Protein Alignment CLEC16A and ema

DIOPT Version :10

• Sequence 1: NP_056041.1
• Gene: CLEC16A / 23274
• HGNCID: 29013
• Length: 1053
• Species: Homo sapiens
• Sequence 2: NP_650542.1
• Gene: ema / 41992
• FlyBaseID: FBgn0038427
• Length: 1067
• Species: Drosophila melanogaster
• Alignment Length: 1068
• Identity: 497/1068 - (46%)
• Similarity: 665/1068 - (62%)
• Gaps: 152/1068 - (14%)

Human     1 MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQND 65
            || |||||.||..|...:|..||:||||||.:|.|||||:|.||.||||::|.|.||||||||:|
  Fly     1 MF-RSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHD 64

Human    66 SSVFDFFLEKNMFVFFLNILRQKSG--RYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIV 128
            |.||||||||||..:||:|:|||||  .:||||||||||||||||.:|||||||||||:||||:|
  Fly    65 SLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMV 129

Human   129 HKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTI 193
            ||||||||::|.|||.||||||||||.||:|||||||||||.|||||||||||||||||||||||
  Fly   130 HKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTI 194

Human   194 TLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHL 258
            :||||||  .|.:||.:||||||.|||||||||||.|::|||.||:||.:|::..|||:||||||
  Fly   195 SLNVYKV--QNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHL 257

Human   259 DHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSL---------------------ENQD-- 300
            ||||||:|||::..:.||.|||:|||::||:|||::||                     .|.|
  Fly   258 DHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDID 322

Human   301 -KGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPS--- 361
             :....|::|..|:|:|||.|||::.|||||::||.||||||.| ::.:...:|..|..:..
  Fly   323 IQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHS-VFKEGAAEILNSYVEHREVV 386

Human   362 IRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGTEGGSKG 426
            :..|.:|.|:||::|:                ...|:........:||:..::.....||..|:.
  Fly   387 VPGFGEPDESLEQALD----------------TVTGQSSSSSYALSEDSGVESSSPATTELDSQA 435

Human   427 IKTSGESEEIEMVIMERSKLSELAASTSVQEQNTTDEE-----KSAAATCSESTQWSRPFLDMVY 486
              .:.|:|:|::                   :|.||||     ||:::|.::..:.::||||.|.
  Fly   436 --DAVEAEQIKL-------------------RNITDEEKQLLQKSSSSTKADFAEMAKPFLDTVL 479

Human   487 HALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKT----TYNHPLAERLIRIM 547
            ||||..::||.||..|||:||||||:|:..|..|::      .|:.|    :|...|.|.|:.|:
  Fly   480 HALDCTENDYLALLSLCLIYAMSHNRGIKNEWFEQV------LAKSTRGAFSYKTALIEHLLNII 538

Human   548 NNAAQPDGKIRLATLELSCLLLKQQVLMSAG---CI---MKDVHLACLEGAREESVHLVRHFYKG 606
            ..::||..:|||.|:|::..||......|:.   ||   .:|:    |..||.:|:.::|:|||.
  Fly   539 TQSSQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDL----LFSARNQSMVVIRNFYKS 599

Human   607 EDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFF 671
            ||||||:|||||..|....:|||:|.||::|||||||||||||:|.:|||||:|||.||||||:|
  Fly   600 EDIFLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYF 664

Human   672 MLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSL 736
            :||....:...|.|:.||||...:|::.::||||||||||||||:.||....:|||.:|..|:.|
  Fly   665 LLRRTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLIL 729

Human   737 VEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRC 801
            ||||...|||||.||.|.|||::|.|.:||||.|:||:|: ....|::. |:|.|.|:|.|||||
  Fly   730 VEPDAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHR-GGVTHNRT-PLLSAKFLFDDHIRC 792

Human   802 IIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDP 866
            :.|||||.|||.:||:.||.:||.|:::|.|..:.|...| |:..::        ..|..|:|..
  Fly   793 MAAKQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVG-GTMVAS--------SSGGSGNSSG 848

Human   867 TVQRS-----VFASVDKVPGFAVA--------------------QCINQHSSPSLSSQSPPSASG 906
            :..||     :|::.::|||||..                    :.|...|:.....:||.|.||
  Fly   849 SSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSG 913

Human   907 ------------SPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETE 959
                        |||.| ..||..|....:|...||.....::  ||.:|:|. .:::.:
  Fly   914 SNLRADHSDRERSPSVS-MGSHSSSQSRENSQPRSTGNRSRES--SPRMPRPR-SEEIPL----- 969

Human   960 ADSKPSKNVARSAAVETASLSPSLVPAR 987
            .|.:.|:|.:..:....:..|.|..|.|
  Fly   970 EDFQHSRNNSPHSRGNPSPASRSHTPIR 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLEC16A	NP_056041.1	FPL	51..198	CDD:462884	122/148 (82%)
		CLEC16A_C	245..1022	CDD:466083	310/822 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..434		8/58 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	892..983		24/102 (24%)
ema	NP_650542.1	FPL	50..199	CDD:462884	122/148 (82%)
		CLEC16A_C	248..870	CDD:466083	280/680 (41%)