Protein Alignment NUP160 and NUP120

DIOPT Version :10

• Sequence 1: NP_056046.2
• Gene: NUP160 / 23279
• HGNCID: 18017
• Length: 1402
• Species: Homo sapiens
• Sequence 2: NP_012866.1
• Gene: NUP120 / 853808
• SGDID: S000001540
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 1247
• Identity: 207/1247 - (16%)
• Similarity: 388/1247 - (31%)
• Gaps: 456/1247 - (36%)

Human    85 LDINLL--------NNAIRL----------------------------KFQNCSVLPGGVYVS-- 111
            :|.|||        ||.:.|                            ::.||.:|....|:.
Yeast     7 IDANLLQYYEKPEPNNTVDLYVSNNSNNNGLKEGDKSISTPVPQPYGSEYSNCLLLSNSEYICYH 71

Human   112 -ETQNRVIILMLTNQTVH----RLLLPHPSRMYRSELVVDSQMQSIFTDIGKVDFTDPCNYQLIP 171
             .:::.::.....:...|    .:.||:.|...|..|.:....|.:..::
Yeast    72 FSSRSTLLTFYPLSDAYHGKTINIHLPNASMNQRYTLTIQEVEQQLLVNV--------------- 121

Human   172 AVPGISPNSTASTAWLSSDGEAL-FALPCA---------SGGIFVLKLPPYD----IPGMV---- 218
                           :..||..| ..||.:         :|..|.|: .|||    :|..:
Yeast   122 ---------------ILKDGSFLTLQLPLSFLFSSANTLNGEWFHLQ-NPYDFTVRVPHFLFYVS 170

Human   219 ---SVVELKQSSVM----------QRLL---TGWMPTAIRGDQSPSDRPLSLAVHC-VEHDAFIF 266
               |||.|:...::          :.||   ..::.:..|.....|.......:.| :.|:.::.
Yeast   171 PQFSVVFLEDGGLLGLKKVDGVHYEPLLFNDNSYLKSLTRFFSRSSKSDYDSVISCKLFHERYLI 235

Human   267 ALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYMHAPKR 331
            .|.|:..|::|.......:...||:.        :..:...|..::   ..:|.||.:|.:.
Yeast   236 VLTQNCHLKIWDLTSFTLIQDYDMVS--------QSDSDPSHFRKV---EAVGEYLSLYNNT--- 286

Human   332 GQFCIFQLVSTESNRYSL-----DHISSLFTSQETLIDFALTSTDIWA-----LWHDAENQTVVK 386
                :..|:..|:..:.:     |....|..:.:..|...|:::.||:     |....|......
Yeast   287 ----LVTLLPLENGLFQMGTLLVDSSGILTYTFQNNIPTNLSASAIWSIVDLVLTRPLELNVEAS 347

Human   387 YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTER 451
            |:|.                    ||:                    ........|||.....|.
Yeast   348 YLNL--------------------IVL--------------------WKSGTASKLQILNVNDES 372

Human   452 NLDLSWSEL--KKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSHPLAL 514
            ..:..|.|.  |..|.|..|::|. .||:....:..|.||:..:..:.:.   :.|:.||.
Yeast   373 FKNYEWIESVNKSLVDLQSEHDLD-IVTKTGDVERGFCNLKSRYGTQIFE---RAQQILSE---- 429

Human   515 HLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISD--DVDIARDVICLIKCLR 577
                             :.:|.:...|..||...|.:|.:.:|..::  .:.:..|.|.|:.|.:
Yeast   430 -----------------NKIIMAHNEDEEYLANLETILRDVKTAFNEASSITLYGDEIILVNCFQ 477

Human   578 LIEESVTVDMSVIMEMSCYNLQSPEKAAE-----QILEDMITIDVENVMEDICSKLQEIRNPIHA 637
            ....|: ..::..:|...||:.|....:|     :.|....:....:|:..|..|..:|
Yeast   478 PYNHSL-YKLNTTVENWFYNMHSETDGSELFKYLRTLNGFASTLSNDVLRSISKKFLDI------ 535

Human   638 IGLLIREM-DYETEVE---------MEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGVHKIAST 692
               :..|: |..|.||         :|..|   :..|:::...:|...:..
Yeast   536 ---ITGELPDSMTTVEKFTDIFKNCLENQF---EITNLKILFDELNSFDIP-------------- 580

Human   693 RFLICRDLLILQQLLMRLGDAVIW-----------GTGQLFQAQQDLLHRTAPLLLSYYLIKWGS 746
              ::..||:..|   |:.|  :.|           |...:...:.  ||:   ||..:|.|.  .
Yeast   581 --VVLNDLINNQ---MKPG--IFWKKDFISAIKFDGFTSIISLES--LHQ---LLSIHYRIT--L 631

Human   747 ECLATDVPLDTLESNL--QHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLFSQP 809
            :.|.|.|..| |::.:  ||:|                    |:::|.:    ::.::.:|:.|.
Yeast   632 QVLLTFVLFD-LDTEIFGQHIS--------------------TLLDLHY----KQFLLLNLYRQD 671

Human   810 KAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNC----------QYVQLQDYIQLL 864
            |                               ||..|.|:.:.          .|.||..||..|
Yeast   672 K-------------------------------CLLAEVLLKDSSEFSFGVKFFNYGQLIAYIDSL 705

Human   865 HP---WCQVNVGSCRFMLGRCYLVTGEGQKAL-------EC-FCQAASEVGKEEFLDRLIRSEDG 918
            :.   ...:...|......|.|::.....|.:       || |....:||  :||:..:.....|
Yeast   706 NSNVYNASITENSFFMTFFRSYIIENTSHKNIRFFLENVECPFYLRHNEV--QEFMFAMTLFSCG 768

Human   919 EIVSTPRLQYYDKVLRLLDVIGLPELVIQLATSAITEA------GDD-WKSQATLRTCIFKHHLD 976
            .         :|:...:..:...||.:.....:.:.:.      ||. ||......|..::|
Yeast   769 N---------FDQSYEIFQLHDYPEAINDKLPTFLEDLKSENYHGDSIWKDLLCTFTVPYRH--- 821

Human   977 LGHNSQAYEALTQIPDSSRQ----LDCLRQLVVVLCERSQLQDLVEFP------YVNL------H 1025
                |..|..|:.:.|.:..    |.|:.:......:..|:::|.:|.      |:||      .
Yeast   822 ----SAFYYQLSLLFDRNNSQEFALKCISKSAEYSLKEIQIEELQDFKEKQHIHYLNLLIHFRMF 882

Human  1026 NEVVGII--------------------------------------------ESRARAVD------ 1040
            .||:.::                                            |...|.||
Yeast   883 EEVLDVLRLGHECLSDTVRTNFLQLLLQEDIYSRDFFSTLLRLCNAHSDNGELYLRTVDIKIVDS 947

Human  1041 LMTHNY-------YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCL 1098
            :::.|.       ::.||.|.:...:.|.|..|:::| :.:..::..:|    :..|||..:|.|
Yeast   948 ILSQNLRSGDWECFKKLYCFRMLNKSERAAAEVLYQY-ILMQADLDVIR----KRKCYLMVINVL 1007

Human  1099 RLIRPEY-AWIV 1109
            ......| .||:
Yeast  1008 SSFDSAYDQWIL 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP160	NP_056046.2	Nup160	28..543	CDD:432020	86/547 (16%)
NUP120	NP_012866.1	Nup160	91..495	CDD:432020	85/518 (16%)