Protein Alignment KIF13B and KIP3

DIOPT Version :10

• Sequence 1: XP_011542759.1
• Gene: KIF13B / 23303
• HGNCID: 14405
• Length: 1847
• Species: Homo sapiens
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 842
• Identity: 225/842 - (26%)
• Similarity: 346/842 - (41%)
• Gaps: 255/842 - (30%)

Human     4 SKVKVAVRIRPMNRRETDLHTKCV-----------------------------VDVDA------- 32
            |.:.||:|:||....|   .|:.|                             :|:||
Yeast     9 SSIVVAIRVRPFTSME---KTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGSTRS 70

Human    33 --------------------------------------NKV---ILNPVNTNLSKGDAR------ 50
                                                  |||   :||.:....:|..|.
Yeast    71 KRNSLLRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVSDQVLNSMRARATKATASSINNSN 135

Human    51 -------------GQPKVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAY 102
                         |:.| |.:|..|   ||:     :.|..|:|.....:|.:..||:|:.:|||
Yeast   136 ATNKFSSQRRRHGGEIK-FVFDKLF---DET-----SSQARVYKETTSPLLDSVLDGFNSTVFAY 191

Human   103 GQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGS 167
            |.||.||:||:.||..|||:|......||.:. .:..:|:.|::.:||:|||||::||||.|:..
Yeast   192 GATGCGKTYTVSGTPSQPGIIFLAMEELFNKI-TDLKDEKDFEISLSYLEIYNERIRDLLKPETP 255

Human   168 RQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITL-- 230
            .:.|.:||.:.....|..||.....:.:|:..|:.:||.:||.:.|..||.|||||||.:|.:
Yeast   256 SKRLVIREDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQ 320

Human   231 THTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQSA 295
            |:.|.|:   ||......||::||||||||..|...|.||.||:|||:||..||..|:||.....
Yeast   321 TNKLVDL---TSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDG 382

Human   296 GKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVN 360
            .::.:  :|||||.||.|||.|||||.||.|:..:||::.:|||||:||:||:|||.|....:.|
Yeast   383 SRSCH--IPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRN 445

Human   361 EDPNAR-------IIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLR-- 416
            :...:|       :|.:.:.::|:|||:..|..::|..:.|...|:.:..|.|.....::...
Yeast   446 QQSLSRHVGSYLKMITEQKRQIEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQQTYAGV 510

Human   417 KTEEIAQERQKQLESLGIS----LQSSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLIGSAN 477
            :|.::|    |.|:||.:.    ||            :|.|..|   |.:|::..:|.|   :|.
Yeast   511 ETYQVA----KTLKSLILCKRRFLQ------------MVKLEVD---NLILLFEREEST---AAE 553

Human   478 SQD-IQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPI-QLHHGDRILWGNNHFF 540
            .|. |..|.|            ..||:.....:....|....::||.| |:|..|
Yeast   554 MQPVISNCRM------------ISGQLYNKIHELEMKFDETDTLSSVIHQVHSID---------- 596

Human   541 RLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKALGSND 605
             ||     |..|.||.|:                             .|:...:|
Yeast   597 -LN-----KLREMEDWDE-----------------------------TYDLVYLE---------- 616

Human   606 PMQSILNSLE--QQHEEEKRSALERQRLMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPSAQQRL 668
               |.||.:.  |::|....|::..::||.:..|.                .||.|        |
Yeast   617 ---SCLNQISELQRNEILVNSSIMTEKLMSDPGLN----------------SRFKF--------L 654

Human   669 RQWAEEREATLNNSLMRL------REQIVKANLLVREANYIAEELDKRTEYKVTLQIPASSL 724
            .:|...|...:.:.:..|      .|...:..:...::|:....::........|.:||.:|
Yeast   655 SKWLMNRTPNIESIIQDLVHIDEEFESFARTFIANPDSNFTNTNINIINTTAADLAVPAETL 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF13B	XP_011542759.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	152/453 (34%)
		Kinesin_assoc	357..469	CDD:465047	26/124 (21%)
		FHA_KIF13B	447..545	CDD:438782	23/99 (23%)
		COG4913	<611..>760	CDD:443941	21/122 (17%)
		KIF1B	756..802	CDD:463574
		bMERB_dom	<1099..1143	CDD:463467
		DUF3694	<1221..1278	CDD:463599
		PHA03247	<1445..1704	CDD:223021
		CAP_GLY	1725..1788	CDD:460154
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	139/370 (38%)