Protein Alignment DNMBP and Dnmbp

DIOPT Version :10

• Sequence 1: NP_056036.1
• Gene: DNMBP / 23268
• HGNCID: 30373
• Length: 1577
• Species: Homo sapiens
• Sequence 2: NP_082305.1
• Gene: Dnmbp / 71972
• MGIID: 1917352
• Length: 1580
• Species: Mus musculus
• Alignment Length: 1595
• Identity: 1204/1595 - (75%)
• Similarity: 1324/1595 - (83%)
• Gaps: 33/1595 - (2%)

Human     1 MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65
            ||.||:|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Mouse     1 MEPGSMVRAIFDFCPSVSEELPLFVGDVIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65

Human    66 EGERLFVCICEFTSQELDNLPLHRGDLVIL-DGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
            ||||||||||||.|:||::|.||||||||| |..||||||||||||||.||||||||:||||||:
Mouse    66 EGERLFVCICEFVSRELNSLSLHRGDLVILDDSAPTAGWLQGRSCWGAWGFFPSSCVQELCLSSR 130

Human   130 SRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIF 194
            ||:||:||||.|.||||:|||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   131 SRRWHAQSALLQAPEYSLGQARALMGLSAQLDEELDFREGDLITIIGVPEPGWFEGELEGRRGIF 195

Human   195 PEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEP 259
            ||||||||||||||||||:|.:.||..||||||.|..|.|.|.|||:::.||||:|||||||||.
Mouse   196 PEGFVELLGPLRTVDESVNSRSGDDSAVNGEVDVPPEEAESGGDEDDQQSGTYGIALYRFQALET 260

Human   260 NELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETS 324
            |||||||||:|:||.|||||||||.|||:||:||:|||||||..|.|||.|.|||.|..:..|:|
Mouse   261 NELDFEVGDRIQILGTLEDGWLEGCLKGKTGVFPHRFVKLCPSNRTEETTAQPQESSFPKDSESS 325

Human   325 LDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPG 389
            :....::: |||.|.|..:.|.|.||..:....:.|..|:..|:..|..|.||:|.:|.   ||.
Mouse   326 VGKSGDSV-VEEARQEPWECEEERPDYDLPGQASVPQDHVAPEWTGDTISGQDKDASGS---SPD 386

Human   390 VEWEMPLATDSPTSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVGGSHPHSEQYPDLLPLEARTR 454
            |:.|.|||.|..|.||:|.|||:|||||||.||.:||||:|.|.||||..|:.:.:|:|||||||
Mouse   387 VDLERPLAKDLSTPDPSEEVNGVSSQPQVPIHPKVQKSQHYLTAGGSHQTSDPFSELVPLEARTR 451

Human   455 DYASLPPKRMYSQLKTLQKPVLPLYRGSSVSASRVVKPRQSSPQLH-NLASYTKKHHTS-----S 513
            ||:||||:|.|:|..:.|||...|.|.||::|||:.:|   |...| .:|||.:||.||     |
Mouse   452 DYSSLPPRRTYAQGWSFQKPASHLQRASSLTASRLDRP---SHFCHPAMASYAQKHQTSTENTAS 513

Human   514 VYSISERLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFS 578
            ::...||.|.:||.|.:|...:..|.|||| |.|||||||||||||||||:||.|||:.|:|.||
Mouse   514 LHDPPERPERRPGLQDRGPATDITTASQGD-SLDLDSKLTQQLIEFEKSLSGPSTEPETIVRRFS 577

Human   579 IMDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSR 643
            ||||.||||||||||..:..|..|||||.||||||||.||...|.||||||:.||.|.|||||||
Mouse   578 IMDFYSEKDIVRGSSNSLPSQAFPERRKTLRPPPPRPRTPTPISSHLLVDQSPKPVPTLVVRPSR 642

Human   644 PAPLPPSAQQRTNAVSPKLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMY 708
            ||||||.||||.|..|||..|...|..|..|||...||.:|..||.|||.:|.||.::|:|||..
Mouse   643 PAPLPPPAQQRMNTASPKPTSCAHPGWEAPEKEDSEHMEKSPAQTFPCPSMLARIRDVEQDLDTC 707

Human   709 SRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVS 773
            :||||||||:||||||:.|||||||.|:..||.|:||.:||||||:|||||||||||.||.||||
Mouse   708 TRAQEELNLLLEEKQDDPSRAETLETLRSYESTIQSLTLELQQLRDMTLLSSQSSSLAAPFGSVS 772

Human   774 AENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVS 838
            .||||||||||||||:.|||||||||||||||||||:|||:|||||||:||||||||||.|||||
Mouse   773 TENPEQRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVS 837

Human   839 KQLLAALEISDAV----------GPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHL 893
            |||||||||||||          |||||.|||||||||::|||||||||:|||:||||||.||||
Mouse   838 KQLLAALEISDAVGMSSCDCLVPGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHL 902

Human   894 QDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVK 958
            ||.|||||      ||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse   903 QDYLADLK------GCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVK 961

Human   959 EINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVF 1023
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:|||||
Mouse   962 EINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVF 1026

Human  1024 EETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQFERVHRYIS 1088
            |||||||||||||||||||||||||||||||||||||||:|:||:||||||.||||||:||||||
Mouse  1027 EETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAMSIWDLCMERGHHDLEQFEKVHRYIS 1091

Human  1089 DQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSA 1153
            |||||.||||||||||:||||||:|||||:|||||||||||||||||||||||||||||||||||
Mouse  1092 DQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSA 1156

Human  1154 RNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLI 1218
            ||||||||:|||||||||.||||.|||||:|||||||||||.||||||:|||||||...||||||
Mouse  1157 RNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLI 1221

Human  1219 AIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLAR 1283
            |||.||||||||||||||||||||||.:|||||||.||||:||.|||:|||||||||||:|||||
Mouse  1222 AIFLEEHSRVLQQLQVFTFFPESLPAPRKPFERKTTDRQSSRKTLLGMPSYMLQSEELRSSLLAR 1286

Human  1284 YPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFLKPYNP 1348
            |||||||..:|||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Mouse  1287 YPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTKGFVYSSFLKPYNP 1351

Human  1349 RRSHSDASVGSHSSTESEHGSSSPRFPRQNSGSTLTFNPSSMAVSFTSGSCQKQPQDASPPPKEC 1413
            |.|||||||.|||||||||..|||...||||.|.||||.::|.||||||....|||||| |.|:|
Mouse  1352 RCSHSDASVASHSSTESEHSGSSPGCHRQNSHSALTFNSNNMTVSFTSGLALTQPQDAS-PLKDC 1415

Human  1414 DQGTLSASLNPSNSESSPSRCPSDPDSTSQPRSGDSADVARDVKQPTATPRS-YRNFRHPEIVGY 1477
            ...||:.|.|..:.|:.||.|.|||..:.|.|.|:.||.|||:.||.:|.|. .|...|.|:|||
Mouse  1416 AHETLAVSWNTGHPETGPSTCSSDPGFSCQRRLGNPADGARDISQPASTLRGCQRGSPHSEVVGY 1480

Human  1478 SVPGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKI 1542
            ||||:|.|..|.:||.||..||||||......||.||||||||:|||||||||||||.|||:|:|
Mouse  1481 SVPGQNDQGSDSIKGSARVCQAPEDRDRGVGSSETEGNQVYFAIYTFKARNPNELSVLANQRLRI 1545

Human  1543 LEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKTEYT 1577
            .||||||||||||||||||:|||||||||||||||
Mouse  1546 HEFKDVTGNTEWWLAEVNGRKGYVPSNYIRKTEYT 1580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNMBP	NP_056036.1	SH3_DNMBP_N1	6..56	CDD:212728	47/49 (96%)
		SH3_DNMBP_N2	70..123	CDD:212729	44/53 (83%)
		SH3_DNMBP_N3	149..199	CDD:212730	48/49 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		18/32 (56%)
		SH3_DNMBP_N4	247..296	CDD:212731	39/48 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..395		21/59 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	591..624		20/32 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..659		16/19 (84%)
		RhoGEF	785..965	CDD:238091	159/189 (84%)
		BAR_DNMBP	1017..1208	CDD:153273	174/190 (92%)
		SH3_DNMBP_C1	1289..1345	CDD:212732	51/55 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1348..1487		81/139 (58%)
		SH3_DNMBP_C2	1517..1573	CDD:213017	49/55 (89%)
Dnmbp	NP_082305.1	SH3_DNMBP_N1	7..56	CDD:212728	47/48 (98%)
		SH3_DNMBP_N2	70..124	CDD:212729	44/53 (83%)
		SH3_DNMBP_N3	150..200	CDD:212730	48/49 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..245		19/33 (58%)
		SH3	248..297	CDD:473055	39/48 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..446		65/145 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..546		19/46 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..688		61/98 (62%)
		RhoGEF	784..968	CDD:238091	159/189 (84%)
		BAR_DNMBP	1020..1211	CDD:153273	174/190 (92%)
		SH3_DNMBP_C1	1292..1348	CDD:212732	51/55 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1356..1384		21/27 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1426..1514		42/87 (48%)
		SH3_DNMBP_C2	1520..1576	CDD:213017	49/55 (89%)