DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MGA and bi

DIOPT Version :9

Sequence 1:	XP_005254300.1	Gene:	MGA / 23269	HGNCID:	14010	Length:	3115	Species:	Homo sapiens
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	319	Identity:	125/319 - (39%)
Similarity:	177/319 - (55%)	Gaps:	37/319 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    15 GTVAGAAPTFFVILKQPGNG-------------KTDQGILVTNQDACALASSVS---SPVKSKGK 63
            |:.||..|..:     ||.|             ....|...|..:...|||:|:   .|.....:
  Fly   256 GSPAGPHPGLY-----PGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLR 315

Human    64 ICLPADCTVGGIT----VTLDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILV 124
            ...|.|   .|:.    |||:...:|.:|:...|||::||.||:|||..::.::|||:..||||:
  Fly   316 ALQPED---DGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILL 377

Human   125 MDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQE 189
            :||...|::|||::...|..:|||:|.:..|::|||:||:||..||.:.|||:|||||||..|:.
  Fly   378 LDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKH 442

Human   190 GHI---ILHSMHRYLPRLHLVPAEKAVEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDY 251
            |.:   ||:|||:|.||.|||   :|.::::|......|:.|.:|||.|||||||.:|||||||.
  Fly   443 GFVSTTILNSMHKYQPRFHLV---RANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDN 504

Human   252 NPFAKGFRDDGLNNKPQRDGKQKN-SSDQEGNNISSSSGHRVRLTEGQGSEIQPGDLDP 309
            |||||||||.|...:.::.....| .||.:..|.:..|..|..|..|...  :|..|.|
  Fly   505 NPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAG--RPPHLHP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MGA	XP_005254300.1	TBOX	74..264	CDD:238106	98/196 (50%)
		DUF4801	1041..1087	CDD:292677
		HLH	2475..2525	CDD:278439
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	12/62 (19%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	94/185 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810