DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF13B and Kif13b

DIOPT Version :9

Sequence 1:	XP_011542759.1	Gene:	KIF13B / 23303	HGNCID:	14405	Length:	1847	Species:	Homo sapiens
Sequence 2:	NP_998791.1	Gene:	Kif13b / 305967	RGDID:	1303307	Length:	1767	Species:	Rattus norvegicus

Alignment Length:	1884	Identity:	1551/1884 - (82%)
Similarity:	1620/1884 - (85%)	Gaps:	154/1884 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSM 65
            |||||||||||:|||||||.||||||||||:||||||||:||||||||||||||:||||||||||
  Rat     1 MGDSKVKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPINTNLSKGDARGQPKIFAYDHCFWSM 65

Human    66 DESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGL 130
            ||||:|||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 DESVREKYAGQDDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGL 130

Human   131 FERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYK 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 FERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYK 195

Human   196 DIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERA 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 DIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERA 260

Human   261 TKTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTA 325
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
  Rat   261 TKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTA 325

Human   326 MVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKS 390
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
  Rat   326 MVATVSPAADNYDETLSTLRYADRAKHIINHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKS 390

Human   391 PELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDDKCFLVNLNA 455
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   391 PELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFLVNLNA 455

Human   456 DPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSV 520
            |||||||||||||||||||||||||||||||||||||.||||..|||||||||||||||||||||
  Rat   456 DPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGIIDIMPEGQVMLTPQKNTRTFVNGSSV 520

Human   521 SSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEV 585
            ||||||||||||||||||||||||||||||||||||:::.|:||::||||||.|||||||||||:
  Rat   521 SSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEEREASLKNDSSSEQLDADGDSSSEVSSEI 585

Human   586 NFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPEKQN 650
            |||:||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||:||
  Rat   586 NFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPERQN 650

Human   651 CRSMDRFSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREANYIAEELDKRTEYKV 715
            ||.:||.|||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   651 CRGVDRLSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREASYIAEELDKRTEYKV 715

Human   716 TLQIPASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVI 780
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||:||.
  Rat   716 TLQIPASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLENRLLDMRDLYQEWKECEEDSPVS 780

Human   781 RSYFKRADPFYDEQENHSLIGVANVFLESLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGDVG 845
            ||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||.:|
  Rat   781 RSYFKRADPFYDEQENHSLIGVANVFLETLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGAIG 845

Human   846 ERIAGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEPVIVAPEVDTS 910
            |||||||:..|||.|||.|||:|||||||||||||||||.|||||||.||||||||.||||||||
  Rat   846 ERIAGGDDPTEVSSEKEVQENRLVCMVKILQATGLPQHLCHFVFCKYDFWDQQEPVTVAPEVDTS 910

Human   911 SSSVSKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQAKT 975
            ||..||||.||||||||:||||||||||||:||||||||||||||:|||||||||||||||||||
  Rat   911 SSPTSKEPQCMVVFDHCSEFSVNITEDFIEYLSEGALAIEVYGHKMNDPRKNPALWDLGIIQAKT 975

Human   976 RSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQGQSRRVQVEVKSVQE 1040
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat   976 RSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVIAAKDVPTGGIFQLRQGQSRRVQVEVKSVQE 1040

Human  1041 SGTLPLMEECILSVGIGCVKVRPLRAPRTHETFHEEEEDMDSYQDRDLERLRRKWLNALTKRQEY 1105
            |||||||||||||||||||||||||:|:|||..||||||||||||||||||||||||||||||||
  Rat  1041 SGTLPLMEECILSVGIGCVKVRPLRSPKTHENIHEEEEDMDSYQDRDLERLRRKWLNALTKRQEY 1105

Human  1106 LDQQLQKLVSKRDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMETHI 1170
            |||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||.||
  Rat  1106 LDQQLQKLVSKHDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMEAHI 1170

Human  1171 PVIFLDLNADDFSSQDNLDDPEAGGWDATLTGEEEEEFFELQIVKQHDGEVKAEASWDSAVHGCP 1235
            ||:|||||||||||||||||||| |||||||||||||||||||||.||||||||||||||||.||
  Rat  1171 PVVFLDLNADDFSSQDNLDDPEA-GWDATLTGEEEEEFFELQIVKHHDGEVKAEASWDSAVHNCP 1234

Human  1236 QLSRGTPVDERLFLIVRVTVQLSHPADMQLVLRKRICVNVHGRQGFAQSLLKKMSHRSSIPGCGV 1300
            |||:|||.|||:|||:||.|||||||||||||||||||:|||||||||||||||:||||||||||
  Rat  1235 QLSKGTPADERVFLILRVAVQLSHPADMQLVLRKRICVHVHGRQGFAQSLLKKMTHRSSIPGCGV 1299

Human  1301 TFEIVSNIPE-DAQGVEEREALARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVA 1364
            |||||||||| ||||||||||||||||||||.|||||||.|||||||||||||||||||||||||
  Rat  1300 TFEIVSNIPEVDAQGVEEREALARMAANVENAASADSEACIEKYLRSVLAVENLLTLDRLRQEVA 1364

Human  1365 VKEQLTGKGKLSRRSISSPNVNRVSVWNQALCCAWDFSPLLFSWLSGSRQDLIPSYSLGSNKGRW 1429
            |||||||||||:|||||||::||                     ||||||:|.||:||.|||
  Rat  1365 VKEQLTGKGKLNRRSISSPSMNR---------------------LSGSRQELSPSHSLSSNK--- 1405

Human  1430 ESQQDVSQTTVSRGIAPAPALSVSPQNNHSPDPGLSNLAASYLNPVKSFVPQMPKLLKSLFPVRD 1494

  Rat  1406 ----------------------------------------------------------------- 1405

Human  1495 EKRGKRPSPLAHQPVPRIMVQSASPDIRVTRMEEAQP-EMGPDVLVQT---MGAPALKICDKPAK 1555
                         |||||:||....|.|.||.||||. ..||...:::   |.||.:||||||.:
  Rat  1406 -------------PVPRILVQPTFSDARATRTEEAQQGSPGPSGALESMVKMAAPTVKICDKPVR 1457

Human  1556 VPSPPPVIAVTAVTPAPEAQDGPPSPLSEASSGYFSHSVSTATLSDALGPGLD----AAAPPGSM 1616
            |.|||   :...||...|.||||||||||||||||||||||||||:.|..|||    .:..|||.
  Rat  1458 VSSPP---STMVVTQPQEGQDGPPSPLSEASSGYFSHSVSTATLSETLTLGLDTTGLGSQTPGSP 1519

Human  1617 PT------APE-----------AEPEAPISHPPPPTAVPAEEPPGPQQLVSPGRERPDLEAPA-P 1663
            |.      .||           .:||.|...|..||.....|.|.|..|..|        .|| |
  Rat  1520 PALCQVTQEPELAFLSCTQSHPTDPEEPHIPPATPTQSTELEVPRPPLLSDP--------TPAVP 1576

Human  1664 GSPFRVRRVRASELRSFSRMLAGDPGCSPGAEGN---APAPG-AGGQAL-----ASDSEEADEVP 1719
            .||||:|:||.|||.||:.||.   |.|.||:.:   :..|. |.||.|     .||||:|.|||
  Rat  1577 TSPFRIRKVRPSELTSFTGMLG---GASSGAQEDPVVSEDPSHARGQTLGRLEVTSDSEDASEVP 1638

Human  1720 EWLREGEFVTVGAHKTGVVRYVGPADFQEGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYGLLVR 1784
            |||||||:|.||.:|||:|||:||.|||||||:|||||||:||||||||||||||||||||||||
  Rat  1639 EWLREGEYVVVGTNKTGIVRYIGPTDFQEGTWIGVELDLPAGKNDGSIGGKQYFRCNPGYGLLVR 1703

Human  1785 PSRVRRATGPVRRRSTGLR-LGAPEARRSATLSGSATNLASLTAALAKADRSHKNPENRKSWAS 1847
            |.|||||.|..||||:||: .||||||||||:||||||||||||||||.|||:|||||||||||
  Rat  1704 PGRVRRAAGTGRRRSSGLQPQGAPEARRSATISGSATNLASLTAALAKGDRSYKNPENRKSWAS 1767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF13B	XP_011542759.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	346/355 (97%)
		KISc	6..360	CDD:214526	344/353 (97%)
		Kinesin_assoc	357..469	CDD:292801	110/111 (99%)
		FHA	447..544	CDD:238017	93/96 (97%)
		RILP-like	<610..710	CDD:304877	93/99 (94%)
		KIF1B	756..802	CDD:289208	42/45 (93%)
		DUF3585	<1099..1143	CDD:304905	42/43 (98%)
		DUF3694	<1221..1279	CDD:289256	50/57 (88%)
		Jun	<1560..1664	CDD:281890	53/125 (42%)
		CAP_GLY	1725..1788	CDD:279625	52/62 (84%)
Kif13b	NP_998791.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	346/355 (97%)
		KISc	6..360	CDD:214526	344/353 (97%)
		Kinesin_assoc	357..469	CDD:292801	110/111 (99%)
		FHA	447..544	CDD:238017	93/96 (97%)
		KIF1B	756..802	CDD:289208	42/45 (93%)
		C2	<888..>952	CDD:301316	56/63 (89%)
		DUF3585	<1073..1143	CDD:304905	67/69 (97%)
		DUF3694	<1211..1278	CDD:289256	58/66 (88%)
		CAP_GLY	1644..1707	CDD:279625	52/62 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83697008
Domainoid	1	1.000	673	1.000	Domainoid score	I3832
eggNOG	1	0.900	-	-		E2759_KOG0241
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9073
Inparanoid	1	1.050	3128	1.000	Inparanoid score	I468
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D12822at7742
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		oto136281
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310