Protein Alignment WWC1 and HUL5

DIOPT Version :9

• Sequence 1: XP_011532787.1
• Gene: WWC1 / 23286
• HGNCID: 29435
• Length: 1185
• Species: Homo sapiens
• Sequence 2: NP_011374.1
• Gene: HUL5 / 852736
• SGDID: S000003109
• Length: 910
• Species: Saccharomyces cerevisiae
• Alignment Length: 723
• Identity: 136/723 - (18%)
• Similarity: 259/723 - (35%)
• Gaps: 175/723 - (24%)

Human   451 KALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSR-------- 507
            |.|.|:.|...:|....:..|:|::   |:...::...|:::...:     :.|||:
Yeast    24 KDLLEKAKRERERRAQDKLKEDASK---TIQKSIRRHFSNVRLFKN-----TFTSSQLVHMIPAY 80

Human   508 -GSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLE---GATGFRPSGCITTIHEDE-- 566
             |.|:               ||  ..|.|.:...|:....|.   .:.|.|....:..:::|:
Yeast    81 GGKLI---------------YY--ISQYDLQQLLKLSHNFLSSYPNSLGNRQLLSLLKLYQDDAL 128

Human   567 VAKTQKAEGGGRLQALRSLS----GTPKSMTSLSP---RSSLSSPSPPCSPLMADPLLAGDAFLN 624
            ||:|           |..|:    ...:.:.|||.   |:|..|.|  .:..:||.:.|.:...:
Yeast   129 VAET-----------LSDLNMDCPTVDEFLDSLSVYLCRASFLSYS--SASKLADVIEAWEVMHS 180

Human   625 SLEFEDPELSATLCELSLGNSAQERYRLEEPG--TEGKQLGQAVNTAQGCGLKVACVSAAVSDES 687
            |       .|.::..:|:|:..:..:.|:...  .|...|.|.:||..   :....::...|..|
Yeast   181 S-------ASISIFSISIGSYEKRPFALQFYCILAERNLLPQLINTNP---ILWDNMAKTYSHCS 235

Human   688 VAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSALLQQ 752
            ..|...:.:..:..        |::..:.:|..:.....||:.||    |.:...::..:..:..
Yeast   236 KGGQKNIAKLLIPN--------FNNHIAPSVLRSDNDYVLKFYEK----AFIDEVIATTANYVSD 288

Human   753 QDQKVNIR--VAVLP---CSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTT 812
            :|...|:.  :|..|   |..|...           ||:.|:.|...:|:...|.|   .:...|
Yeast   289 EDHVKNLMCYIASSPNQSCKNSVLI-----------TLLSNKDFVRRLSWEFFHTK---FNASKT 339

Human   813 DRSHLEECLGGAQISLAEVCRSGERSTRWYN-LLSYKYLKKQSRELKPVGVMAPASGPASTVSWD 876
            :...|...|  ||:....:..|.:|....|| ::..:.|||.:..||..         .....|:
Yeast   340 EAHPLFSVL--AQLIDMHLLISTDRELLDYNSVIPIEELKKFTSTLKDF---------TFRQYWE 393

Human   877 --QDAVSALLEQTAVELEKRQEGRS-----STQTLEDSWR-----------YEETSENEAVAEEE 923
              :...:.:|::....|.|..|..|     ||:.....|.           |||..|.|.:..|.
Yeast   394 LPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQEYEDLYREH 458

Human   924 EEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPSQGPFLRGS 988
            .||..:|:.|:::..:|..|.:......|:.|...:..          :.|::....:.||
Yeast   459 LEEESDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSSL----------RFRKLEILLELPF---- 509

Human   989 TIIRSKTFSPGPQS-----QYVC----RLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSPPPQ 1044
                   |.|..:.     .::.    ||: .|.|.:.::...|:....:.::|..:.|.:....
Yeast   510 -------FIPFEERVDLFYMFIALDKKRLS-LDDDHNLINMFTPWASTGMRKQSAIISRDNVLED 566

Human  1045 PSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE--LKEQLEQAKSHGEKELPQWL- 1106
            ..:..:...|| .:.|||:        |:.::..:|..:...  .||.|......|.|:....|
Yeast   567 AFNAFNSIGER-FKASLDV--------TFINEFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELF 622

Human  1107 REDERFRL 1114
            |.::|:.|
Yeast   623 RTNDRYEL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	429..>481	CDD:299846	8/29 (28%)
		C2_Kibra	721..844	CDD:176062	27/128 (21%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	132/712 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900