DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EHBP1 and Ehbp1

DIOPT Version :9

Sequence 1:	NP_001341141.1	Gene:	EHBP1 / 23301	HGNCID:	29144	Length:	1231	Species:	Homo sapiens
Sequence 2:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster

Alignment Length:	1315	Identity:	416/1315 - (31%)
Similarity:	627/1315 - (47%)	Gaps:	258/1315 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNP 65
            ||||||||||..|.|:||||.|||.:|.:|.|.||:|..|.:||||||||.:|....|:|.:.||
  Fly     1 MASVWKRLQRNFKRAAKFQFTASYHDLHLETTAKWRPSNLSIVWTRRSRRVASAPLPWEPDMMNP 65

Human    66 YRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPT 130
            ..|.:.||||:|..|:|||||||...|.|||:||||||:.:|.|:::.||.:||||::|||...|
  Fly    66 LVGNISWPVPDNHTISVTLFKDPRTHELEDKDWTFVIEDVTPMGKKRVLANASINMRKYASIEST 130

Human   131 QTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNED 195
            |....|..||:|||:.:|:|:.::||:||||||||||||||:.|:||:...|:..|||.|:..:.
  Fly   131 QQSFTLSLKPVSKKITAASLELTISCVFLREGKATDEDMQSVVSMMSVNNNDVAPLDDLEDIPDL 195

Human   196 DDENRVNQEEKAAKITEIVNQLN----ALSSLDEDQDDCIKQANMRSAKSASSS----EELINKL 252
            |.            .:||.:..|    .|..:....:.||..|..:|..|.|..    .|..|.|
  Fly   196 DG------------FSEITDNFNDFTQQLEHMTTSLNGCIDVATPQSVPSLSEDPTPLAESFNPL 248

Human   253 NFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDS------------EEPI---TETASPRKTE-D 301
            :|  |.:.|.....:|..|.|.||.....|..:|            :.||   .|...|::|. :
  Fly   249 HF--ELDADGKREAANKLDLPTAASGGSSGAEESLKTPNGLQHVVDQTPIKSPDEVKQPKQTPVE 311

Human   302 SFYNNSYNPFKEVQTPQYLNPFDEPE---------AFVTIKDSPPQSTKRKNIRPVDMSKYLYAD 357
            |..:.:...|.::.|...|.|....:         .|.|.|:. .|..:.::::. |.:|.: .|
  Fly   312 SLRSKTNEDFDKMVTSTPLEPNVNKDDVKPKKKRALFFTEKED-EQDLRVESVKE-DTTKTI-GD 373

Human   358 SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETER-----RVKRKAPAPPVLSPKTGVLNEN 417
            :|.|:|:..:||....:..|...|:.....:|.|..::     :....||.|      ..|:||
  Fly   374 NSTTKEKPKEESQSSKDASSVVVPSAKRPELQPLNLKKSYEPSQTPESAPVP------ASVINE- 431

Human   418 TVSAGKDLSTSPKPS----PIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSF 478
              |.|...|||...:    |:...|| ::....|.||.|||||||:|..||:||.|||||||::|
  Fly   432 --SIGSCFSTSGSLNNSLKPVEKIVL-KENTPGQDLLEWCKEVTKDYPNVKVTNLTTSWRNGMAF 493

Human   479 CAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQI 543
            |||:|||.|:|||...|:..|:..|.:..:|...|:||.|::||.||.:|.:||||.|||||:|:
  Fly   494 CAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAESLGIPRVIEPRDMNMLTVPDKLAVMTYLHQL 558

Human   544 RAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSS------------VDQEKFYAELSDLKREPE 596
            ||||:|::|.:.||...:.:|:|.:|:|::|..|.            :.|..|..|::...:..:
  Fly   559 RAHFTGKQLKIEQIGSTADESSYVIGDYKSDNLSQNRINFSHPKSLLLHQNSFDEEINGSNKSEQ 623

Human   597 L----QQPISGAVDFLSQD--DSVF---VNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTE 652
            |    ::.:...:.:.|::  |.|.   .:.:.:..|:..:|:|  .||..|..|      .|..
  Fly   624 LSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSP--MLSCQTTPP------QDES 680

Human   653 PQKSQQSSGRTSGS---DDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFI 714
            ..|..|..|:.:.|   .||...|   ..:.|.||.:.|.|..||...|...:
  Fly   681 LDKGSQPGGKENSSITTIDPQAAS---EERQQRLLEQARRLILETRVKSGGSI------------ 730

Human   715 CEETDEQKLQ-TLD-IGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKK 777
             |.....||: |:. |.:..|:...|:::.||.: :|.||..:.|   ..|:..|::..::....
  Fly   731 -ESPTRPKLERTISPIHNGAEEFYAEHAKKLELK-EPGSPSHRLS---DPKVLQSFNAIVERVSP 790

Human   778 KHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHN- 841
            ||        :...|:  |::.|...:.::.    .||.:.::|..|..:.|   |:..||..|
  Fly   791 KH--------EKRGDK--LSYIDSELEALER----EQEAIDQKASNLEAKLR---AVMGGNPSNN 838

Human   842 ----TNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSG---VKMSELPSYGEM----AAEK 895
                ...:.||.                     :||..:..|   :::..|.|..|.    .|..
  Fly   839 RRGGARNSNPFL---------------------RLIRNSIGGGDVIRIKLLDSDDESLFGGGAGS 882

Human   896 LKERSKASGDENDNIEIDTNEEIPEGFVVGGGDEL-TNLENDLDTPEQNSKLVDLKLKKLLEVQP 959
            ...||.|..:::|.   ||:.:    .|...|||| |.|.   ..|..:|..|:...:..:
  Fly   883 GGGRSGACSEDDDR---DTSSD----SVCNSGDELHTRLR---PRPRSHSCFVNKNHQSTI---- 933

Human   960 QVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYI 1024
               |:|:                    .||...:....     |.....||:  .:.|.|.....
  Fly   934 ---NTPA--------------------HLRPHHVHHVV-----PYTHMLDSS--PSALSSQQSSC 968

Human  1025 ENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQID 1089
            :|.|...                          .:||||       :....|..|:|..:|.:..
  Fly   969 DNLPACS--------------------------DDDEVL-------AVAANGRAASLRRQQDRHR 1000

Human  1090 TRAALVEKRLRYLMDTGRN--TEE-EEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYEL 1151
            .|....|:| .:|..|..:  ||| ||.::.:||.||||||||:||..||::||:|.||||:|.:
  Fly  1001 RRRQRRERR-SHLCHTPNHCETEETEEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLERKYTM 1064

Human  1152 LNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQ 1216
            ||:||||..::|||:|||.|:.:|:|||:||:.:|:|||.||:.|..|| .|.|:|:.:.|.||.
  Fly  1065 LNQELRAAQSVEDWRKTEVQREKERLLLEELMTIVDKRDQLVQHLHNQE-IAIEDDQEIARKLEH 1128

Human  1217 NKGKMAKKEEKCVLQ 1231
              ..::.:::|||||
  Fly  1129 --VDISAEKDKCVLQ 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EHBP1	NP_001341141.1	NT-C2	12..165	CDD:313563	82/152 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..318		15/69 (22%)
		NPF	<274..383	CDD:318744	28/133 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..440		22/90 (24%)
		CH	447..549	CDD:306753	60/101 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..675		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..764		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..800		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..865		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..941		13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..996		4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1065		6/39 (15%)
		DUF3585	1074..1210	CDD:314926	67/138 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1198..1231		11/32 (34%)
		CAAX motif. /evidence=ECO:0000305\|PubMed:27552051	1228..1231		2/2 (100%)
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345	82/152 (54%)
		CH	460..562	CDD:237981	58/101 (57%)
		DUF3585	<1027..1122	CDD:288945	53/95 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149192
Domainoid	1	1.000	180	1.000	Domainoid score	I3512
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1256
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45597
OrthoDB	1	1.010	-	-		D165311at2759
OrthoFinder	1	1.000	-	-		FOG0002603
OrthoInspector	1	1.000	-	-		oto88791
orthoMCL	1	0.900	-	-		OOG6_105456
Panther	1	1.100	-	-	LDO	PTHR23167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3165
SonicParanoid	1	1.000	-	-		X2427
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800