Protein Alignment NUP160 and nup120

DIOPT Version :10

• Sequence 1: NP_056046.2
• Gene: NUP160 / 23279
• HGNCID: 18017
• Length: 1402
• Species: Homo sapiens
• Sequence 2: NP_596674.1
• Gene: nup120 / 2540505
• PomBaseID: SPBC3B9.16C
• Length: 1136
• Species: Schizosaccharomyces pombe
• Alignment Length: 1203
• Identity: 228/1203 - (18%)
• Similarity: 419/1203 - (34%)
• Gaps: 328/1203 - (27%)

Human    82 EESLDINLLNNAIRLKFQNCSVLPGGVYVSET------------QNRVII------------LML 122
            ::|..|...::..:|..:.|.....|||.|..            |||.:.            |..
pombe    35 DDSEAIETADDNEKLFKKECVAYDAGVYTSNKSKGSQTLRWSIFQNRTLTIFDVSLNSKKEPLSK 99

Human   123 TNQTVHRLLLPHPSRMYRSELVVDSQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTASTAW- 186
            .|..:|     .||.:.:..:.......|..|.|..:.......|..:.......|::.....|
pombe   100 FNVKIH-----FPSNVMKDGVAFSFSEHSDTTIIYAITHARVLYYIRLSKTWFQLPDARLDDDWC 159

Human   187 --------LSSDGEALFALP----CAS---GGIFVLKLPPYD-------IPGMVSVVELKQSSVM 229
                    |:...:.:.|:.    |.|   ||:..:.|.|.|       |.....:..||:...:
pombe   160 LCYRPISFLNQKPDLMAAISTSEICVSFFNGGLTKIILNPKDASHYEQHIDDSSYLFSLKKYLSL 224

Human   230 QRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIFALCQDHKLRMWSYKEQMCLMVADMLEYV 294
            |         |.:.|....:..:|: :....::..:. |..|:||::.......|:...::.:.:
pombe   225 Q---------AFKADYRSPNTIISM-IFLSTYNVLVM-LSLDYKLKVLDLSTNQCVETIELSQTI 278

Human   295 -PVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYMHAPKRGQFCIFQLVSTESNRYSLDHI------ 352
             |::....||:          ..|...::.:|......|.|.|::| :..::.:.|:.:
pombe   279 LPLQSFPYLTS----------DHTTNSFIALYYPDNSHGSFSIYKL-NANAHSFKLNVVIEKGII 332

Human   353 -SSLFTSQ---ETLIDFALTSTD-------IWALWHDAENQTVVKYINFEHNVAGQWNPVFMQPL 406
             .||...:   ..|.||.|.|::       :...|....| ||::..|...:....::.|:...|
pombe   333 PPSLPDDEFIPWMLSDFQLISSEGSQSKFLLIIAWKSNLN-TVIQKCNLSLDQDESFSCVWSHSL 396

Human   407 PEEEIVIR---------DDQDPREMYLQSLFTPGQFTNEALCKALQIF----CRGTERNLD---- 454
            ....::.:         ...|..|::||.:|.... :.|::..||..|    .:.::..||
pombe   397 DSFSLIEKTFFDVPTNMSSGDISEIWLQHIFAHNT-SIESIQVALLSFQNSSSQVSKNKLDKFGA 460

Human   455 LSWSELKKEVTLAVENELQ----GSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSH----P 511
            |:.||||..|..::.:.:|    ..:|.|::  .|::.|....|.:| |..:.|   |.|    .
pombe   461 LTISELKNAVLSSIVSTIQIEPNSDLTGYDY--YEYKRLLYNEWERF-AKLVAY---LDHFGDEI 519

Human   512 LALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDD---------VDIAR 567
            |:::.:|...:..:.....::|:....|::.....|...|::..||   ||         :|:.|
pombe   520 LSINFDPSNAVTYINYANKVAFIRDPYLIESFDEEPLTKLISSLET---DDPSLIEGYQILDLGR 581

Human   568 DVICLIKCLRL---------IEESV----------------------TVDMSVIMEM--SCYNLQ 599
            .   |..|:..         :.|.|                      .||...|..:  :..:|:
pombe   582 S---LHSCMSFSTLSEIRYSLRELVQDLPSYSLFDTLWVFYDKHIYPNVDPDYISTLIDTLVSLE 643

Human   600 SPEKAAEQILEDMITIDVEN----------------VMEDICSKLQ-EIRNPIHAIGLLIREMDY 647
            :|.:..:.:::.:.:.|:.|                |::.|..|.| .|...|..:.|:..:.||
pombe   644 NPMRDIDSLIQRLRSFDIYNHSAQSPSLFLCASVARVLDSILKKFQVSIEGFIFLLSLITSQQDY 708

Human   648 ETEVEMEKGFNPAQPLNIRM----NLTQLYGSNTAGYIVCRGVHKIASTRFLICRDLLILQQLLM 708
                |::..|.....|.:.:    .|......|:|..:.......:.||.   |.  |...:.|.
pombe   709 ----ELQSKFAGCDKLFLSLLEDWRLVSFLLENSALLLEKFEEEDVDSTN---CN--LNTMEALA 764

Human   709 RLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGSECLATD--VPLD-TLESNLQHLSVLEL 770
            .:..|:     |.|.|            |:|      |||.:..  .||. |:.|:|..:.:.:.
pombe   765 SVNTAL-----QFFSA------------LNY------SECFSESQISPLHATVISSLSAIFIRDD 806

Human   771 TDSGALMANRFVSSPQTIVELFFQEVARKHIISHLFSQPKAPLSQTG-LNWPEMITAITSYLLQL 834
            |:      |..|:.   :||..|           ||.|..|.:...| ||
pombe   807 TE------NDLVTE---LVEKLF-----------LFKQYNACMQLIGWLN--------------- 836

Human   835 LWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEGQKALECFCQA 899
               |:|..::|:.|:                                 ||.:.|..||:.|| :.
pombe   837 ---SDPIAVYLKALI---------------------------------YLKSKEAVKAVRCF-KT 864

Human   900 ASEVGKEEFLDRLIRSEDGEIVSTPRLQ-----YYDKVLRLL--DVIGLPELVIQLATSAITEAG 957
            .|.|.........:..|..||......|     ||..:.:.|  :...:..|...|...|..|..
pombe   865 TSLVLYSHTSQFAVLREFQEIAEKYHHQNLLSCYYLHLSKKLFEESAYIDALEFSLLADASKETD 929

Human   958 DDWKSQA----TLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDLVE 1018
            |:..|.|    ||:|.......|..|     .||..:..:..:..||...|..|.::.::..|:.
pombe   930 DEDLSIAITHETLKTACAAGKFDAAH-----VALMVLSTTPLKKSCLLDFVNQLTKQGKINQLLN 989

Human  1019 FPYVNLHNEVVGIIESRA-RAVDLMTHN-YYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTL 1081
            :....|..:|..::|.:| :.:::.:.. :|.:|:::.....|||.|..:::|   :|.|.:.|.
pombe   990 YSMPTLRQDVDNLLERKAFQMINVESQPCWYNILFSWRYKHQNYRDAAAIIYE---KLSRYISTT 1051

Human  1082 RGLEKQGNC-----YLAALNCLRLIRPEYAWIV 1109
            ..:.|:...     ||..||.|.|:..|..||:
pombe  1052 ELIGKKERTFIIEHYLIVLNTLELLPKEDTWIL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP160	NP_056046.2	Nup160	28..543	CDD:432020	99/550 (18%)
nup120	NP_596674.1	Nup160	24..551	CDD:432020	99/550 (18%)