Protein Alignment WWC1 and ubr-5

DIOPT Version :9

• Sequence 1: XP_011532787.1
• Gene: WWC1 / 23286
• HGNCID: 29435
• Length: 1185
• Species: Homo sapiens
• Sequence 2: NP_492389.1
• Gene: ubr-5 / 172697
• WormBaseID: WBGene00009460
• Length: 2944
• Species: Caenorhabditis elegans
• Alignment Length: 1132
• Identity: 211/1132 - (18%)
• Similarity: 366/1132 - (32%)
• Gaps: 364/1132 - (32%)

Human    75 NTKTTQIEDPRVQWRREQEHMLKDYLVVAQ-EALSAQ----KEIY----------QVKQQRL--E 122
            |..|.|   |.::..|||..:....||.|. :.||..    ..:|          |:|.|||  :
 Worm  1963 NDNTDQ---PSLETAREQLALTFSVLVRAGCDILSRMPRPVMSVYTKADDNAKRSQLKAQRLFGD 2024

Human   123 LAQQEYQQLHAVWEHKLGS-------QVSLVSGSSSSSK----------YDPEILKAEIATAKSR 170
            :.|..::.:..|:|.....       :.|||..:|..|:          |...:|:.....||..
 Worm  2025 ILQDTFRWMGRVFESTEAKINFNETYEKSLVRPASPGSEDKRGRKDALHYIHSLLRLATDEAKDS 2089

Human   171 VNKLKREMVH---LQHELQFK------ERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKK 226
            :..:..||::   |..:..|.      ||..:..:.||         |..|..:...||
 Worm  2090 LAHVDIEMLYPVALVADAYFHFLSCNVERPIELKQLID---------YYEDSQRRHFRE------ 2139

Human   227 AITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPL-----------PKQYLDV 280
              .| |:...||:....|...........|...|.:.|.....|..|           ||....:
 Worm  2140 --KC-EQTDNDLMIGFFMRPVSLSWPGHLHDGAWDTLSGRHHISKTLKIEEECPMLGGPKMLTML 2201

Human   281 SSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRLSCQCGQATPSNSELTH--------YQLPQA 337
            :.|.|:           ..:.|     .:|.|||.|.......   .|.|:        |:.|..
 Worm  2202 TKQEDL-----------FRDPV-----IDETKRRTSSYLNDPV---EEYTYNLLDRPFEYRNPGV 2247

Human   338 SSKTARH-LYLDSHFLFSLKRTTLNLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDR 401
            |.....| |.|:..|: |:.|...:|...|.      ..:.:....:.|     :||.:....|.
 Worm  2248 SLAMVPHRLKLEREFI-SITRDFYHLDRTPD------HEVKDYSTAVGK-----FPGYIGRLDDS 2300

Human   402 LILINEKEELL-----KEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLN- 460
            :...  |:.||     :|..:.|  ||.               |.|.|..:.....:||.|..:
 Worm  2301 ISKF--KDNLLIHSCNRERLYFS--KWF---------------KTLNAIGNRFYDKMTEALGADV 2346

Human   461 SKRNQLV-----------RELEEATRQVATLHSQLKSL--------------------------S 488
            :..|.::           |...:||.:..|.||.:|.:                          .
 Worm  2347 AFENSIMLRRLASFETKQRLFNKATEKYRTQHSNVKEIVLDVRREPGSLFRDTMVQLHHLYAKRM 2411

Human   489 SSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGF 553
            .|::||.||.:|.:.|..|...:.   :.......|..:|..|          .|..:::.|. |
 Worm  2412 MSVRSLESGHAPLAGTRLRVHFID---EPGEGTGVTRSFYTAF----------AESCMMDVAP-F 2462

Human   554 RP------SGCITTI--------HEDEVAKT-QKAEGGGRLQALR------SLSGTPKSMTSLSP 597
            .|      |..|.::        |:.|:.|| :||.   |.||:|      .|...|.::.  :|
 Worm  2463 TPETVAEKSSLIQSVLHPNNEYEHDMEITKTLRKAR---REQAIRLRTHLQRLKTFPLNLA--AP 2522

Human   598 RSSL-----------------SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNS 645
            |..:                 |:.|.|.:|            ||..:.|     .||.::....|
 Worm  2523 RFDIKNFTGEGNWTKKVLQDSSAESQPVAP------------LNWGQHE-----GTLRKIHTMTS 2570

Human   646 AQERYRLEEPGTEGKQLG-----------QAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASV 699
            .    .|.:..|.|:.:|           :|||......|.:..:.|.:..|   |:...|....
 Worm  2571 G----FLTDEKTIGRVMGIMCQLPTEVFVKAVNNDDTMRLHIQQILAELRAE---GELDDYSRVF 2628

Human   700 QRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSN---------------LSAL 749
            :.|..:|....|.::...:..|...:...: ||.......:.::.|               :...
 Worm  2629 RGLQNAEQPRSDDEQWNVLVGTESPLDQLF-EKAPYGEFYVPKIGNGAPMRLAAYRTVGRIMGIC 2692

Human   750 LQQQD-------QKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRV 807
            |.|.|       :.:...:..||     .|..   .|...|.::||.:..:..::|:      .:
 Worm  2693 LSQGDIFPLRFSRHIFSYILKLP-----ICWL---DLGFYDPVLFNNLRALFKAHPS------EL 2743

Human   808 DVCTTDRSHLEECLGGAQIS-----------------LAEVCRSGERSTRWYNLLSYKYLKKQSR 855
            |   ||.|.:|:...|..::                 :..|.:..||......:::::.:::...
 Worm  2744 D---TDFSIVEQSADGKAVTVNLKPNGDEVLVNKDNVIEYVYKYAERVLVGKRIITFEAIREGIL 2805

Human   856 ELKPVGV---MAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSSTQTLE--DSWRYEETSE 915
            ::.|..:   :.|..........:..::|.|.|.|..    ..|.|:|.:||.  ..|.::..
 Worm  2806 DVIPESMLFGLTPEDLRLIICGIESVSISVLQENTGF----LDESRASQETLNRFKQWFWQVI-- 2864

Human   916 NEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPS 980
             |:..::|::|:        ||....||.:   ||.       .:.|..:..::||:
 Worm  2865 -ESFTQQEKQEL--------VFFWTGSPAL---PAA-------GKWPTSASVMLRPQ-------- 2902

Human   981 QGPFLRGSTIIRSKTFSPGPQSQYVCR 1007
            :..||..:....|:.:.|...|:.|.|
 Worm  2903 EDVFLPTANTCISRLYVPVYSSKRVLR 2929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809	3/8 (38%)
		ALDH-SF	429..>481	CDD:299846	11/63 (17%)
		C2_Kibra	721..844	CDD:176062	24/161 (15%)
ubr-5	NP_492389.1	E3_UbLigase_EDD	182..233	CDD:288409
		ZnF_UBR1	1202..1271	CDD:197698
		HECTc	2576..2942	CDD:238033	69/408 (17%)
		HECTc	2614..2941	CDD:214523	61/370 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900