DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MGA and Mga

DIOPT Version :9

Sequence 1:	XP_005254300.1	Gene:	MGA / 23269	HGNCID:	14010	Length:	3115	Species:	Homo sapiens
Sequence 2:	XP_006234859.1	Gene:	Mga / 499874	RGDID:	1561597	Length:	3093	Species:	Rattus norvegicus

Alignment Length:	3124	Identity:	2589/3124 - (82%)
Similarity:	2785/3124 - (89%)	Gaps:	40/3124 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEEKQQIILANQDGGTVAGAAPTFFVILKQPGNGKTDQGILVTNQDACALASSVSSPVKSKGKIC 65
            |||||||||||||||||.||||||||||||||||||||||||||:||.||.|..|||.|||.|||
  Rat     1 MEEKQQIILANQDGGTVTGAAPTFFVILKQPGNGKTDQGILVTNRDARALLSRESSPGKSKEKIC 65

Human    66 LPADCTVGGITVTLDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDISPV 130
            ||||||||.||||||||||||||::||||||||||||||||||||||||||||||||||||||||
  Rat    66 LPADCTVGKITVTLDNNSMWNEFHNRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDISPV 130

Human   131 DNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILH 195
            |:|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   131 DSHRYKWNGRWWEPSGKAEPHILGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILH 195

Human   196 SMHRYLPRLHLVPAEKAVEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 SMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRD 260

Human   261 DGLNNKPQRDGKQKNSSDQEGNNISSSSGHRVRLTEGQGSEIQPGDLDPLSRGHETSGKGLEKTS 325
            |||::||||||||:||||||||::|||.|||||||||:||||..||.||:.||||||..||||..
  Rat   261 DGLSSKPQRDGKQRNSSDQEGNSVSSSPGHRVRLTEGEGSEIHSGDFDPVLRGHETSSLGLEKAP 325

Human   326 LNIKRDFLGFMDTDSALSEVPQLKQEISECLIASSFEDDSRVASPLDQNGSFNVVIKEEPLDDYD 390
            .|:|:||||||:|||. .||||||:||||..: ||||::|:::|||:.||:||||||||||||||
  Rat   326 NNVKQDFLGFMNTDST-HEVPQLKREISESHV-SSFEENSQISSPLNPNGNFNVVIKEEPLDDYD 388

Human   391 YELGECPEGVTVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNPEADHLSSKWLPSSPSGVAK 455
            |||||||||:|||||||||||||||||||||||||||||||||||.||||.|.||||:|| ||||
  Rat   389 YELGECPEGITVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNLEADHSSYKWLPNSP-GVAK 452

Human   456 AKMFKLDTGKMPVVYLEPCAVTRSTVKISELPDNMLSTSRKDKSSMLAELEYLPTYIENSNETAF 520
            |||||||.||||||||||||||:|||||||||||||||||||| ||||||||||.|||||:||.|
  Rat   453 AKMFKLDAGKMPVVYLEPCAVTKSTVKISELPDNMLSTSRKDK-SMLAELEYLPAYIENSDETGF 516

Human   521 CLGKESENGLRKHSPDLRVVQKYPLLKEPQWKYPDISDSISTERILDDSKDSVGDSLSGKEDLGR 585
            ||.|:|||.|||||.|||:||||.|||||.||||||.||.|||:..|.||.|..||.|||||||:
  Rat   517 CLSKDSENSLRKHSSDLRMVQKYTLLKEPHWKYPDIFDSSSTEKTHDSSKGSTEDSFSGKEDLGK 581

Human   586 KRTTMLKIATAAKVVNANQNASPNVPGKRGRPRKLKLCKAGRPPKNTGKSLISTKNTPVSPGSTF 650
            |||||||:|..:|.|||:|:||||.||||||||||:|.|||||||||||||.::||.||.||:||
  Rat   582 KRTTMLKMAIPSKTVNASQSASPNTPGKRGRPRKLRLSKAGRPPKNTGKSLTASKNIPVGPGNTF 646

Human   651 PDVKPDLEDVDGVLFVSFESKEALDIHAVDGTTEESSSLQASTTNDSGYRARISQLEKELIEDLK 715
            |||||||||||||||||||||||||||||||||||.||:|.:||||||.|.||||||||||||||
  Rat   647 PDVKPDLEDVDGVLFVSFESKEALDIHAVDGTTEEPSSVQTTTTNDSGSRTRISQLEKELIEDLK 711

Human   716 TLRHKQVIHPGLQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPFWNLTGTNPASPDAGFPFV 780
            :|||||||||.|||||||||||||||||||||||||||||||||||.||:|||||||||||||||
  Rat   712 SLRHKQVIHPALQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPLWNVTGTNPASPDAGFPFV 776

Human   781 SRTGKTNDFTKIKGWRGKFHSASASRNEGGNSESSLKNRSAFCSDKLDEYLENEGKLMETSMGFS 845
            ||||||||||||||||||||:||||||||||||:|||||||||||||||||||||||||||||||
  Rat   777 SRTGKTNDFTKIKGWRGKFHNASASRNEGGNSETSLKNRSAFCSDKLDEYLENEGKLMETSMGFS 841

Human   846 SN---APTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPPVSRKAKSQNRQATF 907
            ||   ||||||||||||||||||||||||||||||||||||:|:|||||...|||.|:||:|.|.
  Rat   842 SNAPTAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSHSVKPHSVTTASRKTKAQNKQTTV 906

Human   908 SGRTKSSYKSILPYPVSPKQKYSHVILGDKVTKNSSGIISENQANNFVVPTLDENIFPKQISLRQ 972
            |||||||||||||||||||||.|||..|||:||||....|:||..|.|||::||:.|||||||||
  Rat   907 SGRTKSSYKSILPYPVSPKQKNSHVSPGDKITKNSLSSASDNQVTNLVVPSIDESAFPKQISLRQ 971

Human   973 AQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIH 1037
            ||||..||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   972 AQQQHIQQQGTRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIH 1036

Human  1038 TIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFQRK 1102
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..:|
  Rat  1037 TIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHLHKK 1101

Human  1103 AAHRDPVFYDTLGEEAREEEEGIREEEEQLKEKKKRKKLEYTICETEPEQPVRHYPLWVKVEGEV 1167
            ||:|||:|||||||..||...|:||:||||||||||||||||:||.|||||||||||||||:|||
  Rat  1102 AANRDPLFYDTLGEGGREGGGGVREDEEQLKEKKKRKKLEYTVCEAEPEQPVRHYPLWVKVDGEV 1166

Human  1168 DPEPVYIPTPSVIEPMKPLLLPQPEVLSPTVKGKLLTGIKSPRSYTPKPNPVIREEDKDPVYLYF 1232
            |||||||||||||||:|||:||||:..|.|:||||..|||..|:|||||||||||||||||||||
  Rat  1167 DPEPVYIPTPSVIEPIKPLVLPQPDASSTTIKGKLTPGIKPTRAYTPKPNPVIREEDKDPVYLYF 1231

Human  1233 ESMMTCARVRVYERKKEDQRQPSSSSSPSPSFQQQTSCHSSPENHNNAKEPDSEQQPLKQLTCDL 1297
            ||||||||||||||||::|||.|...|||.|||||:||:|||||| ..||.||| |.||||.|||
  Rat  1232 ESMMTCARVRVYERKKDEQRQLSPPLSPSSSFQQQSSCYSSPENH-ATKELDSE-QTLKQLICDL 1294

Human  1298 EDDSDKLQEKSWKSSCNEGESSSTSYMHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSN 1362
            ||||||.|||:|||||||||||||||:||||||||||||||||||||||||||||||||||||||
  Rat  1295 EDDSDKSQEKTWKSSCNEGESSSTSYVHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSN 1359

Human  1363 MPQSLKVGSFIIELASQRKSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKME 1427
            |||||||||||||||||||.||||.||||||||||||||.||||||||||||||||||||||||:
  Rat  1360 MPQSLKVGSFIIELASQRKCRGEKTPPVYSSRVKISMPSSQDQDDMAEKSGSETPDGPLSPGKMD 1424

Human  1428 DISPVQTDALDSVRERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVNGKSYPQAKLLLG 1492
            |||||||||||||||||||||||||||||||:||||||||||||:||||||||||||||||||||
  Rat  1425 DISPVQTDALDSVRERLHGGKGLPFYAGLSPSGKLVAYKRKPSSTTSGLIQVNGKSYPQAKLLLG 1489

Human  1493 QMGALHPANRLAAYITGRLRPSVLDLSTLSTVISKVASNAKVAASRKPRTLLPSTSNSKMASSSG 1557
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| |||
  Rat  1490 QMGALHPANRLAAYITGRLRPSVLDLSTLSTVISKVASNAKVAASRKPRTLLPSTSNSKMA-SSG 1553

Human  1558 TATNRPGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVSTPQTLAGTQKFSIRPS 1622
            ..|||.||||||||||||||||||||||||||||||||||||||||||.|||.|.|.||||||||
  Rat  1554 PTTNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTPQPLTGPQKFSIRPS 1618

Human  1623 PVMVVTPVVSSEPVQVCSPVTAAVTTTTPQVFLENTTAVTPMTAISDVETKETTYSSGATTTGVV 1687
            |||||.||||||.|||||.||||| ||:|||.|||.|||..:||.||:..||.||||.|:|.|||
  Rat  1619 PVMVVAPVVSSEQVQVCSTVTAAV-TTSPQVVLENVTAVPSLTANSDMGAKEATYSSSASTAGVV 1682

Human  1688 EVSETNTSTSVTSTQSTATVNLTKTTGITT-PVASVAFPKSLVASPSTITLPVASTASTSLVVVT 1751
            |:||||.:|.|||||||||||||||||||| |||||:|||.||||| |||||||||||||:|:||
  Rat  1683 EISETNNTTPVTSTQSTATVNLTKTTGITTSPVASVSFPKPLVASP-TITLPVASTASTSIVMVT 1746

Human  1752 AAASSSMVTTPTSSLGSVPIILSGINGSPPVSQRPENAAQIPVATPQVSPNTVKRAGPRLLLIPV 1816
            .|||||:||||||||.||||||||||||||||||||||.||||.|||:|||.|||.|||||||||
  Rat  1747 TAASSSVVTTPTSSLSSVPIILSGINGSPPVSQRPENAPQIPVTTPQISPNNVKRTGPRLLLIPV 1811

Human  1817 QQGSPTLRPVSNTQLQGHRMVLQPVRSPSGMNLFRHPNGQIVQLLPLHQLRGSNTQPNLQPVMFR 1881
            |||||||||:.|.||||.|||||||||||||||||||||||||||||||:|||||||:||||:||
  Rat  1812 QQGSPTLRPIPNPQLQGQRMVLQPVRSPSGMNLFRHPNGQIVQLLPLHQIRGSNTQPSLQPVVFR 1876

Human  1882 NPGSVMGIRLPAPSKPSETPPSSTSSSAFSVMNPVIQAVGSSSAVNVITQAPSLLSSGASFVSQA 1946
            |||||:|||||.|.|.||| |||:||||||||:|||||||||..||||:|||||||||:||||||
  Rat  1877 NPGSVVGIRLPTPCKSSET-PSSSSSSAFSVMSPVIQAVGSSPTVNVISQAPSLLSSGSSFVSQA 1940

Human  1947 GTLTLRISPPEPQSFASKTGSETKITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQH 2011
            |||||||||||.|:.||||.||:|||.|:||||||||||||||||||||||||||||||:|:|||
  Rat  1941 GTLTLRISPPETQNLASKTASESKITPSTGGQPVGTASLIPLQSGSFALLQLPGQKPVPNSVLQH 2005

Human  2012 VASLQMKRESQNPDQKDETNSIKREQETKKVLQSEGEAVDPEANVIKQNSGAATSEETLNDSLED 2076
            |||||:|:||||.|||||:||||||:||||.|.|:.|.||||||::|||||...||:|.|:||:|
  Rat  2006 VASLQIKKESQNTDQKDESNSIKREKETKKALSSKDEVVDPEANIMKQNSGIIASEDTFNNSLDD 2070

Human  2077 RGDHLDEECLPEEGCATVKPSEHSCITGSHTDQDYKDVNEEYGARNRKSSKEKVAVLEVRTISEK 2141
            |||.||||.|.|:    .:|.|:|..||||||:| ||.:||.|.:|..|.|||..|.|||..||.
  Rat  2071 RGDLLDEESLRED----TRPYEYSYSTGSHTDED-KDGDEESGNKNENSPKEKQTVPEVRAGSEN 2130

Human  2142 ASNKTVQNLSKVQHQKLGDVKVEQQKGFDNPEENSSEFPVTFKEESKFELSGSKVMEQQSNLQPE 2206
            .:..|:||:.||:.||..:||||||:|.:||:    :|.|..|||||||||||:|.||:||.|.|
  Rat  2131 INIMTLQNVRKVRPQKYVEVKVEQQQGSENPD----DFLVLSKEESKFELSGSQVKEQKSNSQTE 2191

Human  2207 AKEKECGDSLEKD--RERWRKHLKGPLTRKCVGASQECKKEADEQLIKETKTCQENSDVFQQEQG 2269
            || |:|.|||.||  |||||||||||||.|.||.||:.|||||.||..|.|.||:||     |:.
  Rat  2192 AK-KDCEDSLGKDSLRERWRKHLKGPLTHKYVGISQDFKKEADVQLFTEMKPCQDNS-----ERD 2250

Human  2270 ISDLLGKSGITEDARVLKTECDSWSRISNPSAFSIVPRRAAKSSRGNGHFQGHLLLPGEQIQPKQ 2334
            ||:||||||..|...:.|||..|||.||:.:||||:||||.|..||:..||||.||..|.::|||
  Rat  2251 ISELLGKSGTIESGGIFKTEDGSWSGISSSAAFSIIPRRATKGRRGSRRFQGHFLLSKEHMKPKQ 2315

Human  2335 EKKGGRSSADFTVLDLE-EDDEDDNEKTDDSIDEIVDVVSDYQSEEVDDVEKVNNCVEYIEDDEE 2398
            :..|||||||||||||| ||:||:||||||||||||||||.|||||| |||| ||.|:||||||:
  Rat  2316 QANGGRSSADFTVLDLEDEDEEDENEKTDDSIDEIVDVVSGYQSEEV-DVEK-NNYVDYIEDDEQ 2378

Human  2399 HVDIETVEELSEEINVAHLKTTAAHTQSFKQPSCTHISADEKAAERSRKAPPIPLKLKPDYWSDK 2463
             ||:|||||||||||..:.||||||||||:|...:.|||||||:|:|||...|..|||.|.||||
  Rat  2379 -VDVETVEELSEEINFTYKKTTAAHTQSFRQQCHSLISADEKASEKSRKVSLISSKLKDDCWSDK 2442

Human  2464 LQKEAEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILTRAFSEIQGLTDQA 2528
            ..||.||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||
  Rat  2443 PHKETEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQA 2507

Human  2529 DKLIGQKNLLTRKRNILIRKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKMGSDEFDISPR 2593
            ||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||||||.:|||
  Rat  2508 DKLIGQKNLLSRKRSILIRKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKMGSDEFGLSPR 2572

Human  2594 ISKQQEGSSASSVDLGQMFINNRRGKPLILSRKKDQATENTSPLNTPHTSANLVMTPQGQLLTLK 2658
            ||.|.|||| |||||||||::|||||||||||::||||||.||.:|||:||||||||||||||||
  Rat  2573 ISTQLEGSS-SSVDLGQMFMSNRRGKPLILSRRRDQATENASPSDTPHSSANLVMTPQGQLLTLK 2636

Human  2659 GPLFSGPVVAVSPDLLESDLKPQVAGSAVALPENDDLFMMPRIVNVTSLATEGGLVDMGGSKYPH 2723
            |||||.|||||||.|||:.||||||.|.:|..||||||||||||||||||.|..|..|.|:||.|
  Rat  2637 GPLFSAPVVAVSPALLEAGLKPQVASSTMAQSENDDLFMMPRIVNVTSLAAEEDLGGMSGNKYLH 2701

Human  2724 EVPDSKPS-DHLKDTVRNEDNSLEDKGRISSRGN-RDGRVTLGPTQVFLANKDSGYPQIVDVSNM 2786
            ||||.||: |||:|...||.:||:|..||||||| ||.|:.||||||||||||||:|.:.|||.|
  Rat  2702 EVPDGKPALDHLRDVSGNEASSLKDTERISSRGNHRDSRMALGPTQVFLANKDSGFPHVPDVSTM 2766

Human  2787 QKAQEFLPKKISGDMRGIQYKWKESESRGERVKSKDSSFHKLKMKDLKDSSIEMELRKVTSAIEE 2851
            |.||||:|||:|||:||.::||||.|.||||:|||:|.|||||||||||||||||||||.|||||
  Rat  2767 QAAQEFIPKKMSGDLRGHRHKWKECELRGERLKSKESQFHKLKMKDLKDSSIEMELRKVASAIEE 2831

Human  2852 AALDSSELLTNMEDEDDTDETLTSLLNEIAFLNQQLNDDSVGLAELPSSMDTEFPGDARRAFISK 2916
            ||||.||||||||||||||||||||||||||||||||||| |||||..|:||||||||::|||||
  Rat  2832 AALDPSELLTNMEDEDDTDETLTSLLNEIAFLNQQLNDDS-GLAELSGSLDTEFPGDAQQAFISK 2895

Human  2917 VPPGSRATFQVEHLGTGLKELPDVQGESDSISPLLLHLEDDDFSENEKQLAEPASEPDVLKIVID 2981
            :.||:|:.|||.|||||:|||||||.||:|||||||||||||||||||||.:.||||||||||||
  Rat  2896 LAPGNRSAFQVGHLGTGVKELPDVQEESESISPLLLHLEDDDFSENEKQLGDTASEPDVLKIVID 2960

Human  2982 SEIKDSLLSNKKAIDGGKNTSGLPAEPESVSSPPTLHMKTGLENSNSTDTLWRPMPKLAPLGLKV 3046
            |||||||:|::|:.|||::|||||||||||||||.||||||.||| |||||||||||||||||||
  Rat  2961 SEIKDSLVSHRKSSDGGQSTSGLPAEPESVSSPPILHMKTGPENS-STDTLWRPMPKLAPLGLKV 3024

Human  3047 ANPSSDADGQSLKVMPCLAPIAAKVGSVGHKMNLTGNDQEGRESKVMPTLAPVVAKLGNSGASPS 3111
            |||.||||||||||||.||||||||||||||||.||:|||||.||:||||||||.||||||...|
  Rat  3025 ANPPSDADGQSLKVMPALAPIAAKVGSVGHKMNTTGSDQEGRGSKMMPTLAPVVTKLGNSGVPSS 3089

Human  3112 SAGK 3115
            |:||
  Rat  3090 SSGK 3093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MGA	XP_005254300.1	TBOX	74..264	CDD:238106	183/189 (97%)
		DUF4801	1041..1087	CDD:292677	45/45 (100%)
		HLH	2475..2525	CDD:278439	48/49 (98%)
Mga	XP_006234859.1	T-box_MGA-like	75..260	CDD:410321	179/184 (97%)
		DUF4801	1040..1081	CDD:406462	40/40 (100%)
		Herpes_BLLF1	<1519..1828	CDD:282904	264/311 (85%)
		Atrophin-1	1692..>2024	CDD:397323	288/333 (86%)
		bHLHzip_MGA	2454..2518	CDD:381481	62/63 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83690027
Domainoid	1	1.000	1985	1.000	Domainoid score	I267
eggNOG	1	0.900	-	-		E1_KOG3585
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49351
Inparanoid	1	1.050	4904	1.000	Inparanoid score	I121
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40124
OrthoDB	1	1.010	-	-		D1201455at2759
OrthoFinder	1	1.000	-	-		FOG0013994
OrthoInspector	1	1.000	-	-		oto138017
orthoMCL	1	0.900	-	-		OOG6_116156
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9510
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270