Protein Alignment DNMBP and RhoGEF3

DIOPT Version :10

• Sequence 1: NP_056036.1
• Gene: DNMBP / 23268
• HGNCID: 30373
• Length: 1577
• Species: Homo sapiens
• Sequence 2: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Alignment Length: 1226
• Identity: 235/1226 - (19%)
• Similarity: 401/1226 - (32%)
• Gaps: 403/1226 - (32%)

Human   244 PGTYGVAL----YRFQALEPNEL---------DFEVGDKIRILATLEDGWLEGSLKGRTGIFPYR 295
            |.:||..|    ..::.|..:.:         |:|:...:|...|:..|          |.....
  Fly  2329 PQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNRETINSG----------GNSELN 2383

Human   296 FVKLCPDTRVEE--TMALPQEGSLARIPETSLDC-LENTLGV--------EEQRHETSDHEAEEP 349
            |  :..:||:.|  |..|..:.||.:.|.:..|. ||..:||        ...:..:|..:||..
  Fly  2384 F--MSNETRIYEHPTTVLKSQRSLRQSPGSRDDLNLEVAVGVGGDYIYRQPANQPRSSSVKAEFL 2446

Human   350 DCIISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVV----N 410
            ....:::.|..|.  |.:|.....:.|.:..:|...:.|....:.....|:.....|.|:    |
  Fly  2447 TTATTKSCTKTLD--TCDYWPRCAACQHKSVSGELKKGPSASGKPLTVLDNVQPHVTSVIVNEDN 2509

Human   411 GI---------SSQPQVPF---------HPNLQKSQYYSTVGGSHPHSEQ-------YPDLLPLE 450
            .:         .|.|...|         .|..|....:||   :...:|:       .|:.....
  Fly  2510 AVPGPQLRSLEKSNPSWTFLCSGIASICQPVQQTETDHST---AQEAAEEDIVIRKVKPNKSRRT 2571

Human   451 ARTRDYASLPPKRMY-----------------------SQLKTLQKPVL--PLYR---------- 480
            .|:|...|:..:|:|                       .|:|.:..|.|  |...
  Fly  2572 GRSRSLPSVMLRRLYLAGMPKPGSNEMGTTSDCAASLSQQIKAVSSPTLSEPCLEEQPQKGTEST 2636

Human   481 -----GSSVSA---------SRVVKPRQSSPQLH----------NLASYTKKHHTSSVYSISERL 521
                 |||..:         .|.:....:..|||          |.|..||...|::..||:..:
  Fly  2637 DVANTGSSAGSGGLGVLQKFKRTLNNFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMI 2701

Human   522 ----EMKPGPQAQG----------LVMEAATH------------SQGDGSTDLDSKLTQQL---- 556
                ...||.:|..          |:..::..            :.||....::.:..:|.
  Fly  2702 TTTTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRAT 2766

Human   557 --------------------IEFEK-------------SLAGPGTEPDKILRHFSIMDFNSEKDI 588
                                :...|             |:.||.....||.:|.:|    .|.|
  Fly  2767 MAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNI----GESD- 2826

Human   589 VRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQ 653
                             ||.|..|....|...:.|:.|....:.       ||........|...
  Fly  2827 -----------------KAERKAPESLPTRSLSQPNGLESYGMG-------RPDLEDSDSDSVAS 2867

Human   654 RTNAVS-----------------PKLLSRHR-PTCETLEKE-GPGHMGR-SLDQTSPC------- 691
            ...|:|                 |:.|...| ...|.|.|| ||...|| ..::|:..
  Fly  2868 NEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPE 2932

Human   692 ----PLVLVRI---EEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMEL 749
                |...|||   .|.:.....:..|.:|     ...::.::|||        |.::.......
  Fly  2933 LGWFPKEFVRIIHCPETDNFFIAHRAAADE-----AAAEEATARAE--------EGSVPVPVAAF 2984

Human   750 QQLREMTLLSSQSS-SLV---------APSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLE 804
            .:..::|:.:.||: :|:         |||....|: |:...:.:|: .:.|||.||.:|::.|.
  Fly  2985 AEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQ-PDHSTIIRRS-AVRELLDTEVNYVKLLA 3047

Human   805 MCIERIMVPMQQAQV----PNIDFEGLFGNMQMVIKVSKQLLAALE---ISDAVGPVFLG-HRDE 861
            ...:..: |....::    || ....:|.|:..:.|..::.|.||.   ..:.|..|||. |:..
  Fly  3048 AICDGYL-PAMSKRIDIFSPN-SIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKGF 3110

Human   862 LEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD-----SLADLKSLYNEWGCTNYINLGSFLIK 921
            |  .|..||..:..|:..||.|::.:..:..|::     :||:|.             |.:.|:.
  Fly  3111 L--CYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELP-------------LSAHLLA 3160

Human   922 PVQRVMRYPLLLMELLNSTPESH-----------------------------PDKVPLTNAVL-A 956
            ||||:.||||.|.|::.|..|..                             ||.....|..| |
  Fly  3161 PVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEA 3225

Human   957 VKEINVNINEYKRRKDLVLKYR------KGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFA 1015
            ::.|...:||.||..:.:.:::      ||....|......|.:.:..:|.|..:|... |..|.
  Fly  3226 MRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYT-LFLFD 3289

Human  1016 PQI---KDEVFEETE-----KNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMER 1072
            .|:   |.::.:.:.     :.|..:.|::.  :||..::...|:.|..:...:....:|.....
  Fly  3290 NQLVYCKRDIIKRSHFIYKGRIFLDRCRVVN--VRDGKMFGHTIKNSLRIYSESRDKWYDFSFRS 3352

Human  1073 GHRDLEQFERVHRYISDQLFTNFKERT---ERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNC 1134
            .:|.       ||::|    |...||.   :.|.:|.:       ||        |:     ||.
  Fly  3353 ANRK-------HRFLS----TLALERQFGGKALYVSEM-------TG--------FE-----YNY 3386

Human  1135 TERAEKLKDKKTLE----ELQSARNNYEA--------LNAQLLDELPKFHQYAQGL 1178
            .||.....|:...:    ||.:...:.|:        ..::|.:.|||..|...|:
  Fly  3387 EERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLCETLPKKSQSRDGI 3442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNMBP	NP_056036.1	SH3_DNMBP_N1	6..56	CDD:212728
		SH3_DNMBP_N2	70..123	CDD:212729
		SH3_DNMBP_N3	149..199	CDD:212730
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		235/1226 (19%)
		SH3_DNMBP_N4	247..296	CDD:212731	10/61 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..395		10/59 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	591..624		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..659		4/19 (21%)
		RhoGEF	785..965	CDD:238091	54/222 (24%)
		BAR_DNMBP	1017..1208	CDD:153273	35/185 (19%)
		SH3_DNMBP_C1	1289..1345	CDD:212732
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1348..1487
		SH3_DNMBP_C2	1517..1573	CDD:213017
RhoGEF3	NP_612024.4	SH3	2876..2942	CDD:214620	13/65 (20%)
		RhoGEF	3028..3234	CDD:238091	54/223 (24%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	25/146 (17%)