DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNMBP and gef3

DIOPT Version :10

Sequence 1:NP_056036.1 Gene:DNMBP / 23268 HGNCID:30373 Length:1577 Species:Homo sapiens
Sequence 2:NP_595845.1 Gene:gef3 / 2540334 PomBaseID:SPBC29A3.17 Length:525 Species:Schizosaccharomyces pombe


Alignment Length:572 Identity:123/572 - (21%)
Similarity:231/572 - (40%) Gaps:120/572 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   726 SSRAETLED-LKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVI 789
            ::...|||| ||.......:|:....:.|     |:::|.......:::..:.::.::    .|:
pombe    22 ANSTHTLEDTLKLRPDWTIALSQHETETR-----STRTSCSTTTESTIAMRSKQKAII----SVL 77

Human   790 EELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMV--------IKVSKQLL---- 842
            ||...:|..|:.||.:. :|........:|...:::.:|....::        |::.|.|.    
pombe    78 EEFRDSEAAYVHDLHVA-QRYYADRLSDRVKKSEWKDVFEIFLVLCKQASLFEIEMHKSLNDEIN 141

Human   843 -------AALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQ--DSLA 898
                   |.|:...:|..:||....:|...|..||...:.....:|.:.|:..|.::||  ||:|
pombe   142 YILDDQDACLKPKPSVAQLFLSWLPKLSAVYGRYCVIQENIGKKVEKWMKNSSISEYLQECDSMA 206

Human   899 DLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPES-HPDKVPLTNAVLAVKEINV 962
            .::|  |.|      ||.|||:|||||.::|||||.:|..|.... ..|.|.|..|....:..:.
pombe   207 KIES--NSW------NLDSFLVKPVQRFLKYPLLLNQLYRSASLGIISDYVLLGEACHKSEIASQ 263

Human   963 NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRV--SSHLKHLTGFAPQIKDEVFEE 1025
            .:||.|||:|:::...  |..|..:::..|:..||.||..::  |:::.::....|         
pombe   264 RMNELKRRRDIIITAL--DSVSNSQEVLLLSTDSIDKKIAKLQNSTNIFYVPEHEP--------- 317

Human  1026 TEKNFRMQERLIKSFIRDLS---LYLQHIRESAC----------VKVVAAVSMWDV-CMERGHRD 1076
                       |.:|:..||   ..|.::|.:.|          :|....|..:.| |.:....|
pombe   318 -----------ILAFVHQLSSSYTNLLNLRSAICDWLKFSRYHYLKFFTFVEAYSVFCKDTKSAD 371

Human  1077 --------LEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYN 1133
                    |:.       |:........|:.:..|:.|::..:..|..|..:......|...|  
pombe   372 KWALISVALDN-------IAKGAVLRLTEQCQTSVLRPISNGILFFRNPLCVTDVWIKKATAF-- 427

Human  1134 CTERAEKLKDKKTLEE-LQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQA 1197
                 .|.:..:..|| |:|    :..|:..||:|||.|.:.|:.:...|:..:|:....|....
pombe   428 -----SKRRQSQVFEEDLES----FPLLSNCLLEELPLFLEMARNVTDECILAFAQIQATFYDTI 483

Human  1198 LEQLKPLLSLLKVAGREGNLIAIFHEEHSRV--LQQLQVFTFFPESLPATKK 1247
            .:.|:|:::...:.            :|..:  ::.:..||....|:.::.|
pombe   484 QKVLEPVVAKFNLT------------DHQDIPSIESIMDFTSLRSSMESSPK 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNMBPNP_056036.1 SH3_DNMBP_N1 6..56 CDD:212728
SH3_DNMBP_N2 70..123 CDD:212729
SH3_DNMBP_N3 149..199 CDD:212730
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244
SH3_DNMBP_N4 247..296 CDD:212731
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..395
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 591..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..659
RhoGEF 785..965 CDD:238091 54/201 (27%)
BAR_DNMBP 1017..1208 CDD:153273 39/213 (18%)
SH3_DNMBP_C1 1289..1345 CDD:212732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1487
SH3_DNMBP_C2 1517..1573 CDD:213017
gef3NP_595845.1 RhoGEF 76..267 CDD:214619 54/199 (27%)
Blue background indicates that the domain is not in the aligned region.

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