DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNMBP and gef1

DIOPT Version :10

Sequence 1:NP_056036.1 Gene:DNMBP / 23268 HGNCID:30373 Length:1577 Species:Homo sapiens
Sequence 2:NP_592943.1 Gene:gef1 / 2542635 PomBaseID:SPAC24H6.09 Length:753 Species:Schizosaccharomyces pombe


Alignment Length:1008 Identity:193/1008 - (19%)
Similarity:338/1008 - (33%) Gaps:384/1008 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   307 ETMALPQEGSLARIPETS----LDCLEN---TLGVEEQRHETSDHEAEEPDCIISEAPTSPLGHL 364
            ||:|   ...|.|:|.||    ..|::.   .|.:....:..|..::::.|..:||:        
pombe    19 ETLA---NRDLPRLPGTSKLHRAACIKRKSINLSLPSNSYSLSYRQSDDTDGDVSES-------- 72

Human   365 TSEY--DTDRNS-------YQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPF 420
            .|||  .:.|.|       .||..|...||                          :|||.:..|
pombe    73 QSEYRLSSGRRSRASFARALQDPQTPNTPP--------------------------VSSQHRRFF 111

Human   421 HP---NLQKSQYYSTVGGSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYRGS 482
            ..   ||..|....::.|              ::...:.::|.|.|:|....          |..
pombe   112 SEGSFNLPNSNMSHSLNG--------------DSTASNSSTLTPNRIYGDRN----------RQD 152

Human   483 SVSASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHSQGDGSTD 547
            ...:||...|...|...:|..:..:|.||::..:.:.|       :..||....|.:|....|..
pombe   153 YAQSSRYTLPSLPSSPSYNCPTTLRKIHTNTSSNGTSR-------RVSGLGSFMAQNSSETSSNR 210

Human   548 LDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQELPERRKALRPPP 612
            ..:.|             ||:..|:           .||   |.|..|                 
pombe   211 TSAYL-------------PGSSTDE-----------QEK---RSSVTL----------------- 231

Human   613 PRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSPKLLSRHRPTCETLEKEG 677
                                            |.:|.|.....:.:||                 
pombe   232 --------------------------------ASMPSSHSSTASLLSP----------------- 247

Human   678 PGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEKQDES-SRAETLEDLKFCESN 741
                   ||.||                  :|...:...|.||  .||| ||.     :.:..::
pombe   248 -------LDTTS------------------FSTKLDSTILALE--TDESLSRT-----ISYATTS 280

Human   742 IESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMC 806
            :.|  ...::|.:.:|..|::||:          |||.:.::|||.:|:||:.||..|:.||...
pombe   281 LPS--TPGKRLSKESLAMSEASSI----------NPEYKRIKKRANLIKELVTTEAAYLNDLIAI 333

Human   807 IERIMVPMQQAQVPN-IDFEGLFGNMQMV--------------------IKVSKQLLAALEISDA 850
            .:...:.:::....| :|.:.:||:::.:                    :.:..||:..|..:  
pombe   334 QQSYGLRVKECSALNPVDAQTVFGDIESLLTFTVEFHSRLYQAGEGSWRVNLDTQLIDPLPCN-- 396

Human   851 VGPVFLGHRDELEGTYKIYCQNHDEAIALLE-----------IYEKDEKIQKHLQDSLADLKSLY 904
            :|.:||....|:...|..||...|....::.           |.|.|:.:||:            
pombe   397 LGLIFLESLSEIGQIYTGYCNRQDSVFKIITKWREKPATASWIMEGDKIVQKY------------ 449

Human   905 NEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYK- 968
                 ||..:|||.:|||:||:::|||||.::::.||||..::..|..:...::|:...||:.: 
pombe   450 -----TNAWDLGSLIIKPLQRLLKYPLLLQKIIDVTPESSSERPDLVLSYQLLQELISGINQKQK 509

Human   969 ---RRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNF 1030
               :|..|...:::....||:.|.:     |...:....|:.||              .:...||
pombe   510 PSHKRGSLSASHKRDAAWSLLYKAT-----SNKSRPTTTSTELK--------------TDARLNF 555

Human  1031 RMQERLIKSFIRDLSLYLQHIRES-ACVKVV-AAVSMWDVCMERGHRDLEQFERV---------- 1083
            :.|             .||..|:. |.:|.: |.:..|.|.:   ||....||:|          
pombe   556 QRQ-------------VLQDFRQRFAILKALHATLETWYVTV---HRGFSVFEKVLAELEGLSAL 604

Human  1084 ------------HRYISDQLFTNFKERTE----RLVISPLNQLLSMFTGPHKLVQKRFDKLLDFY 1132
                        :..::..:..|...:.:    ..:::|:..:|       :::|    |::.|.
pombe   605 EPEDKPVDTWRKYHLLAHMMTANLPSQIQTSLNSSILNPITNIL-------RVIQ----KVIQFI 658

Human  1133 NCTE---RAEKLKDKKTL--EELQSARNNYEALNAQLLDELPKFHQYAQGL-------------- 1178
            ...|   .|:||:...||  :|..|...::..:...|      :..||||.              
pombe   659 ISAEFVIPAQKLEAISTLVEKEFHSVVYHFIGIQRSL------YENYAQGFLFLIPQDMRDSILE 717

Human  1179 ----FTNCVHGYAEAHCDFVHQALEQLKPLLSL 1207
                :...|..:...|.| ....||:|...:||
pombe   718 ETQDYAELVRAFEPMHYD-DEVLLEELMKSVSL 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNMBPNP_056036.1 SH3_DNMBP_N1 6..56 CDD:212728
SH3_DNMBP_N2 70..123 CDD:212729
SH3_DNMBP_N3 149..199 CDD:212730
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244
SH3_DNMBP_N4 247..296 CDD:212731
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..395 14/68 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 591..624 2/32 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..659 3/19 (16%)
RhoGEF 785..965 CDD:238091 51/211 (24%)
BAR_DNMBP 1017..1208 CDD:153273 43/242 (18%)
SH3_DNMBP_C1 1289..1345 CDD:212732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1487
SH3_DNMBP_C2 1517..1573 CDD:213017
gef1NP_592943.1 COG5099 79..>304 CDD:227430 67/418 (16%)
RhoGEF 312..505 CDD:238091 51/211 (24%)
Blue background indicates that the domain is not in the aligned region.

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