DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MGRN1 and CG9941

DIOPT Version :9

Sequence 1:	NP_056061.1	Gene:	MGRN1 / 23295	HGNCID:	20254	Length:	576	Species:	Homo sapiens
Sequence 2:	NP_572915.1	Gene:	CG9941 / 32330	FlyBaseID:	FBgn0030514	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	252/690 - (36%)
Similarity:	335/690 - (48%)	Gaps:	176/690 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGS 65
            ||:.:||:.|.||:.|...|:||:|||:.||:|.:||.||||:||||.||.||||||.||||||:
  Fly     1 MGNFVSRQNAAVEEADPSTNNAYKYPPRMGNFFGTHFIMGGERFDTPQPESYLFGENADLNFLGN 65

Human    66 RPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRY-------------------------KDDAD 105
            ||..|||..|..:||.|||:|||||||:|:|.|:.                         |:.::
  Fly    66 RPTAFPYPPPQANEPTKTLKSLVNIRKESVRFVKTMNDKKLGGVLEKPKMKEIDRDLDLDKEKSN 130

Human   106 SPTEDGD-------------------KPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSP 151
            ...||.|                   .|...|::|||||:||:.|||||...||:.........|
  Fly   131 VTIEDVDGNVLCSMGLGGGDADMTPPPPPCSYNIEFTFDSDAKCAITIYYFCSEDVSPSGVTLVP 195

Human   152 KSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGH 216
            :. .|.|||.||::|::|.||.||...:..:..:|||.:...|..:||.|..||:||.  :....
  Fly   196 RE-GLTSETYHYEKGINQCFSQPSHVFNPQQMPEDELGYSPGREQYPVAIHCVVEEGS--DECRQ 257

Human   217 AHVLLAAFEKHMD-GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVV 280
            :|..:...:.|.: ||:.::.||||..||.:.||||||||||||...:|. .|:|..|:.:|||:
  Fly   258 SHTTICVIDHHPENGSYVLRALKQKIFVDGLCYLLQEIYGIENKAVNKTS-LDEEIDDHGSECVI 321

Human   281 CLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVL 345
            |:|:.||||||||||||||.||||:||||||||||||.|||||||||||:|   .:|    :.||
  Fly   322 CMSETRDTLILPCRHLCLCNSCADSLRYQANNCPICRAPFRALLQIRAVQK---GIS----THVL 379

Human   346 AQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPL 410
            .|:.               |.|.|.     |.....|||||.|:||:|||||          .|.
  Fly   380 HQNT---------------PTSAAG-----EPAPVDVPPGYIPVSLIEALNG----------PPQ 414

Human   411 Y--------EEITYSGISDGLS-QASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPS------- 459
            |        .::|.|..:...| ..|..:.|...|..||::  ||:.|...||..|.|
  Fly   415 YVARARNSEHDVTDSAATVAASTMTSADIKATSPIKSSSQR--RPKIKKNASTCTSTSEVGTITN 477

Human   460 -------SPIH----EEDEEKLSEDVDAPPPLGGAELALRESSSPE------SFITE-------- 499
                   |..|    |.|.:|.|......|.||.       |:|||      ..:.|
  Fly   478 QSGGGNGSSTHSVEIESDPKKSSTATCTSPTLGA-------STSPEPKQDKLQIVNERKYPRSTA 535

Human   500 ------------EVDESS-------SPQQGTRAASIENVLQ-------DSSPEH---CGRGPPAD 535
                        :||..:       ||...::..|.:::.|       |...::   .|.||..:
  Fly   536 GSGGDGSAGTDDDVDSENEKLSPLLSPGSKSKNVSSKSLKQVVACLEADDDVDNKSSTGDGPTEE 600

Human   536 IYLPGRPTSMETAHGLATTSPTWPPL---GGPSPDPSAAE 572
                   :|::....:..|.|. |.|   |.|||..:.||
  Fly   601 -------SSLKKGSSIKRTKPR-PELSGSGAPSPAEATAE 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MGRN1	NP_056061.1	PHA02929	<232..331	CDD:331986	68/98 (69%)
		mRING-HC-C3HC5_MGRN1_like---blasttree	277..317	CDD:319703	33/39 (85%)
		modified RING-HC finger (C3HC5-type)	278..316	CDD:319703	31/37 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..384		5/28 (18%)
		Required for TSG101-binding	406..409		0/2 (0%)
CG9941	NP_572915.1	zf-C3HC4_3	318..360	CDD:290631	35/41 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145989
Domainoid	1	1.000	249	1.000	Domainoid score	I2129
eggNOG	1	0.900	-	-		E1_KOG4265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I2016
Isobase	1	0.950	-	0	Normalized mean entropy	S4888
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172099at33208
OrthoFinder	1	1.000	-	-		FOG0001616
OrthoInspector	1	1.000	-	-		otm41176
orthoMCL	1	0.900	-	-		OOG6_102038
Panther	1	1.100	-	-	O	PTHR22996
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5735
SonicParanoid	1	1.000	-	-		X1025
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740