Protein Alignment SMG6 and Smg5

DIOPT Version :10

• Sequence 1: NP_060045.4
• Gene: SMG6 / 23293
• HGNCID: 17809
• Length: 1419
• Species: Homo sapiens
• Sequence 2: NP_609685.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Alignment Length: 1221
• Identity: 214/1221 - (17%)
• Similarity: 380/1221 - (31%)
• Gaps: 479/1221 - (39%)

Human   579 QELHRLLRVADNQ-ELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQI 642
            ::|:|.|..|..| :....|:.|..::....:|   :.|:.|:||.::.|..|.: |..:.|.::
  Fly    43 KDLYRSLYTASKQLDDAKRNVQSVGQLFQHEIE---EKRSLLVQLCKQIIFKDYQ-SVGKKVREV 103

Human   643 LWKNAFYQVI----EKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDY 703
            :|:..:|:.|    :.:.:..:|  ....::...:|...|..|...:..|..:::..|...|:..
  Fly   104 MWRRGYYEFIAFVKKNWHKQCQD--AATAQENMQKLERFLCAGIFNYKRLSARMEEIYDLDLKYL 166

Human   704 MD----------------------GLAIRSKPLRKTVKYALISAQRCMICQGDIARY----REQA 742
            :|                      |.....|.| :.|.:||.:....::..||:.||    |..:
  Fly   167 IDFSIISDGYISDMIGDTMESSHSGTHAVDKSL-EAVSFALDTIHSSLLSLGDLHRYFLDFRIDS 230

Human   743 SDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLM 807
            ..:.:..:...:||:|..:.|..|...|||..|.......||:.|:|:.||....|...::.:|.
  Fly   231 KLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENNLN 295

Human   808 SLFEETKRKAEQMEKKQHEEFDLS---------------------PD------------------ 833
            .||   .:..|.:|:...|:.|.:                     ||
  Fly   296 KLF---AKHTEYLERMDPEKLDFNIEDFFARFYLIVDIFFFDKEVPDFNALCHCVLIDLRKILCS 357

Human   834 -QWRKGKKSTFRHVG---DDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSL------SPSDL 888
             |.|..:.|.|:.|.   ...::|::...|.                   :.||      :.|||
  Fly   358 QQLRVPEPSIFKIVSILFFCLSKLKMINSPK-------------------VYSLHAFLVAACSDL 403

Human   889 NKRFILSFLHAHGKLFTRI-GMETFPAVAEKVLKEFQVLLQHSP-------SPIG--STRMLQLM 943
            ....|:|.   ...:..|. ..|.|.|..|:..:||..:::.|.       :.:|  ..:..:||
  Fly   404 MDACIVSI---EQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKNWLAAVGECERKDKKLM 465

Human   944 TINMFAVHNSQLKDCFS---------EECRSVIQEQAAALGLAMFS------------------- 980
            .      ....||||.|         ||.::........:|.|:.:
  Fly   466 P------RPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKS 524

Human   981 ----LLVRR----------CTCLLKESA-----------KAQLSSPEDQD--------------- 1005
                :.:||          .:|...||.           ...|||..|.|
  Fly   525 KRRGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGE 589

Human  1006 -----------------------------DQDDIKV---------------SSFVPDLKELLPSV 1026
                                         |.:|:.:               :|...|.:|||.|.
  Fly   590 ERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSF 654

Human  1027 KVWSDWMLGYPDTWN----PPPTSLDLP--------------SHVAVDV---------------W 1058
            :|.........|..:    |||.|...|              .::.:|.               |
  Fly   655 EVLQLNFKSAEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINPNIVIDCLHNEPTIRALKMLFDW 719

Human  1059 ----------------------STLADFCNI-------------LTAVN-----------QSEVP 1077
                                  ..|.::|||             ||..|           ::.||
  Fly   720 LRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVELFDVRANVP 784

Human  1078 LYKD---PDDDL---TLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLE 1136
            |.:|   .:.|:   |.:.|:.:.::...|    .||:...:             |:..:..|..
  Fly   785 LTEDFAFKNFDIFQSTQITLDWETIIRERV----TPQEESIL-------------RIFKMVDFGF 832

Human  1137 ALCGQEEPLLAF-------------------KGG----KYVSVAPVPDTMGKEMGSQEGTRLEDE 1178
            .:|.|::....|                   |||    :....||..:...:..|...  |..|.
  Fly   833 FICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAPKTNRTKRNEGRTR--RYSDR 895

Human  1179 EEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVL------------- 1230
            :..:|.:.:..:.|      :|.:.|.|    .:.||...:.|..||..||:
  Fly   896 KNGIVRKSYTSNEE------KDTVEECR----KMPRKGYLRNRNAEKAAAVITSATGTSVAGGTS 950

Human  1231 ---------------------EDHSQMRQ-----------------MELEIRPL--------FLV 1249
                                 |:.|:.:.                 :|.|:|..        |:|
  Fly   951 ASTTTNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAHVVMSPFVV 1015

Human  1250 PDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFL 1314
            .|:....::...:..|:.::|.|:::|..|:||||.|.|.              .|..|..|.:|
  Fly  1016 VDSKALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKR--------------SENVRHVIRWL 1066

Human  1315 EQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEP 1379
            ||.|:..:..|||  .|.||.:.::...  |:.::..:..:.|... .:|     :.:.|:..:|
  Fly  1067 EQEFKQGNRHLRA--QRDNESQPLSLLK--ISRKMDRDASVFLQIA-QFC-----NHLVANHADP 1121

Human  1380 --IRLLREVVLLTDDRNLRVK----------ALTRNVPVRDIPAFLTWAQV 1418
              ..|.:.||......||..|          .:..::|||       :||:
  Fly  1122 HVSELQKSVVTYLSGDNLHEKNRQQQNFSYTGILDSIPVR-------YAQI 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMG6	NP_060045.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..79
		EJC-binding motif 1, mediates interaction with the EJC	39..59
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	99..165
		Interaction with telomeric DNA	114..503
		EJC-binding motif 2, mediates interaction with the EJC	133..153
		PRK12678	147..>338	CDD:237171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	177..405
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..472
		EST1	638..743	CDD:463062	23/134 (17%)
		EST1_DNA_bind	751..1103	CDD:431239	101/607 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..883		1/28 (4%)
		PIN_Smg6-like	1241..1416	CDD:350233	43/194 (22%)
Smg5	NP_609685.1	EST1	99..227	CDD:463062	22/130 (17%)
		EST1_DNA_bind	240..479	CDD:431239	55/269 (20%)
		MSCRAMM_ClfA	<470..>580	CDD:468110	19/109 (17%)
		PIN_Smg5-like	1012..1173	CDD:350232	43/185 (23%)