DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp418 and Kr-h1

DIOPT Version :9

Sequence 1:	NP_666291.2	Gene:	Zfp418 / 232854	MGIID:	2444763	Length:	652	Species:	Mus musculus
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	144/518 - (27%)
Similarity:	205/518 - (39%)	Gaps:	101/518 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    90 TKKPHPSDICSTVLKDILHLSDLPGQKPHLTEVCTDLLDQKHHRAKN-WLKKD--VDSLVKNCIF 151
            ||...|..|.   :||:|..|.            |:|||.....||. .:||.  .||.....::
  Fly     8 TKSWAPKQIW---IKDVLKKSG------------TELLDISKSPAKAVAVKKSPAKDSATTKMVY 57

Mouse   152 HVA----------GNPSVCSKIGEKFPAVWNLLQPKAIPKGEKQNQIKCRKAFHSEKNNSKSDKY 206
            :.|          .....|.::.....|....:.....|.|.:|.        |.|...:...:.
  Fly    58 YSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQE--------HFELLQTPQQRQ 114

Mouse   207 NKSSSPQHRLHEYPRLCSGKEGFESNSCEQDLNKY--------SIAPS-QTDQTENRPYGCHDCG 262
            .:.........|..:..|.:...:.:..:|...::        :.||| |..:||  |.|
  Fly   115 MQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTE--PVG----- 172

Mouse   263 KWFGQKATLRIHQRRHTGEKP-YRCGECGKSFCQSSNLSEHCRVHSGER---------------- 310
             .|...|.:....|:.:..|| ::|.:||.:|...|..:.|.:.||..:
  Fly   173 -GFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPV 236

Mouse   311 ---PFECLECGKAFGCHSS--LLRHQRTHTGEWPYECGDCGRLFRQIVSLITHQRTHTTEKPYEC 370
               ..|..:.|...|...|  :........|..||:|..|.:.|.....||.|.||||.|:|:||
  Fly   237 STAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFEC 301

Mouse   371 GQCEKSFSHKATLTVHQRVHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYKCGECGLCFRQ 435
            ..|.|.||.|..|.||:|:||.|:||.|:.||::|..|..|.:|.:|||||:|:||..|...|.|
  Fly   302 EFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQ 366

Mouse   436 RATLMKHQRTHTSERPYECRECGKFFKQYFYLIEHSRIHTTTEFYECGQCGKSYTQNATLIRHQR 500
            ...|:.|.||||.|:||:|.|.|                          |||.:|.:..|..|.|
  Fly   367 SGQLVIHMRTHTGEKPYKCPEPG--------------------------CGKGFTCSKQLKVHSR 405

Mouse   501 VHTGESPYKCKECGKAFEYKSRLNRHQRTHTGERPYECAKCGKFFRESYNLAEHQKIHTKAKP 563
            .||||.||.|..|.:.|.|...|..|:..|.|.:.|:|..|.:.|:....:..|.|.|....|
  Fly   406 THTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp418	NP_666291.2	KRAB	25..>66	CDD:214630
		KRAB	25..64	CDD:279668
		C2H2 Zn finger	258..278	CDD:275368	3/19 (16%)
		zf-H2C2_2	271..293	CDD:290200	6/22 (27%)
		COG5048	282..639	CDD:227381	104/304 (34%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		zf-H2C2_2	298..321	CDD:290200	5/41 (12%)
		C2H2 Zn finger	314..334	CDD:275368	3/21 (14%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	14/24 (58%)
		C2H2 Zn finger	370..390	CDD:275368	10/19 (53%)
		zf-H2C2_2	383..407	CDD:290200	13/23 (57%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		zf-H2C2_2	439..463	CDD:290200	12/23 (52%)
		C2H2 Zn finger	454..474	CDD:275368	3/19 (16%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		zf-H2C2_2	495..519	CDD:290200	12/23 (52%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		zf-H2C2_2	523..545	CDD:290200	7/21 (33%)
		C2H2 Zn finger	538..558	CDD:275368	5/19 (26%)
		C2H2 Zn finger	566..586	CDD:275368
		zf-H2C2_2	578..603	CDD:290200
		C2H2 Zn finger	594..614	CDD:275368
		zf-H2C2_2	606..631	CDD:290200
		C2H2 Zn finger	622..642	CDD:275368
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	75/175 (43%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..309	CDD:290200	13/22 (59%)
		C2H2 Zn finger	301..321	CDD:275368	10/19 (53%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..396	CDD:290200	15/51 (29%)
		C2H2 Zn finger	385..407	CDD:275368	10/47 (21%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	6/21 (29%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000