Protein Alignment UBR2 and ubr11

DIOPT Version :10

• Sequence 1: XP_011512740.2
• Gene: UBR2 / 23304
• HGNCID: 21289
• Length: 1782
• Species: Homo sapiens
• Sequence 2: NP_594298.1
• Gene: ubr11 / 2542809
• PomBaseID: SPAC15A10.11
• Length: 2052
• Species: Schizosaccharomyces pombe
• Alignment Length: 2231
• Identity: 468/2231 - (20%)
• Similarity: 794/2231 - (35%)
• Gaps: 741/2231 - (33%)

Human    59 TDLTREVYQHLAHYVPKIYCRGPNPFPQKEDMLAQHVLLGPMEW-YLCGEDPA-----FGFPKLE 117
            |.|.:||:..|.:|              .||           .| |...|.|.     |...:|
pombe    39 THLLQEVFLSLLNY--------------NED-----------NWKYFLKEKPGAITSDFRLSRL- 77

Human   118 QANKP------------SHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTS 170
            |.::|            |.:||.||:.||..|.|::|.:|.|||||..||..:.|..|...::.|
pombe    78 QHSEPECAQELQDKRSGSKVCGHVFRAGEVIYRCKNCGLDNTCVLCAPCFHATNHEGHETHVSIS 142

Human   171 GG-GGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDP--------------LVHLSEDVIARTYN 220
            .. .|.|||||.|||.....|:.|  |..:.||::.|              .:|:..|.|...::
pombe   143 TSYSGICDCGDPEAWNVDLNCKIH--NVPDDEEQKKPEEVIPLELQHSIRTTIHILLDFILDVFS 205

Human   221 IFAITFR---YAVEILTWEKESELP------ADLEMVEKSDTYYCMLFNDEVHTYEQVIYTLQKA 276
            ...:..:   ....||..|:.|.|.      ||    ...:.:..||:||||||::.|:.::.:|
pombe   206 CSPVNLKAQSTVGSILADEEASRLSSAKYGVAD----RPCNVFRVMLWNDEVHTFDAVVGSVLEA 266

Human   277 VNCTQ-------------------------KEAIGFATTVDRD---------------------- 294
            ::.:.                         .|||..|..:.::
pombe   267 LDSSNTAFGLEVAQRVDSIGRFAVATSASVHEAIRIANAISKENLAVNVRTARDFFREDICGILL 331

Human   295 -------------------------------------GRRSVRYG--------------DFQYCE 308
                                                 .:..|.:.              |....|
pombe   332 EWFDDLLESHVCYFADYLQIIVCDEILKNWSPGLEKPAKPEVNFNNLPLEIVNDDDSEDDIYAAE 396

Human   309 QAKSVIV---------------------------------------------------------- 315
            :...||.
pombe   397 ELLDVIANLQDETGVTRIANLGGDEDFEADMTDPTIAGFDHPLDDDNDVNDLLDFETEREDIDDL 461

Human   316 ---------------------RNT--------------------SRQTK------------PLKV 327
                                 |||                    |:.|:            |:..
pombe   462 TDEVMETEENEAAEADYPGVNRNTRQDDVQDISMETESQNETDESQNTENVDYNPQTHTPVPIPT 526

Human   328 QVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRR----ILCQVGLQEG---------PDG----EN 375
            ......:.....|..:||:.|..||   :..||    .:|||.|:|.         |..    |:
pombe   527 TATQDVVTIRPEFNSQLLNNLRQII---NARRRPRPAAVCQVSLREDYWKSPHPIPPSSYSFVES 588

Human   376 SSLVDRL---MLSDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDR 437
            .|.:.||   :|.|.|.||..|.:..:|::.....:|.:|:|..:||..:|..|.:.::..|.:.
pombe   589 PSSILRLDYFLLFDLKFWKRLRGLLSKLYVVPFNRNLLFKRLMGIRFVIHYRSLATAFLFADREP 653

Human   438 EFSVADLSVQIFTVPSLARMLITEENLMSIIIKTFMDHLRHRDAQGR-FQFE-RYTAL-----QA 495
            :.||..||||.||.||||..::.:.:.::.:..|.:..|...:.... |..: .||..     |.
pombe   654 DHSVMFLSVQFFTTPSLAEAVVKDYDFLTNLNATTLSLLTQSNRPSTLFSSDIEYTPTIQLNRQV 718

Human   496 FKFRRVQSLILDLKYVL----ISKPTEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIE 556
            .|.||..:|..||.|:|    :.|..  .|:.|.     ...:::||:..||:.|..|.:..|:
pombe   719 LKTRRTYNLFSDLGYLLQHPQVKKLV--VDDTRY-----VHQYIDLLRVFQGVIPQQRAILSHV- 775

Human   557 MEPEWE------AAFTLQMKLTHVISMMQDWCAS-----DEKVLIEAYKKCLAVLMQCHGGYTDG 610
               :|:      ..|.:|.     ::|:.:..:|     ..:.|..|.|..:..:........:.
pombe   776 ---QWDFPHGKNILFVMQR-----VAMLSNTVSSCFTQAPYERLFYAIKCIITSITHPKLDIAES 832

Human   611 EQPITL----SICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELS 671
            .:|::.    |:...:...:.:.||::.:|.:.|:..:|:.|.........::...:.|
pombe   833 LEPLSCIPSSSLTNFTQPLVPFSVSRDPISFYHPLHWMLSNLFSYCRVDASSHWDKDTL------ 891

Human   672 PPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDVVMLQTGVSMMDPNH 736
             ..|::||||..||.||:...:|.|||.|::....:|..:......:|||::.:||.:..:|||.
pombe   892 -LALLDHPLRVCVLLAQIDCNLWIRNGRSILLTDAFYRQLNNIEVSYDKDILAIQTILMFVDPNL 955

Human   737 FLMIMLSRFE----LYQIF--STPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPG 795
            .|..::.|||    ||.:.  ..|:|.            .::...::.:||.|:|.|:.||  ..
pombe   956 VLNAVVQRFEFTDWLYNLTYNEHPNYD------------TERIPAMLCKMLELLIALITER--EQ 1006

Human   796 VGQVNATDEIKREIIHQLSIKPMAHSELVKSLPEDENKETGMESVIEAVAHFKKP-GLTGRGMYE 859
            :..|:..|.|:..:..||...|:|:|.|:.::..:..:....:.:.|.|..:|.| ||...|:|.
pombe  1007 ILHVDIQDIIRTRLAQQLCFGPLAYSALLSTISSNLVESLSFDKIREEVTSYKAPDGLHDFGVYS 1071

Human   860 LKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQ--NREDTALPPPVLPP-------------FC 909
            ||.|.....:.|::|:::.|:   ||:...||::  .:.:.:....::.|             |.
pombe  1072 LKDEYYDLVDPYYFHYNKNER---EESDTILKKRLAKKNNVSAESIIIEPKIRFLEKDGHDIFFA 1133

Human   910 PLFASLVNIL----------------QSDVMLCIMGTILQWAVEHNGYAWSESMLQRVLHLIGMA 958
            .:.||..:::                .||:...|:|..||                  |.||.|.
pombe  1134 AVNASTFSLIIFRAIEYALVQAESFGSSDIGNTILGDALQ------------------LCLISMK 1180

Human   959 LQEEKQHLE----NVTEEHVVTFTFTQKISKPGEAPKNSPSILAML--ETLQNAPYLEVHKDMIR 1017
            :.|..:..:    :..|.:....:..::..       .|...||.|  ..|::..|.:||
pombe  1181 IHEFSKSNDFCSRSCAERYPTDSSIMREFG-------GSAYCLAELCFAILKSPKYKDVH----- 1233

Human  1018 WILKTFNAVKKMRESSPTSPVAETEGTIME----ESSRDKDKAER-KRKAEIARLRREKIMAQMS 1077
              :|....:..::::.|::.....|.|..|    .|:.|.::.|: :.|..:|..:::|||.|..
pombe  1234 --VKVNAVLAGLQKNDPSAYSNMLEATHFELSTTSSTSDSNEIEKTQEKKRLALEKQKKIMQQFR 1296

Human  1078 EMQRHFIDENKELFQQTLELDASTSAVLDHSPVASDMTLTALGPAQTQVPEQ----RQFV--TCI 1136
            :.|..|:.:|.:.                  .:..|.|...:   .|:.||:    .:.:  .|:
pombe  1297 DQQASFLAQNTDF------------------DIGEDQTEDEV---TTEEPEEEVKYHEHIRGNCL 1340

Human  1137 LCQEEQEVKVESRAMVLAAFVQRSTVLSKN--RSKFIQDP------------------EKYDPLF 1181
            |||||..   :.....:...:|.|::|.|.  .|:.|.|.                  :|||.:.
pombe  1341 LCQEECN---DQAPYGVIGIIQGSSLLRKTDVHSEIILDEIYSVPPNLDRESHSRPFGKKYDTVV 1402

Human  1182 MHPD----LSC--------GTHTSSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENG- 1233
            .:..    ||.        |...|.|||:||..|::.|:   .|:...|.         ||..|
pombe  1403 FNRSKDRLLSAYPPGNNIRGVFVSGCGHLMHLGCFKNYY---VARSMYRN---------DVTAGL 1455

Human  1234 -----------EFLCPLCECLSNTVIPLLLPPRNIFN-NRLNFSDQPNLTQW---IRTISQQIKA 1283
                       .|:||||..|||.::|:...|:...| :.|||....|  .|   |.|:|.....
pombe  1456 SEYYYKYSTAKFFMCPLCRSLSNVLLPMPQIPKMCLNIDTLNFPRSMN--GWLEEIGTMSSSSFE 1518

Human  1284 LQFLRKEESTPNNASTKNSENVDELQLPEGFRPDF-RPKIPYSESIKEMLTTFGTA--------- 1338
            .|.:|...|     .||::           ||..| ||.| .|:.|..||.....|
pombe  1519 YQLVRSSLS-----DTKDT-----------FRSCFLRPWI-NSKIISAMLARLKIADGALIDQSN 1566

Human  1339 -------------TYKVGLKVHPNEEDPRV-PIMCWGSCAYTIQSIE--------------RILS 1375
                         |.|:.:|:........| |.....|.|||:.|:|              .:..
pombe  1567 NRDVSDLYDRYCETTKLAMKLVKGSTFTNVSPHDLLNSLAYTVSSLEVSQRCSPKQSGATRSVWF 1631

Human  1376 DEDKPL---FGP------LPCRLDDCLRSLTRFAAAHWTVASVSVVQGHFCKLF------ASLVP 1425
            :|..||   |.|      |.|..|..::|..:   |...:.|..::   .||:|      .|::.
pombe  1632 NELGPLTLSFLPTLSDTVLKCVCDQIIKSDQQ---ALLLMESQKLL---VCKIFYRHSQLKSMLR 1690

Human  1426 N---DSHEEL-PCILD--IDMFHLLVGLVLAFPALQCQDFSGISLGTGD-----LHIFHL----V 1475
            |   ..|::: |.:|.  .|.|..:..|:|.|             |..|     :.:|:|    .
pombe  1691 NGRMSDHDQIQPFLLSNTFDDFVKISSLMLIF-------------GKQDNILYYVKLFYLSEICK 1742

Human  1476 TMAHIIQILLTS----------------------------CTEENGMDQENPPCEEESAVLALYK 1512
            |:..:|:::..|                            |...|.::    ..::||.:|.|..
pombe  1743 TIISMIKVVADSSVVPDLTINYSQQSKSQFYILCKNVLLWCGSSNNIE----ILDDESNLLRLMS 1803

Human  1513 TLHQYTGSALKEIPSGWHLWRSVRAGIMPFLKCSALFFHYL-------NGVPSPPDIQVPGTSHF 1570
            .:.:|:                     :|||:..||..:.:       |...:..|     .|..
pombe  1804 LVEKYS---------------------LPFLRRVALVLYCMFDISLEFNEFSNNED-----DSEL 1842

Human  1571 EHLCSYLSLPNNLICLF-----QENSEIMNSLIESWCRNSEVKRYLEGERD-AIRYPRESNKLIN 1629
            |.|...:.:| .|..|:     .||::|: .||..||.:.....:  |:.. ::.|| ...:|:.
pombe  1843 ERLSKLIKVP-PLQELYSQMSSDENNQIL-ELIAGWCEHLAQNTW--GDSTISLEYP-GIYELVK 1902

Human  1630 LPEDYSSLINQASN---FSCPKSGGDKSRAPTLCLVCGSLLC---SQSYCCQTELEGEDVGACTA 1688
            ||....:||:....   ..|.|:    ...|.:|::|||::|   .|:......|.||    |..
pombe  1903 LPHRLENLIDSMQESVCCMCHKT----PILPAICMLCGSVICFNARQNTVSSRRLTGE----CNK 1959

Human  1689 HTYSCGSGVGIFLRVRECQVLFLAG-KTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFK-KI 1751
            |..:|...||||...:.|.:|.|.. ...|.....||||.:||||..||||.|..|.::|:. .:
pombe  1960 HAATCTGSVGIFFITKACGILLLDSISNTGTIMPTPYLDIHGETDLQLRRGCPQFLNQKRYDFVV 2024

Human  1752 QKLWHQHSVTEEIGHAQEANQ 1772
            ::.|.:.:|.:::....:..:
pombe  2025 REQWLRQTVLQKMARHMDMTE 2045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBR2	XP_011512740.2	UBR-box_UBR2	125..194	CDD:439077	30/69 (43%)
		ClpS	249..327	CDD:460621	25/286 (9%)
		RING-H2_UBR2	1134..1249	CDD:438347	40/158 (25%)
		PRT6_C	1337..1755	CDD:465944	116/533 (22%)
ubr11	NP_594298.1	UBR-box_UBR3	95..166	CDD:439071	31/70 (44%)
		ClpS	244..>293	CDD:469998	10/48 (21%)
		RING-H2_UBR1-like	1422..1482	CDD:438145	22/71 (31%)
		PRT6_C	1595..2029	CDD:465944	112/495 (23%)