Protein Alignment EHBP1 and MICAL-like

DIOPT Version :10

• Sequence 1: NP_056067.2
• Gene: EHBP1 / 23301
• HGNCID: 29144
• Length: 1231
• Species: Homo sapiens
• Sequence 2: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Alignment Length: 1037
• Identity: 229/1037 - (22%)
• Similarity: 386/1037 - (37%)
• Gaps: 337/1037 - (32%)

Human   446 SQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDG 510
            :::|..||:.||:.|.|||:.|.||||||||:||||:|||||||||:..|...||.|||..|:..
  Fly    13 TKALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTT 77

Human   511 FAS-IGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETD 574
            ... :||..||:.:|||...:||:|:::|||.|.                      |||
  Fly    78 AEKYLGIPALLDAADMVSYEVPDRLSILTYLSQF----------------------YKV------ 114

Human   575 TNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDD------SVFVNDSGVGESESEHQ---- 629
            ...|:...|....|.:   |.|..|.:...|....:|.      .||:.:..:....:.|:
  Fly   115 LGKSLKHPKPEEPLGE---ESEPPQKVMHIVGMPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLK 176

Human   630 --------TPDDHLSPSTASPYCRRTKSDTEPQ-KSQQSSGRTSGSDDPG----ICSNTDSTQAQ 681
                    ||.........:.||..|..|.|.: :|.....:|:.:|.|.    :..::|.::|:
  Fly   177 CARCSSLLTPGSFYETEVNNIYCCETCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEAE 241

Human   682 VLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQ--KLQTLDIGSNLEKEKL------- 737
            .        |.|.||.:|:..:||.::..||   ...|||  :|....:...|.:|:.
  Fly   242 D--------KQEDLEDNDIRTTDKPENFQPP---SNKDEQNNELTINPVNPILSEERKISFIPLD 295

Human   738 -ENSRSLECRSDPESPIK-------KTSLSP-----------TSKLGYSYSRDLDLAKKKHASLR 783
             |:...:|..:...:|:|       |.|..|           .:.|..|...|:...|.|.:|:.
  Fly   296 EEDGGLIEQYNKSTTPVKPAIPEKPKVSTLPLDDEQHAGVEQNNDLAVSPENDIPKEKLKISSVS 360

Human   784 QTESDPDADRTTLN--HADHSSKIVQHRLLSRQEELKERARVLLEQARR--------DAALK--- 835
            ....|   ||..::  |.|:         |.:||.|...:..|:.:::.        ..|:|
  Fly   361 IYLED---DRLVVDAIHPDN---------LDKQEALNNTSDALIPESQEAPIPENNTQVAIKPED 413

Human   836 -----AGNKHNTNTATPFCNRQ---LSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMA 892
                 ..||..:||.:  |::|   |..|.|       .|..:..:.|    .|.||.....::.
  Fly   414 HISPRKENKIFSNTES--CSKQEGVLPKQMD-------LESPKDKVIE----TKASETDYPEDLN 465

Human   893 AEKLKERSKASG--DENDNIEIDTNEEIP----EGFVV---------GGGDELTNLENDLDTPEQ 942
            ..|..:.||.:.  |.:|: |::..:.||    :|.||         |    |:::.|..:.|..
  Fly   466 PFKDDDSSKGANPFDSSDD-EVELLKAIPAQQSKGKVVPPRPPPPKIG----LSSISNPSEKPHS 525

Human   943 NSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQ--KTTERF----- 1000
            :..|  ...||:....|:::.|.:....|.:|   .|..||......:|.|.  :|.:|.
  Fly   526 SPTL--SHGKKMPMPTPRISISKTQTPAKPMT---HQGQKSSISSSSSEHLNSIRTFDRGADDRG 585

Human  1001 -----------RNPVVFSKDSTVRK------TQLQSFSQYIENRPEMKRQRS----IQED----- 1039
                       |.|:..|..|.:|.      |.|.|.:.     |..|::::    ||.|
  Fly   586 SSISLPSANGPRKPLRASVGSPLRSEESSPTTSLSSITS-----PMRKKRQAPLPPIQTDFDSDP 645

Human  1040 -TKKGNEEKAAITETQRK------------PSEDEVLNKGFKDTSQY------------------ 1073
             ..|.::|:.|:..||.|            |.:..:|:....::|.|
  Fly   646 GFSKLSDEQKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNADEEVNVVYR 710

Human  1074 ----------------------------------------------------------------- 1073
                                                                             
  Fly   711 RILVPPTQPENTVERSKEDQKSPIVYNDFDRNVSPLGHNKSTHGKWKRRKGPAPAVPIPPRKVLQ 775

Human  1074 ------VVGELAALENEQKQIDTRAALVEKRLR-------YLMDTG--------RNTEEEEAMMQ 1117
                  :..|...:..:|..::.:..::||.:|       ...||.        .|::|.|.::.
  Fly   776 RLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSLDATDTDGPESAEVLTNSKEVEDLIL 840

Human  1118 EWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDEL 1182
            :.|.|||:||.|.||..:|..|.::|.||:....:..|:|.::...:..||::.|..|::|::.|
  Fly   841 QLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHNKTDSDKAHEEVLINRL 905

Human  1183 VALVNKRDALVRDLDAQEKQAEEEDEHLE-----------------RTLEQNKGKMAKKEEK 1227
            |.:|..|:.::..|:....:...||..::                 |:.:::..|::|||.|
  Fly   906 VKVVEMRNEVIDSLETDRVREAREDMSIKNRLHIYNSEREEPPAHPRSADKSSKKLSKKERK 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHBP1	NP_056067.2	NT-C2	12..165	CDD:463058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..318
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..440
		CH_EHBP1	444..550	CDD:409103	52/104 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..675		12/75 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..764		7/52 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..800		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	837..865		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	895..941		14/60 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	960..996		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1025..1065		13/61 (21%)
		bMERB_dom	1077..1210	CDD:463467	38/147 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1198..1231		8/47 (17%)
		CAAX motif. /evidence=ECO:0000305|PubMed:27552051	1228..1231		229/1037 (22%)
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	55/129 (43%)
		LIM_like_1	146..207	CDD:188784	10/60 (17%)
		PTZ00449	<411..727	CDD:185628	66/343 (19%)
		bMERB_dom	785..933	CDD:463467	38/147 (26%)