Protein Alignment DNMBP and dnbp-1

DIOPT Version :10

• Sequence 1: NP_056036.1
• Gene: DNMBP / 23268
• HGNCID: 30373
• Length: 1577
• Species: Homo sapiens
• Sequence 2: NP_001076722.2
• Gene: dnbp-1 / 4926960
• WormBaseID: WBGene00044989
• Length: 1523
• Species: Caenorhabditis elegans
• Alignment Length: 1929
• Identity: 348/1929 - (18%)
• Similarity: 577/1929 - (29%)
• Gaps: 800/1929 - (41%)

Human    16 SVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEGERLFVCICEFTSQ 80
            ||:::      .|::|:....::..:...|.|:|:.|......:..|..:..|:::..|..:||.
 Worm    21 SVAQD------QIVKVVREEGDWCHIQTIEGVSGRVPRVLTLPIVDPKRQPDEQVYCSIEAYTSI 79

Human    81 ELDNLPLHRGDLVILDGIPT---AGWLQG------RSCWGARGFFPSSCVRELCLSSQS------ 130
            ..|:|..  .:..|....|:   .|:|.|      ....|.||..|.:.:..|.:|::|
 Worm    80 RSDDLSF--AEFSIFVAKPSRSNPGYLDGFLVNDNAVQIGRRGLLPEAHLVNLHVSAESPMKPSF 142

Human   131 -RQWHSQSALFQIP---------EYSMG-QARALMGLSAQLDEELDFREGDVITIIGVPEPGWFE 184
             ..:......|:.|         .|::. .|||:.....:.:.||.|...::|::....:..|.|
 Worm   143 TTDFSEADVRFRTPATAPKAATSNYAVSPYARAVYDFQGEFENELSFSADEIISLRRRIDAEWLE 207

Human   185 GEL-EGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYG 248
            |.: ..|.||||..||:::..|  .|:..:|      :.|....|....:.||          :.
 Worm   208 GSIGSARVGIFPTSFVQIIVDL--PDDDTTS------LQNNRRSTTTENDGIG----------FA 254

Human   249 VALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQ 313
            ...:.|...:.:||....||.:|:|..:.|.|:                 :|.|...|:|..:|
 Worm   255 NVRHAFSGRQGDELTVNAGDTVRVLRMVNDEWV-----------------MCKDPDTEKTGIVP- 301

Human   314 EGSLARIPETSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSPLGHLTSEYDTDRNSYQDE 378
            .|.|    |..||                    ||.|                  |...::....
 Worm   302 VGFL----EVYLD--------------------EEDD------------------DNQSSNAMRR 324

Human   379 DTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVGGSHPHSEQY 443
            .|.|                   |||.|             |..:..:|.:.|       ::|..
 Worm   325 GTGG-------------------TSDFT-------------FGSSNNRSSFIS-------NAESS 350

Human   444 PDLLPLEARTR-DYA---SLPPKRMYSQLKTLQKPVLPLYRGSSVSASRVVKPRQSSPQLHNLAS 504
            .|..|...||. |:|   ::||                        |:...||.|      |.|:
 Worm   351 SDWRPPAGRTNTDWATFEAVPP------------------------AAPASKPAQ------NWAT 385

Human   505 YTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGTE 569
            :
 Worm   386 F---------------------------------------------------------------- 386

Human   570 PDKILRHFSIMDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPC---TPVSTSPHLLVDQNL 631
                                  ..:.|...:|.:.....|||||:..   :|::...::.....:
 Worm   387 ----------------------GEEWIAPVQLAKTSAPARPPPPKQSSIQSPINDIGNVADMFGM 429

Human   632 KPAPPLVVRPSRPAPLPPSAQQRTNAVSPKLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLV 696
            ...|    :||.||
 Worm   430 TDTP----KPSNPA--------------------------------------------------- 439

Human   697 RIEEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQ 761
                                                         |:|...:.    |:.|:|:
 Worm   440 ---------------------------------------------IQSAGSDF----EIGLISA- 454

Human   762 SSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERI----MVPMQQAQVPNI 822
                     :..|.|.|    :||.::||||:.:|..:|.|:....|.:    ::..:|..:
 Worm   455 ---------TEGASNDE----DKRCRIIEELISSELQFISDINSYTEAVDGTPLLNQKQKVI--- 503

Human   823 DFEGLFGNMQMVIKVSKQLLAAL-------EISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALL 880
                |......::::|..|:..|       :.:..:|..||..|.....||..|.:|.:...||
 Worm   504 ----LKNGCAQIVQLSANLVQLLTNEQIKPQDAQLIGACFLQLRKPFAQTYGFYFRNIEHINAL- 563

Human   881 EIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHP 945
               ....|.:|.::.:|.|:.....|.|.. .|:..:.:.:|:||..:|||.|.|::..||..|.
 Worm   564 ---TNSAKHEKTMESALQDIVKRMRESGSV-VIDGPTAVSRPIQRATKYPLFLNEIVKLTPLVHT 624

Human   946 DKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKH 1010
            |...||.|:..:..:...:||.||||:|..||...|:.:..|.:||:..||:.|||||.:..:..
 Worm   625 DHPKLTEAIKQMSNLGQKMNESKRRKELTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGS 689

Human  1011 LTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACV----KVVAA----VSMWD 1067
            ..|....::|..|:.........||.:..|...:.:|.:.:.....|    |||..    :|..:
 Worm   690 SLGVVKLLRDTDFDRLVCELDSAERRLVRFNYMMVIYRKKMFHETRVLMHKKVVEPRKKHLSSSE 754

Human  1068 VCMERGHRDLEQFER-VHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDF 1131
            :.::     |:.|.. :..:.|:   .|.:.|.|  ::..|..:      |.:|::||.|||:|
 Worm   755 IDLQ-----LQPFNHAIKTWASE---ANVRIRDE--IVKALRSI------PKRLIKKRNDKLMD- 802

Human  1132 YNCTERAEKLKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQ 1196
            |..:...||...|:...|:|   .:|||||.|:..:|||..:|...:....:...:|..    ..
 Worm   803 YEASRTKEKGLGKRDFAEIQ---KDYEALNTQVKQQLPKVTEYLTTVLATSMRTVSEQD----KA 860

Human  1197 ALEQLKPLLSLLKVAGREGN--------------LIAIFHEEHSRVLQQL--------------- 1232
            .:|.|:.|.:..|....|..              .:..:.::..:.||::
 Worm   861 LMETLRKLFNDAKSKAAEDQSKAARSLIIPTTICFVDYYDQDRMKPLQKIANKAIQNMKQRARSV 925

Human  1233 ----------------------QVFTFFP----ESLPA------------TKKPFERKTIDRQSA 1259
                                  ...||.|    |.||.            .:...||.||..::.
 Worm   926 SPKGSKPGTSSSSTTVTESPWATAPTFIPPAATEILPTITEGSTSTHKFRNQNATERNTILEKAT 990

Human  1260 RKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQD---LDVSLLEGDLVGVIKKKDPM 1321
            .|..||                      .:|.|..::  .||   |.::|.||.|: ::|:.|.:
 Worm   991 AKGRLG----------------------DIFVATSHY--PQDSGMLKIALAEGKLL-IVKQNDLV 1030

Human  1322 GSQNR-----WLIDNGVTKGFVYSSFLKPYN---------------------------------- 1347
            .:.||     ||..||.....:.||.||||.
 Worm  1031 LAVNREVPSMWLCYNGYYNAMLPSSILKPYTSIEKGVDVAKSAQFTGQTAQVVAPQAPVQNQNAP 1095

Human  1348 ------------------------------PRRSHSDASVGSHSSTESEHGSSSPRFPRQN---- 1378
                                          |.:...:.:....:|:..:..|..|:.|.||
 Worm  1096 KSQNLIDLEDLFGGPPQPAAAAHPTSLAFAPAQQQQNFATFDFTSSPLQPTSLVPQAPAQNAQFD 1160

Human  1379 ---SGSTLTFNPS-SMAVSFTSGSCQKQPQD----------------------------ASPPPK 1411
               :..||...|: .|.||..:...|:|.|:                            .:|||.
 Worm  1161 WNMAAKTLPLAPAPPMQVSQQAPQQQQQVQEGAGGANYNLDLDNLFSGLSTIDWGAKTSTAPPPL 1225

Human  1412 ECDQGTLSASLNP-------------SNSESSPSRCP-----------SDPDST----------- 1441
            ..:....:|:..|             .|..|.|...|           .||.||
 Worm  1226 YSNTPLDTATSPPVSAFRGVDFQTGVFNPNSLPDEAPPPLPVIVNPTRDDPFSTNFVPNFAAAAP 1290

Human  1442 ------------------------------------SQPRSGDSADVARDVKQPTATPRSYRNFR 1470
                                                :|.||..:|....:| .||.:..|..:..
 Worm  1291 ATSPFGTASNSSVQFPVSFDEAPSSMGSLGLPTGSMNQKRSASAAAQPTNV-WPTTSMMSRSDSP 1354

Human  1471 HPEIVGYSVPGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQ---VYFAV----------- 1521
            .|.|.....|........|..|.||   ||...:|.|    ::.||   :|.||
 Worm  1355 QPLIPSRPEPAVKNVYPSLNDGSAR---APTFATTFP----SQANQSLPMYSAVPNDTMSMNYAM 1412

Human  1522 ---------------------------------------------------------YTFKARNP 1529
                                                                     |.|..:..
 Worm  1413 PPMYDTTPQSPRVQLQQQHQPAAYDTPPTIAPIYDQLPNESPASTAIRPVLCQVKVDYDFLPQGS 1477

Human  1530 NELSVSANQKLKILEFKDVTGNTEWWLAE-VNGKKGYVPSNYIR 1572
            |::.|...:.:.:|:..|..||.||.|.: .:||.||||:.|.|
 Worm  1478 NQVEVKEGEVIGVLQRTDDDGNPEWLLIKRDSGKVGYVPAAYCR 1521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNMBP	NP_056036.1	SH3_DNMBP_N1	6..56	CDD:212728	8/39 (21%)
		SH3_DNMBP_N2	70..123	CDD:212729	14/61 (23%)
		SH3_DNMBP_N3	149..199	CDD:212730	15/50 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		5/32 (16%)
		SH3_DNMBP_N4	247..296	CDD:212731	9/48 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..395		6/59 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	591..624		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..659		4/19 (21%)
		RhoGEF	785..965	CDD:238091	46/190 (24%)
		BAR_DNMBP	1017..1208	CDD:153273	46/199 (23%)
		SH3_DNMBP_C1	1289..1345	CDD:212732	20/63 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1348..1487		40/245 (16%)
		SH3_DNMBP_C2	1517..1573	CDD:213017	22/125 (18%)
dnbp-1	NP_001076722.2	SH3	169..224	CDD:214620	16/54 (30%)
		SH3	250..306	CDD:214620	18/87 (21%)
		RhoGEF	465..644	CDD:470622	46/190 (24%)
		BAR	643..870	CDD:472257	67/250 (27%)
		PHA03247	<1221..1461	CDD:223021	37/247 (15%)
		SH3	1470..1522	CDD:473055	19/52 (37%)