Protein Alignment DDHD2 and PAPLA1

DIOPT Version :10

• Sequence 1: NP_056029.2
• Gene: DDHD2 / 23259
• HGNCID: 29106
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_609185.1
• Gene: PAPLA1 / 34109
• FlyBaseID: FBgn0031990
• Length: 2016
• Species: Drosophila melanogaster
• Alignment Length: 774
• Identity: 294/774 - (37%)
• Similarity: 418/774 - (54%)
• Gaps: 152/774 - (19%)

Human     7 QQEQLSQSDPS----PSPNSCSSF----------------ELIDMDAGSL--------------- 36
            |.::.||:..|    |..::||.|                :|:....|.|
  Fly  1295 QLQERSQTPVSNLVEPPSSACSEFSTLAPAPTQTDRQSGDDLLQQHLGELPEDILRELRMASASS 1359

Human    37 -------------YEPVSPHWFYCKIIDSKETWIPFNSEDSQQLEEAYSSGKGCNGRVVPTDGGR 88
                         |.||..||||.:.:|:|..|.||:..||..||.:.:...  :..::|.:|||
  Fly  1360 EKGQVATPPVAIPYSPVVAHWFYKRSVDTKFIWTPFSHYDSALLETSLNLDD--STLIIPVEGGR 1422

Human    89 YDVHLGERMRYAVYWDELASEVRRCTWFYKGDKDNKYVPYSESFSQVLEETYMLAVTLDEWKKKL 153
            |||::.||.:..|||:..|.|||||:||||| .|:|||||:|..:.:||..|..:....||.:|:
  Fly  1423 YDVNIKERTKTPVYWEGKAIEVRRCSWFYKG-VDSKYVPYTEDTAALLEAEYKRSAETGEWHQKI 1486

Human   154 ESPNREIIILHNPKLMVHYQPVAGSDDWGSTPTEQGRPRTVKRGVENISVDIHCGEPLQIDHLVF 218
            ...|.|.::.|.|.::||:.|...:|.||::.....|||.|||.:::.:::  .||..::|||:|
  Fly  1487 MLANGEQVVFHGPTVIVHFLPQQNADTWGASTQGSMRPRVVKRDLDDFTIE--QGESQRVDHLLF 1549

Human   219 VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPLHS--TGV 281
            :|||||.||||:.||:.:.|:|||.::..|:|:|:|.:.:...:||||.||::||..|||  .|:
  Fly  1550 MVHGIGSACDLKMRSVEEVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGI 1614

Human   282 DVDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVS 346
            |..|:.|||.||.|||:|||||:|||.||.||.|||.|::|||..:|.:|..:..|:|:|.||||
  Fly  1615 DEKLKSITLESIPRLRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVS 1679

Human   347 IAGHSLGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKV 411
            :||||||||||||:|.:|                           |.||:.:        |:.|.
  Fly  1680 LAGHSLGSLILFDLLCHQ---------------------------EPLKESE--------EENKE 1709

Human   412 DKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR 476
            :.:.|                |:|:     |::|..:....|.|:..|.|..|:
  Fly  1710 NPDQL----------------PQKQ-----SSQKVQLPTSDPLPKQVSYAMGPE----------- 1742

Human   477 NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFD 541
                   |.||..:.|.:||:.|:.|||.|||||||:|:||:.::..::..|||.||:||:||||
  Fly  1743 -------GTGQPVITYTQLIFHPKKFFALGSPIGMFVTIRGIDKLGLDFHLPTCPGFYNIFHPFD 1800

Human   542 PVAYRIEPMVVPGVE-FEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAP 605
            |||||||.:|.|.:. ..|:|||||||||||||||:|.:||:..|:|...:.:.:....|.....
  Fly  1801 PVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLT 1865

Human   606 YPALQASETPEETEAEPESTSEKPSDVNTE---ETSVAVKE-----------------EVLPIN- 649
            .......|..|..|.|...||.:.....||   |:|||...                 |.:.::
  Fly  1866 TVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDF 1930

Human   650 -VGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLD 707
             :|.||..:|:||||||.|:|..|||:|||.||:|||.||||:|.|:||||.:.||..|
  Fly  1931 PLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIYASLGISTD 1989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDHD2	NP_056029.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		5/20 (25%)
		WWE	43..112	CDD:460715	28/68 (41%)
		SAM_DDHD2	379..447	CDD:188984	10/67 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..470		5/20 (25%)
		DDHD	495..699	CDD:460725	102/226 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..638		9/31 (29%)
PAPLA1	NP_609185.1	PHA03247	<38..590	CDD:223021
		PHA03247	<375..1012	CDD:223021
		Atrophin-1	888..>1179	CDD:460830
		WWE	1379..1446	CDD:460715	28/68 (41%)
		DDHD	1754..1981	CDD:460725	102/226 (45%)