Protein Alignment NUP160 and nup160

DIOPT Version :10

• Sequence 1: NP_056046.2
• Gene: NUP160 / 23279
• HGNCID: 18017
• Length: 1402
• Species: Homo sapiens
• Sequence 2: NP_001410773.1
• Gene: nup160 / 393635
• ZFINID: ZDB-GENE-040426-1603
• Length: 1394
• Species: Danio rerio
• Alignment Length: 1402
• Identity: 891/1402 - (63%)
• Similarity: 1108/1402 - (79%)
• Gaps: 14/1402 - (0%)

Human     4 AGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVESGKLFSVTRNRF 68
            ||.||||::|:.|.|||....||:.|: ::|.....:|.|||::|||||.|.:||||.|||.|||
Zfish     2 AGVLERSYIEICGFERETVSRFRQITL-NLGGVGVSSGGVKYADSAGGFSYEDSGKLLSVTSNRF 65

Human    69 IHWKTSGDTLELMEESLDINLLNNAIRLKFQNCSVLPGGVYVSETQNRVIILMLTNQTVHRLLLP 133
            |||.|||||::|:|:|||.||||||:||:...|.:|||||.:.||.|.||||::|:|:||||:||
Zfish    66 IHWATSGDTVQLVEQSLDTNLLNNAVRLRIPQCLLLPGGVSIQETLNNVIILIVTSQSVHRLVLP 130

Human   134 HPSRMYRSELVVDSQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTA---STAWLSSDGEALF 195
            ||:|||||:||.:.|||||||||||::...|.:..::|...|  |:|:|   |.||:|..|||||
Zfish   131 HPTRMYRSDLVTELQMQSIFTDIGKLNLNGPAHSYVLPFTQG--PHSSAPSTSAAWISHQGEALF 193

Human   196 ALPCASGGIFVLKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVE 260
            ||...||||.|:.||.:|..|.||::||||||:||| |.||||||||||||.||..:|||||.:|
Zfish   194 ALASPSGGIAVVTLPAHDQDGSVSILELKQSSMMQR-LAGWMPTAIRGDQSMSDMAVSLAVHQLE 257

Human   261 HDAFIFALCQDHKLRMWSYKEQMCLMVADMLEYVPV-KKDLRLTAGTGHKLRLAYSPTMGLYLGI 324
            .|.|||.|||||||||||.|.|||::|.||||::|| :.:::.:....|||||.:|.:.||.:.:
Zfish   258 DDTFIFTLCQDHKLRMWSLKHQMCVLVTDMLEFLPVGRGEVKASPAQAHKLRLFFSSSTGLCVAV 322

Human   325 YMHAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVKYIN 389
            |:..|||.|||:.|||:.||:||||||||:||::||||:||.||:|||||||.|.:||||.|||:
Zfish   323 YLSVPKRSQFCVLQLVANESSRYSLDHISTLFSTQETLVDFVLTATDIWALWLDNDNQTVAKYIS 387

Human   390 FEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTERNLD 454
            ||||..|.||.||:||.||||:.|.:||||||:||..||:|.:||..|:.|||||:.||.||..|
Zfish   388 FEHNTTGMWNQVFVQPSPEEEVHIGEDQDPREIYLDVLFSPLRFTASAIIKALQIYKRGPERYSD 452

Human   455 LSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSHPLALHLNPH 519
            |||.|||||||:.||:|||||||||||.||::|.||.|||.||||||||||:.||.|||||::|.
Zfish   453 LSWEELKKEVTVTVESELQGSVTEYEFCQEDYRLLQVEFWSKFYACCLQYQDVLSTPLALHVSPS 517

Human   520 TNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIARDVICLIKCLRLIEESVT 584
            |.|:|:||||::|||:|...||||||...|.|.:|:||.|::|.:::|||:.|::||||:.||:.
Zfish   518 TGMICVLKKGFVSFLLPCFAVDHLYLSSDEYLFSEEETPIAEDAEVSRDVLQLVQCLRLVNESLP 582

Human   585 VDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDICSKLQEIRNPIHAIGLLIREMDYET 649
            .:|:..|:.:...|.||||.:|:|||.::..|..||:.||.:|||:|.|||.|:.:|:||:|.||
Zfish   583 EEMAYEMDKALDELLSPEKVSEKILESLLANDTGNVIGDIANKLQDIYNPIAAMNMLLRELDLET 647

Human   650 EVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGVHKIASTRFLICRDLLILQQLLMRLGD-A 713
            :.|.: ..:..|.|.:|::|:|||||:.|..::|:.|.:.|.||.|:||||||||||.:|:|: |
Zfish   648 DAEPD-ARHAGQSLRVRISLSQLYGSSVAASLICQAVCQTAMTRTLLCRDLLILQQLYLRIGENA 711

Human   714 VIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGSECLATDVPLDTLESNLQHLSVLELTDSGALMA 778
            .|.|..||.|.||||:.|.:.||.:|:|:|..|..|::.||||.|.::|||||||||:||....:
Zfish   712 FISGGPQLLQLQQDLIPRCSNLLCTYHLLKQMSLTLSSSVPLDILNADLQHLSVLELSDSSTPAS 776

Human   779 NRFVSSPQTIVELFFQEVARKHIISHLFSQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCL 843
            :|.|.:|||:||||:|.||||.|:|.:|||......|:.|:||:||:::.:.|.|.||||||..|
Zfish   777 SRSVLNPQTVVELFYQSVARKTIMSQIFSQQDMESDQSVLHWPQMISSVLTLLCQALWPSNPSFL 841

Human   844 FLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEF 908
            |.|||||||||.|||:|::|:.|||||||||.||:||:|||.:|||||||:||.:||:||.||||
Zfish   842 FPECLMGNCQYAQLQEYVRLVGPWCQVNVGSYRFVLGQCYLASGEGQKALQCFQEAATEVNKEEF 906

Human   909 LDRLIRSEDGEIVSTPRLQYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKH 973
            |.:|..| |.|..:.|||.||:||||||:.||||||||:|||.|::||.||.:|||.|.|.||||
Zfish   907 LMKLTGS-DEETATAPRLLYYNKVLRLLEDIGLPELVIELATLAVSEATDDKRSQAALWTRIFKH 970

Human   974 HLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARA 1038
            ||||||||||||||||.||||||||||||||||||||:||:|||:|.|||||:|||.||||||||
Zfish   971 HLDLGHNSQAYEALTQNPDSSRQLDCLRQLVVVLCERAQLRDLVQFTYVNLHDEVVSIIESRARA 1035

Human  1039 VDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRP 1103
            |||||||||||||||||.||||||||||||||||||||||||||||:||.||||||||||||:.|
Zfish  1036 VDLMTHNYYELLYAFHINRHNYRKAGTVMFEYGMRLGREVRTLRGLQKQVNCYLAALNCLRLVSP 1100

Human  1104 EYAWIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLAQHDPS 1168
            :|||||||.|||.|:||||||||.||||...:|.|:||:||||:|||||..|||.||||||.||.
Zfish  1101 DYAWIVQPSSGAAYERPGASPKRTHDGEFAESPVNQQIDILELKDLEKEYVLARSRLTLAQQDPP 1165

Human  1169 AVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAAQAEAWAW 1233
            :.|:||.:|::|||.||||||||||:::|||||.||||||||||.|||||||:.|:..|.|.|.|
Zfish  1166 SAAIAGGASSQEMVALLVQAGLFDTSLTLCQTFNLPLTPVFEGLTFKCIKLQYKGDQDQTEVWNW 1230

Human  1234 LAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVPLPNWLINSYKKV 1298
            ||||||.:||||||:||||||||||:.|||::...|..:|.||||||||||||.|:||||:||:|
Zfish  1231 LAANQLPTVITTKETSATDEAWRLLAHYLEKFPSHNAPHHRCVINKLLSHGVPAPDWLINAYKEV 1295

Human  1299 DAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALG 1363
            |||.||||||||||||.|.:||.|:|||:|||||||||||.||||||.:|||||:||||||:.|.
Zfish  1296 DAAALLRLYLNYDLLEAAAELVLEFVDALLGKGHQYFGIERPLSATAALVWLPYTSIDQLLRNLS 1360

Human  1364 ENSANSHNIALSQKILDKLEDYQQKVDKATRDLLYRR 1400
            |:..|.   .:.:.:.|||.:|.:.||:::|..|..|
Zfish  1361 ESQINE---KMYRSLQDKLAEYHRLVDQSSRHRLMAR 1394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP160	NP_056046.2	Nup160	28..543	CDD:432020	323/518 (62%)
nup160	NP_001410773.1	Nup160	41..541	CDD:432020	319/502 (64%)