSYSKLLRSVPDYLTEDTTEFDEALEEVSVFVEPKG 966

Human   852 LTGRGMYELKPEC-AKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASL 915
            |...|:::||... ||...|...:.....:|.|...:..|.:...|   :...||.|       .
Yeast   967 LADNGVFKLKASLYAKVDPLKLLNLENEFESSATIIKSHLAKDKDE---IAKVVLIP-------Q 1021

Human   916 VNILQSD-------------VMLCIMGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEEK--QH 965
            |:|.|.|             |...::..:||..::..    ..:.|..:|||:....::::  ..
Yeast  1022 VSIKQLDKDALNLGAFTRNTVFAKVVYKLLQVCLDME----DSTFLNELLHLVHGIFRDDELING 1082

Human   966 LENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAVKKMR 1030
            .:::.|.:         :|||         |..:|.::.||......:.::|   |....::||.
Yeast  1083 KDSIPEAY---------LSKP---------ICNLLLSIANAKSDVFSESIVR---KADYLLEKMI 1126

Human  1031 ESSPTSPVAETEGTIMEESSRD-KDK----------AERKRKAEIARLRREKIMAQMSEMQRHFI 1084
            ...|.........:...:...| |||          .|::||..:|:..:.:::|:.:..|..|:
Yeast  1127 MKKPNELFESLIASFGNQYVNDYKDKKLRQGVNLQETEKERKRRLAKKHQARLLAKFNNQQTKFM 1191

Human  1085 DENKELFQQTLELDASTSAVLDHSPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESR 1149
            .|::..|.:                  .|..:..:|   .:|.|...| ||.|||:......
Yeast  1192 KEHESEFDE------------------QDNDVDMVG---EKVYESEDF-TCALCQDSSSTDF--- 1231

Human  1150 AMVLAAFVQRSTVLSKNRSKFIQDPEKYDPL------------FMHPDL--------SCGTHT-- 1192
             .|:.|:...|.:.   |...|.:|.::.|:            ::..|:        |||:..
Yeast  1232 -FVIPAYHDHSPIF---RPGNIFNPNEFMPMWDGFYNDDEKQAYIDDDVLEALKENGSCGSRKVF 1292

Human  1193 SSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNI 1257
            .||.|.:|.:|::||   ||.|.              ..:..|:||||:..||..:||....:..
Yeast  1293 VSCNHHIHHNCFKRY---VQKKR--------------FSSNAFICPLCQTFSNCTLPLCQTSKAN 1340

Human  1258 FNNRLNFSDQPNLTQWIRTISQQIKALQFLRKEESTPNNASTKNSENVDELQLP--EGF------ 1314
            ....|:...:..|:  :.|:|:..|..        |..|..|.||  :..|.:.  :||
Yeast  1341 TGLSLDMFLESELS--LDTLSRLFKPF--------TEENYRTINS--IFSLMISQCQGFDKAVRK 1393

Human  1315 RPDF------------------------RPKIPYS-----------ESIKEMLTTFGTATYKVGL 1344
            |.:|                        |.:.|||           :::|.:|......|:.:|.
Yeast  1394 RANFSHKDVSLILSVHWANTISMLEIASRLEKPYSISFFRSREQKYKTLKNILVCIMLFTFVIGK 1458

Human  1345 KVHPNEEDPRVPIMCWGS---CAYTIQSIERILSDEDKPLFGPLPCRLDDCLRSLTRFAAAHWTV 1406
            .....|..|:.|...|..   ..|.::|          .||.|:..| .....:||.|:.....
Yeast  1459 PSMEFEPYPQQPDTVWNQNQLFQYIVRS----------ALFSPVSLR-QTVTEALTTFSRQFLR- 1511

Human  1407 ASVSVVQG-----HFCKLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDFSGISLGT 1466
               ..:||     ...||:|....                   :|.||.               .
Yeast  1512 ---DFLQGLSDAEQVTKLYAKASK-------------------IGDVLK---------------V 1539

Human  1467 GDLHIFHLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYTGSALKEIPSGWHL 1531
            .:..:|.|.|::.:         ...|:|.|:          .:|...:.:   .||
Yeast  1540 SEQMLFALRTISDV---------RMEGLDSES----------IIYDLAYTF---LLK-------- 1574

Human  1532 WRSVRAGIMPFLKCSALFFHYLNGVPSPPD---IQVPGTSHFEHLCSYLSLPNNLICLFQENSEI 1593
                  .::|.::...:|...|:.:....:   :.:.|....|.|            .|::.:|.
Yeast  1575 ------SLLPTIRRCLVFIKVLHELVKDSENETLVINGHEVEEEL------------EFEDTAEF 1621

Human  1594 MNSLIESWCRNSEVKRYLEGERDAIRYPRESN---------KLINLPEDYSSLINQASNF----- 1644
            :|..::.......:...|..:...:.:|...|         |||:|.:..::.:.|:...
Yeast  1622 VNKALKMITEKESLVDLLTTQESIVSHPYLENIPYEYCGIIKLIDLSKYLNTYVTQSKEIKLREE 1686

Human  1645 -SCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAH-TYSCGSGVGIFLRVRECQ 1707
             |......|......:||.||         .:..|.. |....|.| ..:|....|.||.....:
Yeast  1687 RSQHMKNADNRLDFKICLTCG---------VKVHLRA-DRHEMTKHLNKNCFKPFGAFLMPNSSE 1741

Human  1708 V-LFLAGKTKGCFYSPPYLDDYGETDQ-GLRRGNPLHLCKERFKKIQKLWHQHSV 1760
            | |.|.......|.|.|||:.:||..: .:|||:...|..:|::.:.:||..:.:
Yeast  1742 VCLHLTQPPSNIFISAPYLNSHGEVGRNAMRRGDLTTLNLKRYEHLNRLWINNEI 1796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBR2	XP_011512740.2	UBR-box_UBR2	125..194	CDD:439077	32/69 (46%)
		ClpS	249..327	CDD:460621	22/118 (19%)
		RING-H2_UBR2	1134..1249	CDD:438347	33/136 (24%)
		PRT6_C	1337..1755	CDD:465944	78/446 (17%)
UBR1	NP_011700.1	UBR-box_UBR1_like	123..190	CDD:439070	31/66 (47%)
		ClpS	308..>358	CDD:469998	14/57 (25%)
		RING-H2_UBR1-like	1286..1332	CDD:438145	19/62 (31%)
		PRT6_C	1402..1793	CDD:465944	86/497 (17%)