DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNMBP and sif

DIOPT Version :10

Sequence 1:NP_056036.1 Gene:DNMBP / 23268 HGNCID:30373 Length:1577 Species:Homo sapiens
Sequence 2:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster


Alignment Length:1845 Identity:358/1845 - (19%)
Similarity:613/1845 - (33%) Gaps:583/1845 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   102 GWLQGRSCWGARGFFPSSCVRELCLSSQSRQ-WHSQSALFQIPEYSMGQARALMGLSAQLDEELD 165
            ||..|.|..|: |.......:::..|...|. |.|..:|.|  :.|:..:......:..|::..:
  Fly   715 GWRSGSSTIGS-GSGHGMMTQQIPGSGHKRSPWDSLPSLRQ--DSSLNDSGYKSARADSLEQRAE 776

Human   166 FREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPV 230
            |...|.:.       ..:..:.|.|.||..:.             |:.|.:...|.:.       
  Fly   777 FIRQDSLR-------SEYLSDRESRYGIVQQA-------------SIESTDSRMCYLT------- 814

Human   231 GEEEIGPDE---------DEEEPGTYGVALYRFQALEPNELDFEVGDKIR--------------- 271
             ..||..|:         ||::..:...:.|:.:|.......|.....:|               
  Fly   815 -SSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKK 878

Human   272 --ILATLEDGWLEG---SLKGRTGIF-PYRFVKLCPDTRVEETMALPQ-----EGSLAR-IPE-- 322
              |....:.|| :|   .|||.|.:| |      |.........|.|:     :|::.: |||  
  Fly   879 HQIELARKRGW-KGYWVCLKGTTLLFYP------CDSREGRSVEAAPKHLIIVDGAIMQPIPEHP 936

Human   323 --TSLDCLENTLG----------VEEQRHETSDHEA-------------------EE----PDCI 352
              ..:.||....|          ||.:....|.|.|                   ||    ...|
  Fly   937 KRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAI 1001

Human   353 ISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWE----------------MPLATDSP 401
            .|:.....:..|.....||:.:.....|       ..::||                |.......
  Fly  1002 ESDHKLKHMAELQQSVVTDQETRHQIQT-------QILQWEENLERLHCEQFRLRCYMASLQSGE 1059

Human   402 TSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVGGSHPH-SEQYPDLL--------------PLEA 451
            ..:|..::..:|.    |....|.|...: ||...|.. ..:.|.||              |:.:
  Fly  1060 LPNPKSLLTHVSR----PTKNTLNKLGVF-TVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLS 1119

Human   452 RTRDYASLPPKRMYSQ---LKTLQKPVLP------LYRGSSVS---------ASRVVKP------ 492
            |:...:|....:|.|:   .||. |..:|      :|...::|         |.|.:.|      
  Fly  1120 RSNSGSSRRSMQMNSRDEPEKTF-KVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVR 1183

Human   493 --RQSSPQLHN---------LASYTKKHHTSSV-----YSISERLEMKPGPQAQGLVMEAATHSQ 541
              ::...:.||         :.:|...|....|     |.:  .|:.....|..|..:||.....
  Fly  1184 VKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQV--ELQRTTLEQMWGFSVEAELIEN 1246

Human   542 GDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFN----SEKDIVRGSSKLITEQELP 602
            .:...:|...:::  :| :||:|    ..:.|::...||..|    |:.|::...|.|..||.|.
  Fly  1247 AERQDELCCYVSR--VE-DKSVA----MHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLS 1304

Human   603 ERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPP--SAQQRTNAVSPKLLSR 665
            ...::.|..|| ....:......::|..:.|.||..         ||  |.:..|..:.|     
  Fly  1305 MMMRSSRTEPP-DLVGIMRVTDDMIDSLVCPPPPTD---------PPVMSEEMITGLIVP----- 1354

Human   666 HRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEKQDESSRAE 730
                       .||..|.|.|..||                                :.|||.|.
  Fly  1355 -----------APGWNGTSKDLYSP--------------------------------EAESSPAT 1376

Human   731 TLED--------------------LKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSV--- 772
            :..|                    |...:....:.:.|::.|.:.....::.||   |:|||   
  Fly  1377 SFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSS---PTGSVTSS 1438

Human   773 ---SAENPEQRM--LEKRAKVIEELLQTERDYIRDLEMCIERIMVPM-QQAQVPNIDFEGLFGNM 831
               :|..|.:::  .||..||:.||:.|||.|::.|...:|..:.|| ::..:.|.:...||||:
  Fly  1439 VSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNI 1503

Human   832 QMVIKVSKQLLAALE--------------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEA 876
            ..::...:|.|..||                    :..|:|..||.:.:..: .|..:|.:|.:|
  Fly  1504 HEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKA 1567

Human   877 IALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTP 941
            ..:|...|.:..:|:.|  :..:.|..::.       .|.|:||||:||:::|||||.::.|.|.
  Fly  1568 QKVLHPNEGNHALQEFL--AARNPKQQHSS-------TLESYLIKPIQRILKYPLLLQQMRNLTD 1623

Human   942 ESHPDKVPLTNAVLAVKEINVNINEYKRRKD--------LVLKYRKGDEDSL---------MEKI 989
            ....:.|.|..|:..::::..:|||.:|..:        |..:::|..:..:         ...:
  Fly  1624 TRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGV 1688

Human   990 SKLNIHSIIKKSNRVSSHLK-HLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE 1053
            ..|||...:.|   :...|: |...|.  .|..|....::..|.:::|:....::.:..::.||.
  Fly  1689 EWLNISDFLGK---IKKGLELHAMCFV--FKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRY 1748

Human  1054 SACVKV----VAAVS--------MWDVCMERGHRDLEQFERVHRYISDQLFTNFKE---RTERLV 1103
            ...:.|    |.|.|        :|::...|.... .:.|:|  |:......:|:.   :|.|.:
  Fly  1749 QVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQ-RRSEKV--YVLSNSTADFRNAFLKTIRQI 1810

Human  1104 I--SPLNQLLSM--FTGPHKLVQKRFDK---LLDFYNCTERAEKLKD---------------KKT 1146
            |  |..|..:.|  |.|....|.....:   .:.:...::..|:.|.               ||:
  Fly  1811 IRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKS 1875

Human  1147 LEELQSARN-NYEALN-AQLLDELPK----FHQYAQGLFTNCVHG-----------------YAE 1188
            ..:..||.| :|:.|: :|..|:||.    .| ||.|    ..||                 ..|
  Fly  1876 GSQRHSAGNIDYDNLSGSQEADDLPPSVGVVH-YASG----HTHGQQMQPAGFRGRSKTVGDVTE 1935

Human  1189 AHCDF--VHQALEQLKPLLSLLKVAGREGNLIAIFH------------------EEHSRVLQQLQ 1233
            ..|..  .||..:|.:.....|.   ::|:..|..|                  ..||..::::.
  Fly  1936 ITCSSPEPHQQQQQQQQQQQQLM---QQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERID 1997

Human  1234 VFTFFPESLPATKKPFERKTIDRQSARKPLLG-LPSY-------------------MLQSEELRA 1278
                     |.||...|..:.......|..|| .|::                   ::||....|
  Fly  1998 ---------PGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPA 2053

Human  1279 S--------LLARYPPEKLFQAERNFNAAQ---DLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNG 1332
            |        |....|.|...::|...:|||   ..::||...   |.:...|...:|.:     .
  Fly  2054 SYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSS---GSLFASDARDNQTQ-----S 2110

Human  1333 VTKGFVYSSFLKP-----YNPRRS-----------HSDAS----------VGSHSSTESEHGSSS 1371
            .|:..::|....|     .:||:|           .|:|.          |..|.|.::......
  Fly  2111 RTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHK 2175

Human  1372 PRFPRQ----NSGSTLTFNPSSMA----VSFTSGSC----------QK--QPQDASPPPKECDQG 1416
            .|..|.    .:.:|..|....::    .:.|.|:|          :|  .|||.:....:..|.
  Fly  2176 QRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQN 2240

Human  1417 TLSASLNP----SNSE-------SSPSRCPSDPDSTS-----QPRSGDSADVARDVKQPTATPRS 1465
            ..|.|..|    .|::       .||||..::.|||.     ..||||..       :..||..|
  Fly  2241 DSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDET-------EEEATTSS 2298

Human  1466 YRNFRHPEIVGYSV--------PGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFAVY 1522
            ..:  |..::...|        |.|...::  |||..|...      ..||..:::|:.   .|.
  Fly  2299 LAS--HIVVIDKKVDKIFKAKSPERPASTK--VKGGRRQIY------ISPDRCKSQGSS---PVR 2350

Human  1523 TFKARNPNELSVSANQKLKILEFKD 1547
            ..|.::|........::|.:...:|
  Fly  2351 IIKIKSPRTSLSDQGKRLSVCSSRD 2375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNMBPNP_056036.1 SH3_DNMBP_N1 6..56 CDD:212728
SH3_DNMBP_N2 70..123 CDD:212729 6/20 (30%)
SH3_DNMBP_N3 149..199 CDD:212730 7/49 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 8/41 (20%)
SH3_DNMBP_N4 247..296 CDD:212731 14/69 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..395 14/98 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 591..624 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..659 4/21 (19%)
RhoGEF 785..965 CDD:238091 52/200 (26%)
BAR_DNMBP 1017..1208 CDD:153273 49/252 (19%)
SH3_DNMBP_C1 1289..1345 CDD:212732 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1487 42/203 (21%)
SH3_DNMBP_C2 1517..1573 CDD:213017 5/31 (16%)
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 26/131 (20%)
Tiam_CC_Ex 999..1096 CDD:408184 17/108 (16%)
RBD 1141..1207 CDD:128731 10/66 (15%)
PDZ 1220..1299 CDD:214570 19/87 (22%)
RhoGEF 1456..1647 CDD:238091 52/200 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 31/180 (17%)
PHA03307 2227..>2510 CDD:223039 38/169 (22%)
Blue background indicates that the domain is not in the aligned region.

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