Protein Alignment FBXW11 and btrc

DIOPT Version :10

• Sequence 1: NP_001365903.1
• Gene: FBXW11 / 23291
• HGNCID: 13607
• Length: 563
• Species: Homo sapiens
• Sequence 2: XP_012822030.1
• Gene: btrc / 549140
• XenbaseID: XB-GENE-486122
• Length: 610
• Species: Xenopus tropicalis
• Alignment Length: 590
• Identity: 468/590 - (79%)
• Similarity: 505/590 - (85%)
• Gaps: 43/590 - (7%)

Human    16 CSVPRSLWLGCANLVESMCALSCLQSMPSVRCL---QNTSVMEDQNEDESPK-----KNTLWQ-- 70
            |.||:||||||::||:||.:|.||.: |....|   |..|..||.|.||.|:     ||||.|
 Frog    22 CPVPKSLWLGCSSLVDSMPSLQCLYN-PGTGALTTFQTASEREDCNRDEPPRKIIPEKNTLRQTS 85

Human    71 ------------------------------ISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWS 105
                                          ::|||||:||.::|....||:|||:||:|||:|||
 Frog    86 NNCASLCITQDTVCLSGSAMKTESCVVKTKLANGTSSMIVPKQRKLSANYEKEKELCVKYFEQWS 150

Human   106 ESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAEL 170
            |.||||||||||||||||||||||:|||||||||||||||.:|||||||||||||||||||:|||
 Frog   151 ECDQVEFVEHLISRMCHYQHGHINTYLKPMLQRDFITALPARGLDHIAENILSYLDARSLCSAEL 215

Human   171 VCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKI 233
            |||||.||.|:|||||||||||||||.||:||:|||||.||||||:|.||  |||||||:|||||
 Frog   216 VCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGKTPPNSFYRALYPKI 280

Human   234 IQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLT 298
            ||||||||||||||||:||||.||||.|||||||||||:||:||||||:||||||.:|||.:||.
 Frog   281 IQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRVLM 345

Human   299 GHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI 363
            ||||||||||||||||:|||||||||||||||||:|||||||.||||||||:||:||||||||||
 Frog   346 GHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSI 410

Human   364 AVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 428
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
 Frog   411 AVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 475

Human   429 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 493
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
 Frog   476 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVA 540

Human   494 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTY 558
            ||||||||.||||||||||||||||||||||||:|||||||||||||||.|.:....||||||||
 Frog   541 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAESTRSPSRTY 605

Human   559 TYISR 563
            |||||
 Frog   606 TYISR 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW11	NP_001365903.1	Beta-TrCP_D	99..137	CDD:463465	34/37 (92%)
		F-box_FBXW1B	137..187	CDD:438954	43/49 (88%)
		WD40 repeat	264..299	CDD:293791	27/34 (79%)
		WD40	<270..539	CDD:441893	251/268 (94%)
		WD40 repeat	305..339	CDD:293791	31/33 (94%)
		WD40 repeat	344..381	CDD:293791	34/36 (94%)
		WD40 repeat	388..421	CDD:293791	31/32 (97%)
		WD40 repeat	427..461	CDD:293791	33/33 (100%)
		WD40 repeat	467..510	CDD:293791	40/42 (95%)
		WD40 repeat	516..538	CDD:293791	20/21 (95%)
btrc	XP_012822030.1	Beta-TrCP_D	144..182	CDD:463465	34/37 (92%)
		F-box_FBXW1A	180..239	CDD:438953	52/58 (90%)
		WD40	308..586	CDD:238121	260/277 (94%)
		WD40 repeat	311..346	CDD:293791	27/34 (79%)
		WD40 repeat	352..386	CDD:293791	31/33 (94%)
		WD40 repeat	391..428	CDD:293791	34/36 (94%)
		WD40 repeat	435..468	CDD:293791	31/32 (97%)
		WD40 repeat	474..508	CDD:293791	33/33 (100%)
		WD40 repeat	514..557	CDD:293791	40/42 (95%)
		WD40 repeat	563..585	CDD:293791	20/21 (95%)