DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNMBP and FUS2

DIOPT Version :10

Sequence 1:NP_056036.1 Gene:DNMBP / 23268 HGNCID:30373 Length:1577 Species:Homo sapiens
Sequence 2:NP_013959.1 Gene:FUS2 / 855272 SGDID:S000004845 Length:677 Species:Saccharomyces cerevisiae


Alignment Length:659 Identity:124/659 - (18%)
Similarity:231/659 - (35%) Gaps:238/659 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   706 DMYSRAQEELNLMLEEKQDESSRAET-LEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPS 769
            |.:.:..::|..::.:...:.|:.|. |.|.||  :|....:::|..:.|    |..:..:.:|.
Yeast    28 DYFHKNDDKLPEIVRKPTRKLSKHENKLNDKKF--TNKRPASLDLHSIVE----SLSNKKIYSPI 86

Human   770 GSVSAENPEQRMLE-----------KRAKVIEELLQTERDYIRDLEMC--IERIMV---PMQQAQ 818
            .:...:|..:..|.           |..|:::|...:|.:|..:|...  :.|..:   |..:.:
Yeast    87 NTEIFQNVVRLNLSPQIPNSPHEGCKFYKIVQEFYLSEVEYYNNLLTANNVYRKALNSDPRFKNK 151

Human   819 VPNIDFEG---LFGNMQMVIKVSK-----------------------------------QLLAAL 845
            :..:|...   ||||:..:..:||                                   ||.:..
Yeast   152 LVKLDSSDELLLFGNIDTIASISKILVTAIKDLLLAKQRGKMLDANEWQKIFTKNEVQQQLYSTF 216

Human   846 EISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEW--- 907
            :||:|    |..|...::.||..|..:|.:.   :|::......:.|          .:|:|   
Yeast   217 DISEA----FEQHLLRIKSTYTSYFVSHQKQ---MELFTTLRMNKNH----------FFNKWYEY 264

Human   908 -----GCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPES--HPD---KVPLTNAVLAV--KEI 960
                 ||   |.|...|..|::|:.:: :..:|.|.|..|.  .|:   |:..|....::  .::
Yeast   265 CLKESGC---IKLEDILKSPMKRLTQW-IDTLETLESCYEDILSPELGLKLSPTRRKYSLFSNKL 325

Human   961 NVNINEYKRR---------KDLVLKYRKGDEDS---LMEKISKLN-----------------IHS 996
            ...::|||..         .:::..|   |||.   |::...|.|                 :.|
Yeast   326 ETEVSEYKSNSMYNFSLTPSEIIQSY---DEDQFTHLLKPPDKQNKNICNASRQESNLDNSRVPS 387

Human   997 IIKKSNRVSSHLKHL-------TGFAPQIKDEVFEETE--------KNFR--------MQERLIK 1038
            ::..|:...|.:..|       |..|..|..::.||||        ..|:        :::.|:|
Yeast   388 LLSGSSSYYSDVSGLEIVTNTSTASAEMINLKMDEETEFFTLADHISKFKKVMKGLLELKKNLLK 452

Human  1039 ---SFIRDLSLYLQHIRESACVKVVAAVSMWDVCMER------GHRDL------EQFERVHRYIS 1088
               |.|.|:||.    |.:|..||:..        ||      .|.:|      ...:::|...:
Yeast   453 NDLSGIIDISLR----RINAWKKVIEC--------ERPSGAFFAHDNLISTMCSSYIDKLHEQKN 505

Human  1089 DQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKTLEE---- 1149
            ........| .|..|::||.::::                    :||....||||.:.|::    
Yeast   506 QVTILKLTE-LETDVMNPLERIIA--------------------HCTTVKSKLKDLQALKKDYML 549

Human  1150 -LQSARNN------------YEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQL 1201
             ||..:.|            ::.|..|:..|||.|                   ...:|..:|.:
Yeast   550 FLQEKKANVRDIKRDLLGMHFQNLQNQMKRELPVF-------------------ITLIHDTIECI 595

Human  1202 KPLLSLLKV 1210
              ||:.:||
Yeast   596 --LLNYIKV 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNMBPNP_056036.1 SH3_DNMBP_N1 6..56 CDD:212728
SH3_DNMBP_N2 70..123 CDD:212729
SH3_DNMBP_N3 149..199 CDD:212730
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244
SH3_DNMBP_N4 247..296 CDD:212731
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..395
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 591..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..659
RhoGEF 785..965 CDD:238091 43/237 (18%)
BAR_DNMBP 1017..1208 CDD:153273 47/238 (20%)
SH3_DNMBP_C1 1289..1345 CDD:212732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1487
SH3_DNMBP_C2 1517..1573 CDD:213017
FUS2NP_013959.1 RhoGEF 114..301 CDD:470622 39/207 (19%)
Blue background indicates that the domain is not in the aligned region.

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