Protein Alignment PPIP5K2 and l(1)G0196

DIOPT Version :10

• Sequence 1: NP_001268400.1
• Gene: PPIP5K2 / 23262
• HGNCID: 29035
• Length: 1278
• Species: Homo sapiens
• Sequence 2: NP_001097041.2
• Gene: l(1)G0196 / 33137
• FlyBaseID: FBgn0027279
• Length: 1846
• Species: Drosophila melanogaster
• Alignment Length: 1371
• Identity: 725/1371 - (52%)
• Similarity: 896/1371 - (65%)
• Gaps: 170/1371 - (12%)

Human     7 FFVGPEDTEINPGNYRHFFHHADE--DDEEEDDSPPERQIVVGICSMAKKSKSKPMKEILERISL 69
            |::|.:|     ||....|..:::  |.:....|...:|:|||||:||||::||||||||.|:..
  Fly    33 FYLGLQD-----GNGDTDFGDSNDGMDSDTSTSSSNSKQVVVGICAMAKKTQSKPMKEILTRLGE 92

Human    70 FKYITVVVFEEEVILNEPVENWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDR 134
            |::|.:|.|||.|||.|||:|||.||||:|||||||||:||:.||:||||||:|:|:|||.||||
  Fly    93 FEFIKLVTFEENVILREPVQNWPTCDCLVSFHSKGFPLEKAIEYAQLRNPFVLNNLHMQYDIQDR 157

Human   135 REVYSILQAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIY 199
            |.||:||:.|||.:||||:|:||..:||...|||.||||||||..|.||||||||||||||:|||
  Fly   158 RRVYAILEKEGIEIPRYAVLDRDSPDPKHHELIESEDHVEVNGITFNKPFVEKPVSAEDHNIYIY 222

Human   200 YPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKS 264
            |||||||||||||||||||||||||||.||||||:|||:||||||||||||||||||||||||||
  Fly   223 YPTSAGGGSQRLFRKIGSRSSVYSPESRVRKTGSFIYEDFMPTDGTDVKVYTVGPDYAHAEARKS 287

Human   265 PALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVK 329
            |||||||||||||||:|||||||..||||:.||||||||||||||||||||:|||||||||||||
  Fly   288 PALDGKVERDSEGKEIRYPVILNHSEKLISRKVCLAFKQTVCGFDLLRANGKSYVCDVNGFSFVK 352

Human   330 NSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTP 394
            ||.||||||||||||:::|||.|..|||||:|.:.:|.||||||.|.|||||||:||||||||||
  Fly   353 NSNKYYDDCAKILGNMILRELTPTLHIPWSVPFQLDDPPIVPTTFGKMMELRCVVAVIRHGDRTP 417

Human   395 KQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDSEIEENKPKL 459
            |||||:||||.|||::|||.||||.|.:|||:||||||:|||||.||.|:.....:||||.:.||
  Fly   418 KQKMKVEVRHPKFFEIFEKYDGYKLGHVKLKRPKQLQEILDIARFLLSEIHTKAHAEIEEKESKL 482

Human   460 EQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDS----RREEPSLLLVLKWGGELTPAGR 520
            ||||.||||||||||||||||:.|.|.|.|:.||.::.:    :..||||:|:||||||||||||
  Fly   483 EQLKNVLEMYGHFSGINRKVQMKYQPKGRPRGSSSDDTNLAADQPVEPSLVLILKWGGELTPAGR 547

Human   521 VQAEELGRAFRCMYPGGQG--DYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLA 583
            :|||||||.||||||||||  ||:|..|.||||||||:|||||||||||||||||||||||||||
  Fly   548 IQAEELGRIFRCMYPGGQGRSDYSGTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLA 612

Human   584 LEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSIS 648
            |||||||||||||||||.|||||:|.|| |..|...|.||||::|.||:|:.||.|.:.|..|.|
  Fly   613 LEGELTPILVQMVKSANTNGLLDNDCDS-SKYQNLAKGRLHELMQNDREFSKEDRELINPCNSKS 676

Human   649 LIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKT 713
            :.:::..:||||..|..|:.||:.|...|..:.:|||:.|..|||.||.:||..||.|:||||.|
  Fly   677 ITQALDFVKNPVDCCHHVHLLIRELLHIISIKKDDPKTKDAILYHGETWDLMRCRWEKIEKDFST 741

Human   714 KNGRYDISKIPDIYDCIKYDVQHN-GSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKG 777
            |:..:|||||||||||||||:||| .:|:.:...|||..:|.|||||||||||:|..|||.|.:|
  Fly   742 KSKLFDISKIPDIYDCIKYDLQHNQHTLQYDQAEELYIYAKNLADIVIPQEYGLTPQEKLAIGQG 806

Human   778 YCTPLVRKIRSDLQRTQD---DDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYG 839
            .|:||:|||:.||||..|   |:.:|:|:|.||.||.||:|||||||||||||||||||::||||
  Fly   807 ICSPLLRKIKGDLQRNIDEVEDEFMNRLNPHYSHGVASPQRHVRTRLYFTSESHVHSLLTVLRYG 871

Human   840 ALCNTNDSQNEDGGMVKEMESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHV 904
            .|.|.               ..||||:|||||:::|:|||||:||||||||||.||.:|||||||
  Fly   872 GLLNV---------------VTDEQWRRAMDYISMVSELNYMSQIVIMLYEDPTKDPTSEERFHV 921

Human   905 ELHFSPGAKGCEEDKNLPSGYGYRPAS----------RENEGRRPFKIDNDDEPH---------- 949
            |||||||...|.: ||||.|.|:||.|          :.::...|.:|:.:::.:
  Fly   922 ELHFSPGVNCCVQ-KNLPPGPGFRPHSHGDNACNVSLQSSDESNPARIEEENDSNSGEEREGKKR 985

Human   950 -TSKRDEVDRAV-------------ILFKPMVSEPIHI--------HRKSPLPR-------SRKT 985
             ||.:...||:.             :..|...|:||.|        |....|.:       |.:.
  Fly   986 GTSGQRSTDRSAERISPAFGFNRLELRSKQFKSKPIPIGAHHTVSGHEAMDLAKRLNEELASHQQ 1050

Human   986 ATNDEESPLS----VSSPEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQ 1046
            ..|.:..|:|    ..:|:              ...|.||.||..:|.|..|. ..:|..||
  Fly  1051 QQNQQLRPISPDIRAVTPD--------------CEPRSRSFEQRPTSGVCAKE-PVSSPDFG--- 1097

Human  1047 QVVSENANYLRTPRTLVEQKQNPTVGSHC---AGLFSTSVLGGSSSAPNLQDYARTHRKKLTSSG 1108
                :|:      ||     ::...|..|   .|..|.|..|||...   .|:....:.::|:|.
  Fly  1098 ----DNS------RT-----RSSEFGETCHARVGTASNSDGGGSHPR---ADHRTAFQIRVTNSL 1144

Human  1109 C---IDDATRGSAVKRFSISFARHP--------TNEHLHLYRCWSVSSVEFLGSSGFELYSM--V 1160
            .   ||.:|  :.:....|.|:.||        :::..|:.....:.|.:    .|.||..:  :
  Fly  1145 SFFKIDSST--NELPLSDIDFSLHPPTPQCGPLSHKRFHILTMRRMESCD----DGAELEQVRHL 1203

Human  1161 PSICPLETLHNALSLKQVDEFLASIASPSSDV-----------PRKTAEISSTALRSSPIMRKKV 1214
            |.|.|:.|....||........|...|.|..:           |::|...|...  ..|.....|
  Fly  1204 PQISPMATNERPLSSCNCSSSAAQAHSHSKSLMDLAQAVVMTSPQETGPNSEQG--CDPTTAADV 1266

Human  1215 SLNTY-TPAKILPTPPATLKSTKASSKP----------ATSGPSSAVVPNTSSRKKNITSKTETH 1268
            |:::: ...::..:.||.|.|....::|          .|:.||::.:.....:.|.:.|.|.:
  Fly  1267 SVSSFDDDFQLSSSAPAILMSAHFGNRPVVASLSSMVHVTTSPSASTLQLCRDKDKALASGTSS- 1330

Human  1269 EHKKNT 1274
            .|.|.|
  Fly  1331 AHSKAT 1336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPIP5K2	NP_001268400.1	PPIP5K2_N	44..133	CDD:465643	62/88 (70%)
		LysX	<111..326	CDD:439959	179/214 (84%)
		His_Phos_2	379..909	CDD:395259	352/539 (65%)
l(1)G0196	NP_001097041.2	PPIP5K2_N	67..156	CDD:465643	62/88 (70%)
		LysX	<135..373	CDD:439959	199/237 (84%)
		His_Phos_2	402..926	CDD:395259	352/539 (65%)