Protein Alignment DNMBP and Dnmbp

DIOPT Version :10

• Sequence 1: NP_056036.1
• Gene: DNMBP / 23268
• HGNCID: 30373
• Length: 1577
• Species: Homo sapiens
• Sequence 2: XP_008758708.1
• Gene: Dnmbp / 309362
• RGDID: 1583840
• Length: 1589
• Species: Rattus norvegicus
• Alignment Length: 1586
• Identity: 1192/1586 - (75%)
• Similarity: 1319/1586 - (83%)
• Gaps: 18/1586 - (1%)

Human     1 MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65
            ||.||||||||||||||||||||||||:||||.||||||||||||||||||||||||||||||||
  Rat    13 MEPGSVVRAIFDFCPSVSEELPLFVGDVIEVLTVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 77

Human    66 EGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQS 130
            ||||||||.|:|.|:|.::|.||||||||:||.||||||||||..||||||||||:.||||||||
  Rat    78 EGERLFVCTCDFISREPNSLSLHRGDLVIIDGTPTAGWLQGRSSLGARGFFPSSCIHELCLSSQS 142

Human   131 RQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFP 195
            ||||||:.|.|:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   143 RQWHSQNMLLQVPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFP 207

Human   196 EGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPN 260
            ||||||||||||.||||::|:.||..:|.|||....|.|...|||:::.||||:|||||||||.|
  Rat   208 EGFVELLGPLRTADESVNAGSGDDSTLNDEVDVSPEEVESEGDEDDQQAGTYGIALYRFQALESN 272

Human   261 ELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSL 325
            |||||||||||||.|||||||||.|||:|||||:|||||||..|.||||||||..|..:..|:|.
  Rat   273 ELDFEVGDKIRILGTLEDGWLEGRLKGKTGIFPHRFVKLCPSNRSEETMALPQGDSFPKNSESSA 337

Human   326 DCLENTLGVEEQRHETSDHEAEEPDCIISEAPT-SPLGHLTSEYDTDRNSYQDEDTAGGPPRSPG 389
            ..:.::: |||.|.:..:.|.|.||..:.|..: .||.|:..|...|:.|.||||.:|.   ||.
  Rat   338 GEMGDSV-VEEARQDPQECEEETPDSGLPEQTSEEPLDHVAPECVVDKISGQDEDASGS---SPD 398

Human   390 VEWEMPLATDSPTSDPTEVVNGISS-QPQVPFHPNLQKSQYYSTVGGSHPHSEQYPDLLPLEART 453
            |:.|.|.|.|..|.|.::.|||||| .||||..|..:|||:|.|.|||....:.:..|.||||:|
  Rat   399 VDLEGPRAEDPSTPDLSQEVNGISSLPPQVPLQPEEEKSQHYLTAGGSRQCPDTFSKLFPLEAKT 463

Human   454 RDYASLPPKRMYSQLKTLQKPVLPLYRGSSVSASRVVKPRQSSPQLHN-LASYTKKHHTSSVYSI 517
            |:|:||||:|.|:|..:||||...|:|.||::||||.:|...|   |. :||..:||.||:..:.
  Rat   464 RNYSSLPPRRTYTQGWSLQKPAPHLHRASSLTASRVNRPGHFS---HTAMASCAQKHQTSAENAA 525

Human   518 S-----ERLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHF 577
            |     ||.:.:||...:....|....|||| :.|||||||||||||||||:||.|||.||:|.|
  Rat   526 SLCCAPERPKRRPGLPDKEPATEITPASQGD-NLDLDSKLTQQLIEFEKSLSGPSTEPKKIVRRF 589

Human   578 SIMDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPS 642
            |||||.||||||||||..:..:..||||||||||||||.||.||||||||||:.||.||||||||
  Rat   590 SIMDFYSEKDIVRGSSNSLPSRNFPERRKALRPPPPRPHTPTSTSPHLLVDQSPKPGPPLVVRPS 654

Human   643 RPAPLPPSAQQRTNAVSPKLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDM 707
            |||||||..|||.|..|||..|...|..|..||||..:..:|..|..|||.||.||:::|.||||
  Rat   655 RPAPLPPPTQQRLNTASPKPTSCALPGWEAPEKEGSEYTEKSPAQLFPCPSVLARIQDVEHDLDM 719

Human   708 YSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSV 772
            ::||||||||:||||||||.||||||.||..||.|:|||:||||||||||||||||||.||||||
  Rat   720 HTRAQEELNLLLEEKQDESLRAETLETLKSYESTIQSLNLELQQLREMTLLSSQSSSLAAPSGSV 784

Human   773 SAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKV 837
            |.|.||||||||||||:.||||||:|||||||||:||:|||:||||||||||||||||||.||||
  Rat   785 STEKPEQRMLEKRAKVVAELLQTEKDYIRDLEMCVERVMVPLQQAQVPNIDFEGLFGNMQTVIKV 849

Human   838 SKQLLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKS 902
            ||||||||||:||||||||.|||||||||::|||||||||:||:||||||:|||||||.||||||
  Rat   850 SKQLLAALEITDAVGPVFLDHRDELEGTYRLYCQNHDEAISLLDIYEKDERIQKHLQDYLADLKS 914

Human   903 LYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEY 967
            ||:||||||||||||||||||||:|||||||||||||||||||||.|||:||||:||||.|||||
  Rat   915 LYHEWGCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKAPLTSAVLAIKEINANINEY 979

Human   968 KRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRM 1032
            ||||||||||||.|||||||||||||||||||||:|||||||||||||||:|||.||||||||||
  Rat   980 KRRKDLVLKYRKADEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEAFEETEKNFRM 1044

Human  1033 QERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQFERVHRYISDQLFTNFKE 1097
            ||||||||||||||||||||||||||||||:|:||:||||||.||||||:|||||||||||.|||
  Rat  1045 QERLIKSFIRDLSLYLQHIRESACVKVVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKE 1109

Human  1098 RTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSARNNYEALNA 1162
            |||||||:||||||:|||||:||||||||||||||||||||||||||||||:||||||||||||:
  Rat  1110 RTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKTLEDLQSARNNYEALNS 1174

Human  1163 QLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSR 1227
            |||||||||.||||.|||||:|||||||||||.:|||||:|||||||.:.|||||||||||||||
  Rat  1175 QLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQKALEQLQPLLSLLKASDREGNLIAIFHEEHSR 1239

Human  1228 VLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQA 1292
            |||||||||||||:|||.:|||||||.||||:||.|||:|||||||||||:||||||||||||..
  Rat  1240 VLQQLQVFTFFPEALPAPRKPFERKTTDRQSSRKALLGMPSYMLQSEELRSSLLARYPPEKLFHV 1304

Human  1293 ERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASV 1357
            :|||||||||||||||||||||||||||||||||||:||||||||||||||||||||.||||:||
  Rat  1305 QRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTKGFVYSSFLKPYNPRCSHSDSSV 1369

Human  1358 GSHSSTESEHGSSSPRFPRQNSGSTLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASL 1422
            .|||||||||..|||.|.||||.|.||||.:||.||||||..||||||.| |.:||...||..|.
  Rat  1370 VSHSSTESEHSGSSPSFHRQNSSSALTFNSNSMTVSFTSGLPQKQPQDTS-PLRECVPETLGVSS 1433

Human  1423 NPSNSESSPSRCPSDPDSTSQPRSGDSADVARDVKQPTATPRS-YRNFRHPEIVGYSVPGRNGQS 1486
            |..|.|:.||.|||||..:.|.|.|:.||..|::.||.:|.|. .|...|.|::||.||||:.|.
  Rat  1434 NTGNPETGPSPCPSDPGFSCQRRPGNPADGTREISQPASTLRGCQRRSLHSEVLGYPVPGRSDQG 1498

Human  1487 QDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGN 1551
            .|.:||.:|..|...||......|||||||||||:|||||||||||:|.|||:|:||||||||||
  Rat  1499 SDSIKGTSRACQTAGDRDRGLGSSEAEGNQVYFAIYTFKARNPNELTVLANQRLRILEFKDVTGN 1563

Human  1552 TEWWLAEVNGKKGYVPSNYIRKTEYT 1577
            ||||||||||||||||||||||||||
  Rat  1564 TEWWLAEVNGKKGYVPSNYIRKTEYT 1589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNMBP	NP_056036.1	SH3_DNMBP_N1	6..56	CDD:212728	47/49 (96%)
		SH3_DNMBP_N2	70..123	CDD:212729	39/52 (75%)
		SH3_DNMBP_N3	149..199	CDD:212730	49/49 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		14/32 (44%)
		SH3_DNMBP_N4	247..296	CDD:212731	42/48 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..395		23/60 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	591..624		22/32 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..659		15/19 (79%)
		RhoGEF	785..965	CDD:238091	158/179 (88%)
		BAR_DNMBP	1017..1208	CDD:153273	171/190 (90%)
		SH3_DNMBP_C1	1289..1345	CDD:212732	51/55 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1348..1487		81/139 (58%)
		SH3_DNMBP_C2	1517..1573	CDD:213017	50/55 (91%)
Dnmbp	XP_008758708.1	SH3_DNMBP_N1	18..68	CDD:212728	47/49 (96%)
		SH3_DNMBP_N2	82..135	CDD:212729	39/52 (75%)
		SH3_DNMBP_N3	161..211	CDD:212730	49/49 (100%)
		SH3	259..308	CDD:473055	42/48 (88%)
		RhoGEF	797..977	CDD:238091	158/179 (88%)
		BAR_DNMBP	1029..1220	CDD:153273	171/190 (90%)
		SH3_DNMBP_C1	1301..1357	CDD:212732	51/55 (93%)
		SH3_DNMBP_C2	1529..1585	CDD:213017	50/55 (91%)