DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KLHL18 and kel

DIOPT Version :10

Sequence 1:XP_005265058.2 Gene:KLHL18 / 23276 HGNCID:29120 Length:584 Species:Homo sapiens
Sequence 2:NP_476589.4 Gene:kel / 35084 FlyBaseID:FBgn0001301 Length:1477 Species:Drosophila melanogaster


Alignment Length:578 Identity:216/578 - (37%)
Similarity:320/578 - (55%) Gaps:35/578 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    15 FSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEI 79
            :|..:..:|.:..|.|:|:|.:||||.|...|.:..|||:|||:..|||:||||: ..|.:|..|
  Fly   134 YSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARI 197

Human    80 VMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVR 144
            .:|.:|..|||.||::.|...:.:::.|||.||..|:.|||..::||||.||:.:|...||||:|
  Fly   198 TLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIR 262

Human   145 QFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWV 209
            :||:...|..|.:.|.::|.|||.||...:|||.|..|.|:.|:..|.::|.:||:|:|..:||:
  Fly   263 EFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWL 327

Human   210 RYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLP 274
            |||...|..:...|:.::|||....::::.||.::.|:.....|::|:.||..|||:|   ....
  Fly   328 RYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLP---TETK 389

Human   275 AFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVV 339
            :.||.||....:..::..:||       .|..::..||.:|.....|.:...|...|.|.|::|:
  Fly   390 SARTVPRKPVGMPKILLVIGG-------QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVL 447

Human   340 NGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDGN 404
            ...:||:||::|.||:.||:.|:|.||.|....:|.::||:     :|..||:|.||..||:||.
  Fly   448 GDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRST-----LGVAVLNGCIYAVGGFDGT 507

Human   405 SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL--QIFSSVEHYNHHTATW 467
            :.|||.|.|.|:||.|..:.|||:.||:.||.|..|.:|..||:||.  |..||||.||..|.||
  Fly   508 TGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTW 572

Human   468 HPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVAS 532
            ...|.|.::|...|...|.:.::..||:||.......|.|....:.|..:..|...|....:||.
  Fly   573 VNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAH 637

Human   533 CGRLYAVGGYDGQSNLSSVEMYDPETDCWTFM-----------------APMACHEGG 573
            .|.||.|||.||.|||:|||:|.|::|.|..:                 .||...|.|
  Fly   638 DGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMIDKPMXMEEQG 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18XP_005265058.2 BTB_POZ_KLHL18 19..134 CDD:349556 50/114 (44%)
PHA03098 34..562 CDD:222983 206/529 (39%)
BACK_KLHL18 135..241 CDD:350532 40/105 (38%)
KELCH repeat 282..327 CDD:276965 7/44 (16%)
KELCH repeat 331..374 CDD:276965 18/42 (43%)
KELCH repeat 378..427 CDD:276965 22/48 (46%)
KELCH repeat 430..474 CDD:276965 22/45 (49%)
KELCH repeat 477..521 CDD:276965 10/43 (23%)
KELCH repeat 524..567 CDD:276965 21/59 (36%)
kelNP_476589.4 BTB_POZ_KLHL2-like 136..255 CDD:349544 51/119 (43%)
PHA03098 150..675 CDD:222983 208/540 (39%)
KELCH repeat 439..482 CDD:276965 18/42 (43%)
KELCH repeat 486..530 CDD:276965 22/48 (46%)
KELCH repeat 533..580 CDD:276965 23/46 (50%)
KELCH repeat 582..626 CDD:276965 10/43 (23%)
KELCH repeat 629..674 CDD:276965 21/44 (48%)

Return to query results.
Submit another query.