DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EHBP1 and Actn

DIOPT Version :9

Sequence 1:	NP_001341141.1	Gene:	EHBP1 / 23301	HGNCID:	29144	Length:	1231	Species:	Homo sapiens
Sequence 2:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	178/832 - (21%)
Similarity:	321/832 - (38%)	Gaps:	226/832 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   445 ASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYD 509
            |.:.||:||:..|..|:.|.:.||..|:::||:|||::|..|||||||..|:..:..||...|:|
  Fly   149 AKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFD 213

Human   510 -GFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSG--QELNVVQIEENSSKSTYKVGNY 571
             ....:.|.|:|:|.|::....||:..:|||:......|.|  |..||..:.|.:.:.||...||
  Fly   214 VAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNY 278

Human   572 ETDTNSS-------VDQE-----KFYAELSDLKREPELQQPISGAVDFLSQ---DDSVFVNDSGV 621
            ..:|.::       |:||     :.|..|:.     :|.:.|...:.:|:.   |:|:    :||
  Fly   279 NAETAANRICKVLKVNQENERLMEEYERLAS-----DLLEWIRRTMPWLNSRQADNSL----AGV 334

Human   622 GESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGK 686
            .:...|::|            |.|:.|.....||::             :.:|.::.|.::.|..
  Fly   335 QKKLEEYRT------------YRRKHKPPRVEQKAK-------------LETNFNTLQTKLRLSN 374

Human   687 K-RLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLEN-SRSLECRSDP 749
            : ..|..|...:||  :|:..|.:.   :.|:..|:.|    :...:..|:||: ::..:.::|.
  Fly   375 RPAYLPTEGKTVSD--ISNSWKGLE---LAEKAFEEWL----LAETMRLERLEHLAQKFKHKADA 430

Human   750 ESPIK--KTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLS 812
            .....  |..:..:.........:|...||||.:.   |||                     |.:
  Fly   431 HEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAF---ESD---------------------LAA 471

Human   813 RQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEAR 877
            .|:.:::.|.:..|       |.....|:..:....|.| :.||.|  |...|.:|.|..:.||
  Fly   472 HQDRVEQIAAIAQE-------LNTLEYHDCVSVNARCQR-ICDQWD--RLGALTQRRRTALDEA- 525

Human   878 SGVKMSELPSYGEMAAEKLK----ERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLD 938
                        |...||:.    |.:|.:...|:.:: .|.|::.:.|:|...:|:..|....|
  Fly   526 ------------ERILEKIDILHLEFAKRAAPFNNWLD-GTREDLVDMFIVHTMEEIQGLIQAHD 577

Human   939 ----TPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTER 999
                |..:..|..:|.:..:.||:..|               .:..:..|.|
  Fly   578 QFKATLGEADKEFNLIVNLVREVESIV---------------KQHQIPGGLE------------- 614

Human  1000 FRNP--VVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEV 1062
              ||  .:.:.|.|.:.:.:              ||...|.|....||        .||...:|:
  Fly   615 --NPYTTLTANDMTRKWSDV--------------RQLVPQRDQTLANE--------LRKQQNNEM 655

Human  1063 LNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKN 1127
            |.:.|.:.:. :||...     ::|:|...|:.       |....:.|::...::|:      :.
  Fly   656 LRRQFAEKAN-IVGPWI-----ERQMDAVTAIG-------MGLQGSLEDQLHRLKEY------EQ 701

Human  1128 ALIRRMNQLSLLEKEHD-------LERRYELLNRE-LRAMLAIEDWQKTEAQKRREQLLLDELVA 1184
            |:......:..|||.|.       .|.||.....| ||.     .|::          ||..:..
  Fly   702 AVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRV-----GWEQ----------LLTSINR 751

Human  1185 LVNKRDALVRDLDAQEKQAEEEDE------HLERTLEQNKGKMAKKEEKCVL 1230
            .:|:.:..:...|::....|:.:|      |.::   ...|:::.:|.|..|
  Fly   752 NINEVENQILTRDSKGISQEQLNEFRSSFNHFDK---NRTGRLSPEEFKSCL 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EHBP1	NP_001341141.1	NT-C2	12..165	CDD:313563
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..318
		NPF	<274..383	CDD:318744
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..440
		CH	447..549	CDD:306753	39/102 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..675		9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..764		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..800		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..865		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..941		12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..996		3/35 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1065		10/39 (26%)
		DUF3585	1074..1210	CDD:314926	26/149 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1198..1231		7/39 (18%)
		CAAX motif. /evidence=ECO:0000305\|PubMed:27552051	1228..1231		1/3 (33%)
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063
		CH_ACTN_rpt2	139..252	CDD:409065	39/102 (38%)
		SPEC	302..525	CDD:238103	56/299 (19%)
		SPEC	420..647	CDD:238103	58/326 (18%)
		SPEC	538..760	CDD:238103	56/308 (18%)
		EFh	775..842	CDD:238008	6/29 (21%)
		EFhand_Ca_insen	847..913	CDD:400872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810