Protein Alignment SMG6 and Smg6

DIOPT Version :10

• Sequence 1: NP_060045.4
• Gene: SMG6 / 23293
• HGNCID: 17809
• Length: 1419
• Species: Homo sapiens
• Sequence 2: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Alignment Length: 1130
• Identity: 267/1130 - (23%)
• Similarity: 451/1130 - (39%)
• Gaps: 287/1130 - (25%)

Human   349 TLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLS--SGGKGSEKQESKNP------KQELRGRG 405
            |.....:.|......|:..:|    :..:|.:.||  |.|.|....:||.|      |....|..
  Fly    39 TTTKALETENAENAEPVATTA----NASRPVEILSNASTGGGKPDAQSKQPVLDTSGKMAWEGGI 99

Human   406 RGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQ 470
            .|||.:.......||..|..:          |....|:.:..||   |:  |..:..|.|..:|:
  Fly   100 PGILRVTTSVAGDVNRNGQGQ----------GKNKSGNSARRRG---RK--DKEHATQSPVTRTR 149

Human   471 TPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPT 535
            ....|          ..|                                    :.||.
  Fly   150 LTTEH----------PDW------------------------------------FEPLL------ 162

Human   536 NGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS 600
                      |.|                       |.:|:  ..|:..|.|.:.:.|.|.|
  Fly   163 ----------GLP-----------------------HAKNI--VHLYDQLMVLNQRNLILIN--- 189

Human   601 RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVE 665
                    .:....:..:|...:::.:|..::|.....||...||..||.|    |..:|.   :
  Fly   190 --------WKNFCYIHDQLQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNV----RNYLKR---Q 239

Human   666 NPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMI 730
            ..:|.....|.|:::...|:..|..||...            .:.|......:|   :.|||.:|
  Fly   240 QTDQAHTHTLLLIEQAIKFYRMLYDKLMAK------------CVASSRCDSALK---VVAQRLLI 289

Human   731 CQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAA 795
            |.||:.|||.......:|.:|..:|.:||.:.|.||.|:||||::::|..::.||||||:|||..
  Fly   290 CLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLT 354

Human   796 SNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPS 860
            ||.|.:|||||:.||:|.:||.|:.|.||      ||..:..|.|:.    .....|.|:||:|.
  Fly   355 SNSIQSAKESLLDLFDEIRRKYEETEMKQ------SPMHYAAGSKNQ----KSKQMRKEVWIYPD 409

Human   861 -----HPRSSQGTES--GKDSEQE-NGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAE 917
                 |....:|.::  .|.:..| |....:.|.::..|.:..:|:..|||:|...:::...:..
  Fly   410 GIRRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLR 474

Human   918 KVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLL 982
            |:..:..|.|:|. :.:..:::|:::.:|:|.|.:::.|     ..|..::..:.....:.|.|:
  Fly   475 KLQIQIGVALRHE-NLLSRSKLLKIVALNLFVVEHNKPK-----TSRREMRYHSFNFANSFFGLM 533

Human   983 VRRCTCLL----KESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPP 1043
            :::...||    ::|...|....||            ...:...|..|.|:..|:....|.|.|.
  Fly   534 MKKTNQLLAGFVEDSTNVQCLPEED------------FATVNTYLQFVNVYVRWLSISLDVWEPV 586

Human  1044 PTSLDLPSHVAVDVWSTLA---DFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLA 1105
            .:.    .|..:|.|:.|.   ::...|...::.|    |:.      ::|:||..|.||.||..
  Fly   587 RSE----EHSFIDCWAELTILFEYIECLMGKHKLE----KNE------ILLDEDVALRGFTPLGR 637

Human  1106 APQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQ 1170
            ......|:::.|:::  ...:||..:..|.|.....:|.|          ..|:..:
  Fly   638 ETLSMDYLKRGSERL--QFFERVRRIGQFQEYYVQHQEAL----------QQPLESS-------- 682

Human  1171 EGTRLEDEEEDVVIEDFEEDSEAEGSG--------------------GEDDIRELRAKKLALARK 1215
                ...|..:..:::..|:.:||..|                    .:.|:.||...|..|..|
  Fly   683 ----FTVEHLNAAMKNALENYDAESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAK 743

Human  1216 IAEQQRRQEKIQAVLE--DHSQMRQMELEIRPLFLVPDTNGFIDHLASLARL-LESRKYILVVPL 1277
            ...:|....|::.:|:  |    .::.:|:||.:|:||||.|||.|....:| .|.::|.|::||
  Fly   744 ARVKQICTSKLEDILKFVD----TKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPL 804

Human  1278 IVINELDGLAKGQETD-HRAGGYAR------VVQEKARKSIEFLEQRFESRDSCLRALTSRGNEL 1335
            .|:.|||||:||.:.| :|:....:      .|..:|:||:||:    :|....::..|::|:.:
  Fly   805 TVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFI----KSAKGNVKCATTKGSFV 865

Human  1336 ESIAFRSEDITGQLGNNDDLILSCCL--------HYCKDKAKDFMPASKEEPIRLLREVVLLTDD 1392
            .:..|..  :..:..:|||.||:..:        ..|.| .|.|:..          |:||:|.|
  Fly   866 NASVFAL--VEEEYLSNDDKILATAMAVSKTAKTEQCTD-GKCFIQT----------ELVLITTD 917

Human  1393 RNLRVKALTRNVPVRDIPAFLTWAQ 1417
            ||||||||:||:.|..:..||.||:
  Fly   918 RNLRVKALSRNLAVSALDEFLQWAK 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMG6	NP_060045.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..79
		EJC-binding motif 1, mediates interaction with the EJC	39..59
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	99..165
		Interaction with telomeric DNA	114..503		32/161 (20%)
		EJC-binding motif 2, mediates interaction with the EJC	133..153
		PRK12678	147..>338	CDD:237171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	177..405		15/63 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..472		12/52 (23%)
		EST1	638..743	CDD:463062	28/104 (27%)
		EST1_DNA_bind	751..1103	CDD:431239	98/366 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..883		9/36 (25%)
		PIN_Smg6-like	1241..1416	CDD:350233	65/190 (34%)
Smg6	NP_651321.1	EST1	219..298	CDD:463062	26/100 (26%)
		EST1_DNA_bind	310..639	CDD:431239	100/370 (27%)
		PIN_Smg6-like	767..941	CDD:350233	65/190 (34%)