Protein Alignment DNMBP and dnmbp

DIOPT Version :10

• Sequence 1: NP_056036.1
• Gene: DNMBP / 23268
• HGNCID: 30373
• Length: 1577
• Species: Homo sapiens
• Sequence 2: XP_004915928.1
• Gene: dnmbp / 100498526
• XenbaseID: XB-GENE-967684
• Length: 1545
• Species: Xenopus tropicalis
• Alignment Length: 1645
• Identity: 912/1645 - (55%)
• Similarity: 1123/1645 - (68%)
• Gaps: 168/1645 - (10%)

Human     1 MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65
            ||.||||||||||||||||||.||.||:||||.|:|||||||.||.:|||||.||||.::|||||
 Frog     1 MEVGSVVRAIFDFCPSVSEELTLFAGDVIEVLTVIDEFWLLGTKEGITGQFPVSFVEELSIPSLK 65

Human    66 EGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQS 130
            .||:|:||..||||.|...|.|.||||::|:|..|:.|||||||||::||||.|||:|.||||:|
 Frog    66 HGEKLYVCTSEFTSHEPGALCLQRGDLLVLEGTLTSSWLQGRSCWGSKGFFPLSCVQEFCLSSRS 130

Human   131 RQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFP 195
            ||. .|::..::|.|::|||||::||||||:|||||||||:|||.||||.|||||||.|||||||
 Frog   131 RQL-CQNSNLELPSYAIGQARAILGLSAQLEEELDFREGDIITITGVPESGWFEGELNGRRGIFP 194

Human   196 EGFVELLGPLRTVDESVSSGNQDDC-------IVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYR 253
            |||||||.|||..|..:.....||.       :....|.....:|  ...|.|::.||:.||||:
 Frog   195 EGFVELLNPLRVSDVRIIHSTYDDFKHDKLAEVAQFPVRGKCNKE--NHRETEDQDGTFAVALYK 257

Human   254 FQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLA 318
            |:|:|..||||||||:|||:.|||||||||.|.|:.||||:|||||          ..|::.|..
 Frog   258 FEAMEQRELDFEVGDRIRIIKTLEDGWLEGELYGKRGIFPHRFVKL----------ESPEKNSFY 312

Human   319 RIPE------TSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSPLGHLTSEYDTDRNSYQD 377
            :.||      ||.| |:.:.        |.:|...:|                        .|.|
 Frog   313 KTPEGTKNSNTSRD-LDFSF--------TDNHSGSDP------------------------HYWD 344

Human   378 ---EDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVG----- 434
               |||:.    ....|.::.:|.:..:.:..|.:...|.:||:|..|   :|:.||:..
 Frog   345 VHMEDTSS----VSTAESQVQIADNDISVNEYETIRSKSPKPQLPPRP---QSKVYSSPANLVQD 402

Human   435 ----------------GSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYRGSS 483
                            ||:...|::.     ..||....| |.:.::||            :.|.
 Frog   403 ANKGKLITAQLPNSGQGSNGSHEKWS-----SKRTVSLIS-PDEAVHSQ------------KSSD 449

Human   484 VSASRVVKPRQSSPQLHNLASYTK-KHHTSSVYSISERLEMKPGPQAQGLVME---AATHSQGDG 544
            ...:|  ..|:||.|..::|.:.: :.|.|.:.|.|:..:..|...:.....|   :.|.|...|
 Frog   450 EVKNR--NNRKSSLQYQDIALWVEDQRHKSKMQSNSKNKQEGPSTYSWSSHAERPQSGTRSVNSG 512

Human   545 S--TDLDSKLTQQLIEFEKSLAGPGTEPDK-ILRHFSIMDFNSEKDIVRGSSKLITEQELPERRK 606
            |  .||||||::||.:|||||:.|....:| :.|||||:|::||.||:||||:|...|:.||:||
 Frog   513 SELIDLDSKLSEQLSQFEKSLSSPTANGNKHVSRHFSILDYSSETDIIRGSSQLSKIQKSPEKRK 577

Human   607 ALRPPPPRPC--------TPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSPKLL 663
            .||||||||.        ..|...|....|.. ...||..::|||||||||...|| |..|||.|
 Frog   578 ILRPPPPRPTLRYNSVSNPSVRGRPQKSADTQ-STYPPFPLKPSRPAPLPPPGNQR-NTPSPKPL 640

Human   664 SRHRPTCETLEKEGPGHMGRSLDQ------TSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEK 722
            .|.....|.|  ..|.:...||::      .||||.:.::|:::||:||:|.:.:|||.|||||:
 Frog   641 PRVSQQSENL--TAPENHDTSLEEQCDKARASPCPFLQLKIDDVERELDVYRKTREELALMLEEE 703

Human   723 QDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQ--SSSLVAPSGSVSAENPEQRMLEKR 785
            |||..|.||||:|:||:||||.|..|||.|::|||||||  .:.....:|| :.||.||||||||
 Frog   704 QDELVRTETLENLEFCDSNIEGLQAELQHLKDMTLLSSQPEGAEQTLSTGS-TTENSEQRMLEKR 767

Human   786 AKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEISDA 850
            :||||||||||:||:||||.|:|.||.|:|..|:.::||:.||||:|.||.:||:.|.||..||:
 Frog   768 SKVIEELLQTEQDYLRDLETCVEHIMGPLQAKQMASVDFDVLFGNIQSVIDISKKFLTALGSSDS 832

Human   851 VGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINL 915
            ||.|||.|..:||..||.|||||:|.|||||.|:||||.||:|.:.:..:|:||.|||.||||||
 Frog   833 VGTVFLDHASDLENVYKEYCQNHEETIALLEAYDKDEKFQKNLLECMETVKNLYQEWGRTNYINL 897

Human   916 GSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKG 980
            ||||||||||:|||||||||||.:||:|||||.||..||.:||:||.||||||||||||||||||
 Frog   898 GSFLIKPVQRIMRYPLLLMELLGATPDSHPDKAPLREAVQSVKDINGNINEYKRRKDLVLKYRKG 962

Human   981 DEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLS 1045
            ||:||::||||||||||||||||||||:|.|||||||||||.|||||||||||||||||||||||
 Frog   963 DENSLIDKISKLNIHSIIKKSNRVSSHIKQLTGFAPQIKDEAFEETEKNFRMQERLIKSFIRDLS 1027

Human  1046 LYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQL 1110
            :||||:||||||||:||:||||:..::|..|||:|.:.|||||::|||:||:|||:|||||||||
 Frog  1028 VYLQHVRESACVKVLAAMSMWDLYSDKGTSDLEKFHKAHRYISEKLFTDFKQRTEKLVISPLNQL 1092

Human  1111 LSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSARNNYEALNAQLLDELPKFHQYA 1175
            |:||.||||||||||||||||:||||||||||||||.|||||||||||||||||||||||||.:|
 Frog  1093 LNMFAGPHKLVQKRFDKLLDFHNCTERAEKLKDKKTQEELQSARNNYEALNAQLLDELPKFHNFA 1157

Human  1176 QGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPE 1240
            :.||.:|:.|||.|||:||..|||:|||||:||.|...||||||:|.||||:|||||||||||||
 Frog  1158 KELFASCMRGYASAHCEFVKLALEELKPLLTLLGVGATEGNLIAVFQEEHSKVLQQLQVFTFFPE 1222

Human  1241 SLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVS 1305
            :||.:|||||||||:||||||.:.....|:.|.:|.|.::||||||||||||:|.:|||||||||
 Frog  1223 NLPPSKKPFERKTIERQSARKTIPSPAKYIPQLDEHRVAVLARYPPEKLFQADRIYNAAQDLDVS 1287

Human  1306 LLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSS 1370
            |.|||||||||::|||||||||||||||||||||.|||||||||:|||||||||.|||||.:|.|
 Frog  1288 LQEGDLVGVIKQQDPMGSQNRWLIDNGVTKGFVYCSFLKPYNPRQSHSDASVGSQSSTESGYGGS 1352

Human  1371 SPRFPRQNSGSTLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSP---- 1431
            ||.|.||||.:||||||.:..|:||:||..|...|::           |.|   |..|.||
 Frog  1353 SPNFSRQNSNNTLTFNPGNSTVAFTAGSIAKHSMDST-----------STS---SGQEDSPVCLP 1403

Human  1432 ----SRCPSDPDSTSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKG 1492
                |:..|:.:....||:.:.      |.:.:..|.|..:.|..|  ..:..|...|:.:..|.
 Frog  1404 DGNLSKKSSETEVPRHPRTSEK------VAKTSTDPESNNHRRQTE--NENSVGDKEQTFESRKA 1460

Human  1493 CARTAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLA 1557
            ..:...:|.....|.|..|.||||||:||||||:|:||||||||||::.||||:|:.||.|||||
 Frog  1461 IRKKTASPAHSDCEQDVCELEGNQVYYAVYTFKSRSPNELSVSANQRVNILEFRDMNGNGEWWLA 1525

Human  1558 EVNGKKGYVPSNYIRKTEYT 1577
            ||.|::||||||||||||||
 Frog  1526 EVEGRRGYVPSNYIRKTEYT 1545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNMBP	NP_056036.1	SH3_DNMBP_N1	6..56	CDD:212728	40/49 (82%)
		SH3_DNMBP_N2	70..123	CDD:212729	33/52 (63%)
		SH3_DNMBP_N3	149..199	CDD:212730	42/49 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		6/39 (15%)
		SH3_DNMBP_N4	247..296	CDD:212731	33/48 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..395		9/62 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	591..624		18/40 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..659		12/19 (63%)
		RhoGEF	785..965	CDD:238091	118/179 (66%)
		BAR_DNMBP	1017..1208	CDD:153273	151/190 (79%)
		SH3_DNMBP_C1	1289..1345	CDD:212732	48/55 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1348..1487		55/146 (38%)
		SH3_DNMBP_C2	1517..1573	CDD:213017	42/55 (76%)
dnmbp	XP_004915928.1	SH3_DNMBP_N1	6..56	CDD:212728	40/49 (82%)
		SH3_DNMBP_N2	70..123	CDD:212729	33/52 (63%)
		SH3_DNMBP_N3	148..198	CDD:212730	42/49 (86%)
		SH3_DNMBP_N4	251..300	CDD:212731	33/48 (69%)
		RhoGEF	767..947	CDD:238091	118/179 (66%)
		BAR_DNMBP	999..1187	CDD:153273	149/187 (80%)
		SH3_DNMBP_C1	1271..1327	CDD:212732	48/55 (87%)
		SH3_DNMBP_C2	1485..1541	CDD:213017	42/55 (76%)