DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXW11 and btrc

DIOPT Version :9

Sequence 1:	NP_001365903.1	Gene:	FBXW11 / 23291	HGNCID:	13607	Length:	563	Species:	Homo sapiens
Sequence 2:	XP_012822030.1	Gene:	btrc / 549140	XenbaseID:	XB-GENE-486122	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	468/590 - (79%)
Similarity:	505/590 - (85%)	Gaps:	43/590 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    16 CSVPRSLWLGCANLVESMCALSCLQSMPSVRCL---QNTSVMEDQNEDESPK-----KNTLWQ-- 70
            |.||:||||||::||:||.:|.||.: |....|   |..|..||.|.||.|:     ||||.|
Frog    22 CPVPKSLWLGCSSLVDSMPSLQCLYN-PGTGALTTFQTASEREDCNRDEPPRKIIPEKNTLRQTS 85

Human    71 ------------------------------ISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWS 105
                                          ::|||||:||.::|....||:|||:||:|||:|||
Frog    86 NNCASLCITQDTVCLSGSAMKTESCVVKTKLANGTSSMIVPKQRKLSANYEKEKELCVKYFEQWS 150

Human   106 ESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAEL 170
            |.||||||||||||||||||||||:|||||||||||||||.:|||||||||||||||||||:|||
Frog   151 ECDQVEFVEHLISRMCHYQHGHINTYLKPMLQRDFITALPARGLDHIAENILSYLDARSLCSAEL 215

Human   171 VCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKI 233
            |||||.||.|:|||||||||||||||.||:||:|||||.||||||:|.||  |||||||:|||||
Frog   216 VCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGKTPPNSFYRALYPKI 280

Human   234 IQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT 298
            ||||||||||||||||:||||.||||.|||||||||||:||:||||||:||||||.:|||.:||.
Frog   281 IQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRVLM 345

Human   299 GHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI 363
            ||||||||||||||||:|||||||||||||||||:|||||||.||||||||:||:||||||||||
Frog   346 GHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSI 410

Human   364 AVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 428
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Frog   411 AVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 475

Human   429 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 493
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Frog   476 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVA 540

Human   494 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTY 558
            ||||||||.||||||||||||||||||||||||:|||||||||||||||.|.:....||||||||
Frog   541 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAESTRSPSRTY 605

Human   559 TYISR 563
            |||||
Frog   606 TYISR 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXW11	NP_001365903.1	Beta-TrCP_D	99..137	CDD:403372	34/37 (92%)
		F-box-like	141..188	CDD:403981	40/46 (87%)
		WD40	261..539	CDD:238121	260/277 (94%)
		WD40 repeat	264..299	CDD:293791	27/34 (79%)
		WD40 repeat	305..339	CDD:293791	31/33 (94%)
		WD40 repeat	344..381	CDD:293791	34/36 (94%)
		WD40 repeat	388..421	CDD:293791	31/32 (97%)
		WD40 repeat	427..461	CDD:293791	33/33 (100%)
		WD40 repeat	467..510	CDD:293791	40/42 (95%)
		WD40 repeat	516..538	CDD:293791	20/21 (95%)
btrc	XP_012822030.1	Beta-TrCP_D	144..182	CDD:288940	34/37 (92%)
		F-box-like	186..233	CDD:289689	40/46 (87%)
		WD40	<295..591	CDD:225201	275/295 (93%)
		WD40	308..586	CDD:238121	260/277 (94%)
		WD40 repeat	311..346	CDD:293791	27/34 (79%)
		WD40 repeat	352..386	CDD:293791	31/33 (94%)
		WD40 repeat	391..428	CDD:293791	34/36 (94%)
		WD40 repeat	435..468	CDD:293791	31/32 (97%)
		WD40 repeat	474..508	CDD:293791	33/33 (100%)
		WD40 repeat	514..557	CDD:293791	40/42 (95%)
		WD40 repeat	563..585	CDD:293791	20/21 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I32960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118286at7742
OrthoFinder	1	1.000	-	-		FOG0002886
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	1	1.000	-	-		X2712
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040