Protein Alignment PACS2 and KrT95D

DIOPT Version :10

• Sequence 1: XP_006720153.1
• Gene: PACS2 / 23241
• HGNCID: 23794
• Length: 905
• Species: Homo sapiens
• Sequence 2: NP_524473.2
• Gene: KrT95D / 42843
• FlyBaseID: FBgn0020647
• Length: 1175
• Species: Drosophila melanogaster
• Alignment Length: 1151
• Identity: 354/1151 - (30%)
• Similarity: 509/1151 - (44%)
• Gaps: 296/1151 - (25%)

Human     5 GRLGLPGAPGAL--NTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVK 67
            |..||....|..  ..||||.|||.||||.:.|:|:|||||||:.:|.:...|..:..|:.:|||
  Fly    55 GTAGLSAGAGMTTGQKPVPMKLFAAWEVDRTPPNCIPRLCSLTITRLSILTPLPGDTTSLSLAVK 119

Human    68 MQGSKRILRSHEIVL---------------PPS-------------GQV-------------ETD 91
            ||.|||.||||||.:               |.|             |.|             ||:
  Fly   120 MQSSKRTLRSHEIPINGLALTSSASLQGNSPMSVAGGVGGGGVGTPGSVGTGGGLGVAVPLTETE 184

Human    92 LALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLC 156
            |.|.||||||||:||:||:|.|:|||||:||:||||||||||.|.|.|..|:|...:  .::.|.
  Fly   185 LDLHFSLQYPHFIKRDGNRLVILLQRRKKYKSRTILGYKTLAEGIIRMDAVLQKSMD--MIIELT 247

Human   157 SSIKE-------APVKAAEIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASD 214
            :|.|.       |.::|..:     ||.|:||::....:...|.....||:|:.|:..|..|.:|
  Fly   248 ASGKNGRPGTVVACLRAERV-----SSIPVDHDNKNNNSVLLADRVAEYSDEDEEAEFSSGEFND 307

Human   215 DA-----VQGQD------------------------------------------------LDED- 225
            :|     ::|.|                                                :|.|
  Fly   308 EANELGLIRGYDPKDPRDYNHPAKHDMRKYRNKLQRSGIEDCALVGHHPGSIQHHHPGVVVDSDS 372

Human   226 DFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSDEVLDSEQDPAEHIPEAEEDLDLLY 290
            :|::......|....||.|: :|:|||||:||||:|||||:|:..............|.|||.|:
  Fly   373 EFEMKDKSSSRAKFSRTISL-QQRNFKQKIVALLKRFKVSEELEGESGHRGTAALRGERDLDALF 436

Human   291 ---DTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYF----------------------------- 323
               ::|......|||||| |..||.|||||.|||:|
  Fly   437 QELESLSCCEGDDSGPDM-DSISVGSTPKPSLRPFFTNSRIMLHDNITGNGGDLSQLVGGGLGPG 500

Human   324 -------EGLSHSSSQTEIGSIHSARSHKEPP--------SPADVPEKTRSLGGRQPSDSVSDTV 373
                   |..|...|.....|.::..::|...        :.|..|::    ||...|.:..:..
  Fly   501 TGTAGNSERRSSDKSDQLTNSSYNLENNKNQKCIHLTNNNNSATTPDR----GGNDSSGNEGNAG 561

Human   374 ALQGVPGPREHPGQPEDSPEAEASTL---DVFTERLPP---------SGRI-----TKTESLVIP 421
            ...|      ....|::||..:...|   .:..::|.|         ||.:     |:..|.:..
  Fly   562 YTDG------QNSDPQNSPPRDKDYLRLQQMQQQQLTPVSSVAASMGSGSVITPAQTEKRSRLFR 620

Human   422 STRSEGKQAGRRGRSTSLKERQAARPQNERANSLDNERCPDARSQLQVQLQ----IPRKTVYDQL 482
            ::.:....||..|.|.|   ..:|....:|.::|.....|  ||.|:..|.    .|||.:.|||
  Fly   621 TSSNTPANAGSGGNSVS---AISASGGGKRKHTLSLSAEP--RSVLEACLSPTNVEPRKLLLDQL 680

Human   483 NHILISDDQ-LPENIILVNTSDWQG-----QFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQ 541
            :.:...:|. :||.:.:::..:..|     ..|..:......|.....:.|:|:|....::::||
  Fly   681 SRVFAGEDSAIPEVVTIISPPEALGGSALLAKLVTLFANSFKPAFVPQNTAEVKAVLQALMAKIQ 745

Human   542 RYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSH--PVARYLG 604
            :|||.|::||..||:.:.|......|.||.:||.:..:.||||.::||.::|:|..  .|||:|.
  Fly   746 KYCNSNAKPPHTVKVLLIGGDWLQGATLRHYVELMGVRPPDWLNHLRFYLVPVGGSCGSVARHLS 810

Human   605 SVDYRYNNFFQDLAWRDLFNKLEAQSAV------------------------QDTPDIVSRITQY 645
            .:|..|...|....|..|..:..|.:|.                        .|..::|.||.:|
  Fly   811 QMDQAYAVMFGSDNWTQLCERAAATAAAVSAVTTVNATALTTNLADAAGVAKSDIAELVQRIQRY 875

Human   646 IAGANCAHQLPIAEAMLTYKQKRKKHFHFDFTLSPDEESSQKFIPFVGVVKVGIVEP-------- 702
            :..|....|:||||||:.||               ||:|.|.|:|||..|::|.::.
  Fly   876 LLAAGPCTQIPIAEAMVNYK---------------DEDSCQIFVPFVSDVRIGYLDAQASLDLEE 925

Human   703 ---------SSATSGD-SDDAAPSGS-------GTLSSTPPSASPAAKEASP--TPPSSPS---- 744
                     |...||. |..|.|.||       |.:|.:||......:.:.|  |||||.|
  Fly   926 NAAGSNAVGSGLGSGSASSSAIPIGSQSSPNVHGVVSGSPPQQQSLGRISPPLQTPPSSASSHRE 990

Human   745 --VSGGLSSPSQG---------VGAELMGLQVDYWTAAQPADRKRDAEKKDLPV-----TKNTLK 793
              .|..||:||..         ..||.:.||||||...:|.:......|..|..     .||::|
  Fly   991 RNTSESLSTPSSVQQQSFSGALAAAEAVELQVDYWPLVRPGEGHAKESKGGLSKGSDAGGKNSIK 1055

Human   794 CTFRSLQVSRLPSSGEAAATPTMSMTV--VTKE-KNKKVMFL-PKKAKDKDVESKSQCIEGISRL 854
            .|||:|||.|||...:........:||  .||| |.|::|.| .||.|::|:| |.||:||::||
  Fly  1056 STFRNLQVWRLPQHAQQLGDMFNGLTVSFATKEKKQKQIMRLGKKKDKERDLE-KEQCVEGVARL 1119

Human   855 ICTARQQQNM-LRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFG 899
            ||:.:|...: |||.|||.|.:.|||||:::||.:|||:|||.:.|
  Fly  1120 ICSPKQSHPVPLRVYIDGTEWTGVKFFQVSSQWQTHVKNFPIALIG 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PACS2	XP_006720153.1	Pacs-1	478..901	CDD:463027	164/506 (32%)
KrT95D	NP_524473.2	Pacs-1	676..1167	CDD:463027	164/506 (32%)