Protein Alignment WWC1 and kibra

DIOPT Version :9

• Sequence 1: XP_011532787.1
• Gene: WWC1 / 23286
• HGNCID: 29435
• Length: 1185
• Species: Homo sapiens
• Sequence 2: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1270
• Identity: 412/1270 - (32%)
• Similarity: 625/1270 - (49%)
• Gaps: 257/1270 - (20%)

Human     5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGD 69
            :.|||:||:.|:|||||.|||||.|:.|:|:||||.||||.||.||:.||||:||||:|||.:|.
  Fly    53 DFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGP 117

Human    70 YFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAV 134
            |:|:|..::||:||||.:|:..||.||.|||..||:.|..::|::.||||||..||:||..|
  Fly   118 YYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL--- 179

Human   135 WEHKL-GSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKI 198
               || .|:.||.|.|||.|::|||:|:|::..|:.||::||:|:.|:.:::.:.|||..||..:
  Fly   180 ---KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSV 241

Human   199 DKKMSDAQ-GSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSS 262
            .:|::..: |.|.:.|..|:..|...:.|::..|||.:::|::||..:|          ::|...
  Fly   242 GEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIK----------NELGRQ 296

Human   263 SSSLESSSFPLPKQYLDVSSQTDISGSFGINSNN--QLAEKVRLRLRYEEAKRRLSCQCGQATPS 325
            ..|.|:|....|...:.|:||||:.||.|.|.|.  :.||..:.:.:|.|.::.
  Fly   297 QISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKH----------- 350

Human   326 NSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTLNLGSVPSCRNACLRWIANLKIQLAKLDSEA 390
                                                              |..|:.|||......
  Fly   351 --------------------------------------------------IKKLQQQLADHVERI 365

Human   391 WPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTE 455
            .||.|:|::||::||.|||:||.::..||.:..::.|...:...|.:||:||:.|.:..:..:..
  Fly   366 EPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVAN 430

Human   456 RLKLNSKRNQLVRELEEATRQVATLHSQLKSLSS-SMQSLSSGSSPGSLTSSRGSLVASSLDSST 519
            ||:.:.::..|:.:|:||.:....|..:|||.|| |..|:|||||.|||         |:..|.:
  Fly   431 RLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STASSKS 486

Human   520 SASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRS 584
            :.||||:|.|||     .:.|.::.:.|.     |.|..:...|:.:           ||..:..
  Fly   487 ALSFTDIYIDPF-----AVDSPIDVVDLR-----RRSQRLFQQHQQQ-----------RLHPVHP 530

Human   585 -LSGTPKSMTSLSPRSSLSSPSPPCSPL------------------MADPLLAGDAF-------- 622
             |.....:..:||||||||..:||.||:                  .|:.|.|..|:
  Fly   531 VLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPI 595

Human   623 ---------LNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK---QLGQAVNTAQGCGLK 675
                     |:|...:...|.|.|.:|::|...........|.:|..   .|.|.:.:.......
  Fly   596 SGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSN 660

Human   676 VACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILI 740
            ...||||||:|||||||||:|||...|...|.|             ::||.|||   .||..:|:
  Fly   661 TRSVSAAVSNESVAGDSGVFEASRAHLPRKELA-------------QVQIGLKY---LKQEGVLV 709

Human   741 IQL---SNLSAL--LQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPAL 800
            :.|   :||.||  ....:.:|.:|.|:||.|.::   .||:.|......|||:.|.|.::...|
  Fly   710 VSLERANNLLALWTASADNSQVYLRAALLPNSLTS---IRTKALGDFQKPVFNDTFAVPITLDKL 771

Human   801 HQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERST-RWYNLLSYKYLKK-QSRELKPVGVM 863
            ..|:|:|.|.|. ....||.:|..|||:||.  :.|.|| :|||:||.|::.. :|.::......
  Fly   772 LTKSLQVTVVTM-TGQKEEIIGTVQISMAEF--NPEDSTLKWYNVLSSKFIPSFESLDIPSTSAA 833

Human   864 APA-------------------------SGPASTVSWDQDAVSALLEQTAVELEKRQEGRSSTQT 903
            |.|                         |...||::.:|.....|.||.|.||       .....
  Fly   834 AAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAEL-------LGLGP 891

Human   904 LEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGY-PALK---VDKETNTETPAP 964
            |.:    .|.|:::  .::||||:::::...||....:|..:..| ..:|   .||||||:
  Fly   892 LNE----PECSDDD--DDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTD---- 946

Human   965 SPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPG---PQSQYVCRLNRSDSDSSTLSKKPP--F 1024
              ....|:..|    .|...:....:.||:||:|.   .:::|.||||||||||:......|  |
  Fly   947 --RAYLPEKSR----GQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTF 1005

Human  1025 VRNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQ---LTQEISVLKE 1086
            .|.:.||||:|....:    |.||..|....:.||||||||||||.   ||:   |..:|:.|:.
  Fly  1006 QRGAAERRSLRFHSKA----PKSVTKLHHTHIPRTSLDLELDLQAQ---HSKLYFLNDQIAKLQN 1063

Human  1087 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRG 1151
            |||.|::|..:.:..:..|..|:|.|:.|:     .:.|.|:...|.|..|::...||::|:||
  Fly  1064 LKEVLQKACENKDPLVAAWAIENEEFQRLV-----ARADPAKCPEERQLQKLLMKTAKEIHKLR- 1122

Human  1152 QSCKEP---PEVQSFREKMAFFTRPRMNIPALSAD 1183
             ..|.|   |::.||:||:.||||..:::|.|.::
  Fly  1123 -KTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC1	XP_011532787.1	WW	9..39	CDD:238122	19/29 (66%)
		WW	55..84	CDD:278809	16/28 (57%)
		ALDH-SF	429..>481	CDD:299846	12/51 (24%)
		C2_Kibra	721..844	CDD:176062	46/128 (36%)
kibra	NP_001034055.1	WW	57..87	CDD:238122	19/29 (66%)
		WW	103..132	CDD:278809	16/28 (57%)
		C2_Kibra	693..813	CDD:176062	47/141 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156964
Domainoid	1	1.000	262	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1181
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	1	1.000	-	-		FOG0003726
OrthoInspector	1	1.000	-	-		otm41793
orthoMCL	1	0.900	-	-		OOG6_103792
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4620
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800